Noncationic Dipeptide Mimic Oligomers As Cell Penetrating Nonpeptides (CPNP)

Lubomir L. Vezenkov; Marie Maynadier; Jean-Francois Hernandez; Marie-Christine Averlant-Petit; Olivier Fabre; Ettore Benedetti; Marcel Garcia; Jean Martinez; Muriel Amblard

doi:10.1021/bc1002086

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Noncationic Dipeptide Mimic Oligomers As Cell Penetrating Nonpeptides (CPNP)

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Noncationic Dipeptide Mimic Oligomers As Cell Penetrating Nonpeptides (CPNP)

Lubomir L. Vezenkov, Marie Maynadier, Jean-Francois Hernandez, Marie-Christine Averlant-Petit, Olivier Fabre, Ettore Benedetti, Marcel Garcia, Jean Martinez et Muriel Amblard

Bioconjugate chemistry, Vol.21(10), pp.1850-1854

20/10/2010

DOI: https://doi.org/10.1021/bc1002086

PMID: 20815388

Résumé

Biochemical Research Methods

Biochemistry & Molecular Biology

Chemistry

Chemistry, Multidisciplinary

Chemistry, Organic

Life Sciences & Biomedicine

Physical Sciences

Science & Technology

Small oligomers of constrained dipeptide mimics have been synthesized as new vectors for intracellular delivery. They are highly internalized by cells and delivered to the lysosomes by an energy-dependent pathway. This new class of vectors referred to as cell penetrating nonpeptides (CPNP) possess the distinctive feature of being noncationic.

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Titre: Noncationic Dipeptide Mimic Oligomers As Cell Penetrating Nonpeptides (CPNP)
Créateurs - sans rôle: Lubomir L. Vezenkov - Univ Montpellier 1, CNRS, Inst Biomol Max Mousseron, UMR5247, F-34000 Montpellier, France
Marie Maynadier - Inserm
Jean-Francois Hernandez - Institut des Biomolécules Max Mousseron
Marie-Christine Averlant-Petit - LCPM, UMR7568, F-54001 Nancy, France
Olivier Fabre - LCPM, UMR7568, F-54001 Nancy, France
Ettore Benedetti - Univ Naples Federico 2, Ist Biostrutture & Bioimmagini CNR, I-80134 Naples, Italy
Marcel Garcia - Inserm
Jean Martinez - Univ Montpellier 1, CNRS, Inst Biomol Max Mousseron, UMR5247, F-34000 Montpellier, France
Muriel Amblard - Institut des Biomolécules Max Mousseron
Détails de publication: Bioconjugate chemistry, Vol.21(10), pp.1850-1854
Éditeur: Amer Chemical Soc
Nombre de pages: 5
Note de subvention: 3953 / ARC; Australian Research Council ANR-08-BLAN-0066-01 / Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR)
Identifiants: 99138627209311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article