Non-Hodgkin lymphoma risk in adults living with HIV across five continents The AIDS-defining Cancer Project Working Group of leDEA and COHERE in EuroCoord

Eliane Rohner; Lukas Butikofer; Kurt Schmidlin; Mazvita Sengayi; Mhairi Maskew; Janet Giddy; Richard D. Moore; James J. Goedert; M. John Gill; Michael J. Silverberg; Pragna Patel; Jessica Castilho; Jennifer Hoy; Annette Sohn; Firouze Bani-Sadr; Ninon Taylor; Vassilios Paparizos; Vincent Le Moing; Fabrice Bonnet; Annelies Verbon; Jorg Janne Vehreschild; Frank A. Post; Caroline Sabin; Amanda Mocroft; Fernando Dronda; Niels Obel; Sophie Grabar; Vincenzo Spagnuolo; Andrea Antinori; Eugenia Quiros-Rol-dan; Cristina Mussini; Jose M. Miro; Laurence Meyer; Barbara Hasse; Deborah Konopnicki; Bernardino Roca; Francois Boue; Diana Barger; Dorthe Raben; Gary M. Clifford; Silvia Franceschi; Norbert Brockmeyer; Matthias Egger; Julia Bohlius; AIDS-Defining Cancer Project Work

doi:10.1097/QAD.0000000000002003

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Non-Hodgkin lymphoma risk in adults living with HIV across five continents The AIDS-defining Cancer Project Working Group of leDEA and COHERE in EuroCoord

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Non-Hodgkin lymphoma risk in adults living with HIV across five continents The AIDS-defining Cancer Project Working Group of leDEA and COHERE in EuroCoord

Eliane Rohner, Lukas Butikofer, Kurt Schmidlin, Mazvita Sengayi, Mhairi Maskew, Janet Giddy, Richard D. Moore, James J. Goedert, M. John Gill, Michael J. Silverberg, …

AIDS (London), Vol.32(18), pp.2777-2786

28/11/2018

DOI: https://doi.org/10.1097/QAD.0000000000002003

Résumé

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Virology

Objective: To compare non-I lodgkin lymphoma (NHL) incidence rates in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods: We included cohort data of adults living with HIV who started ART after 1995 within the framework of the International epidemiology Databases to Evaluate AIDS (leDEA) and (he Collaboration of Observational HIV Epidemiological Research in Europe (COHERE). We used flexible parametric survival models to compare regional NHL rates at 2 years after ART start and to identify risk factors for NHL. Results: We included 210898 adults with 1.1 million person-years (pys) of follow-up and 1552 incident NHL cases (raw overall incidence rate 142/100000 pys). After adjusting for age at ART start, first-line ART regimen, calendar period of ART start, and especially current CD4(+) cell count, NHL rates were similar across regions for most population groups. However, South African women remained at increased risk of developing NHL compared with their European counterparts [adjusted hazard ratio [aHR] 1.79, 95% CI 1.19-2.701. In Europe, Latin, and North America, NHL risk was highest in MSM (aHR 1.30, 95% CI 1.14-1.48), followed by heterosexual men (referent), and women (aHR 0.66, 95% CI 0.57-0.78). Conclusion: The risk of developing NHL is higher in women in South Africa than in Europe and higher in MSM compared with heterosexual men and women. Reasons for these differences remain unclear. Early ART access and regular patient monitoring to avert low CD4(+) cell counts remain key for NHL prevention. copyright (C) 2018 WolLers Kluwer Health, Inc. All rights reserved.

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Titre: Non-Hodgkin lymphoma risk in adults living with HIV across five continents The AIDS-defining Cancer Project Working Group of leDEA and COHERE in EuroCoord
Créateurs - sans rôle: Eliane Rohner - Univ Bern, Inst Social & Prevent Med, Mittelstr 43, CH-3012 Bern, Switzerland
Lukas Butikofer - Univ Bern, Inst Social & Prevent Med, Mittelstr 43, CH-3012 Bern, Switzerland
Kurt Schmidlin
Mazvita Sengayi - Natl Hlth Lab Serv, Natl Canc Registry, Johannesburg, South Africa
Mhairi Maskew - Univ Witwatersrand, Fac Hlth Sci, Hlth Econ & Epidemiol Res Off, Dept Internal Med,Sch Clin Med, Johannesburg, South Africa
Janet Giddy - McCord Hosp, Dept Med, Durban, South Africa
Richard D. Moore - Johns Hopkins Univ, Sch Med, Baltimore, MD USA
James J. Goedert - NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
M. John Gill - Univ Calgary, Calgary, AB, Canada
Michael J. Silverberg - Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA
Pragna Patel - Ctr Dis Control & Prevent, Div HIV AIDS Prevent, Atlanta, GA USA
Jessica Castilho - Vanderbilt Univ, Med Ctr, Nashville, TN USA
Jennifer Hoy - Alfred Hosp, Dept Infect Dis, Melbourne, Vic, Australia
Annette Sohn - TREAT Asia amfAR Fdn AIDS Res, Bangkok, Thailand
Firouze Bani-Sadr - Reims Champagne Ardenne Univ, Fac Med, CHU Reims, Hop Robert Debre,Trop & Infect Dis, Reims, France
Ninon Taylor - Paraceisus Med Univ, Med Dept Haematol Med Oncol Haemostaseol Infect D, Oncol Ctr, Salzburg, Austria
Vassilios Paparizos - Syngros Hosp, AIDS Unit, Clin Venereol & Dermatol Dis, Athens Med Sch, Athens, Greece
Vincent Le Moing - Montpellier Univ, Montpellier, France
Fabrice Bonnet - Hop St Andre, CHU Bordeaux, Serv Med Interne & Malad Infect, Bordeaux, France
Annelies Verbon - Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
Jorg Janne Vehreschild - Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany
Frank A. Post - Kings Coll Hosp NHS Fdn Trust, London, England
Caroline Sabin - UCL, Inst Global Hlth, London, England
Amanda Mocroft - UCL, Inst Global Hlth, London, England
Fernando Dronda - Hosp Ramon & Cajal, Dept Infect Dis, Madrid, Spain
Niels Obel - Copenhagen Univ Hosp, Dept Infect Dis, Copenhagen, Denmark
Sophie Grabar - Sorbonne Univ, INSERM, UMR S 1136, IPLESP, Paris, France
Vincenzo Spagnuolo - Ist Sci San Raffaele, Dept Infect Dis, Milan, Italy
Andrea Antinori - INMI L Spallanzani, Rome, Italy
Eugenia Quiros-Rol-dan - Univ Brescia, Infect & Trop Dis Inst, Brescia, Italy
Cristina Mussini - Univ Hosp, Infect Dis Clin, Modena, Italy
Jose M. Miro - Univ Barcelona, Infect Dis Serv, Hosp Clin IDIBAPS, Barcelona, Spain
Laurence Meyer - Univ Paris Sud, INSERM, U1018, Epidemiol HIV,Reprod,Paediat,CESP, Paris, France
Barbara Hasse - Univ Zurich, Univ Hosp Zurich, Divis Infect Dis & Hosp Epidemiol, Zurich, Switzerland
Deborah Konopnicki - Univ Libre Bruxelles, Dept Infect Dis, St Pierre Univ Hosp, Brussels, Belgium
Bernardino Roca - Hosp Gen Univ, Castellon de La Plana, Spain
Francois Boue - Univ Paris Sud, Paris, France
Diana Barger - Univ Bordeaux, ISPED, INSERM, Bordeaux Populat Hlth Res Ctr,Team Morph3eus,UMR, F-33000 Bordeaux, France
Dorthe Raben - Rigshosp, Dept Infect Dis, CHIP, Copenhagen, Denmark
Gary M. Clifford - Int Agcy Res Canc, Lyon, France
Silvia Franceschi - Ctr Riferimento Oncol Aviano CRO IRCCS, Aviano, Italy
Norbert Brockmeyer - Ruhr University Bochum
Matthias Egger - Univ Bern, Inst Social & Prevent Med, Mittelstr 43, CH-3012 Bern, Switzerland
Julia Bohlius - Univ Bern, Inst Social & Prevent Med, Mittelstr 43, CH-3012 Bern, Switzerland
AIDS-Defining Cancer Project Work
Détails de publication: AIDS (London), Vol.32(18), pp.2777-2786
Éditeur: Lippincott Williams & Wilkins
Nombre de pages: 10
Note de subvention: Bristol-Myers Squibb PZ00P3_136620 / Swiss National Science Foundation (SNF); Swiss National Science Foundation (SNSF) Janssen-Cilag; Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc F31AI124794; F31DA037788; G12MD007583; K01A I093197; K01AI131895; K23EY013707; K24AI065298; K24AI118591; K24DA000432; KL2TR000421; M01R R000052; N01CP01004; N02CP055504; 91027; P30AI027757; P30AI027763; P30AI027767; P30AI036219; P30AI050410; P30AI094189; P30AI 110527 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ViiV Healthcare MR/M004236/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) National Cancer Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Ontario Ministry of Health and Long Term Care; Ontario Ministere de la Sante et des Soins de longue duree (MSSLD) 260694 / European Union Seventh Framework Programme (FP7/2007-2013) under EuroCoord grant
Identifiants: 99148894109311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article