Résumé
The synthesis of new but unstable α-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups in order to avoid decomposition in diamagnetic nitrones. Relaxivity studies of (
R,S)-4-(hydroxymethyl)-2,2,4-trimethyloxazolidin-3-oxyl
1 show no beneficial effect due to the presence of an hydroxymethyl group in the vicinity of the N-O group on the paramagnetic properties of nitroxides.
The synthesis of new α-(hydroxymethyl)oxazolidin-3-oxyls was achieved after protection by silylation of the hydroxyl groups. Relaxivity studies of (
R,S)-4-(hydroxymethyl)-2,2,4-trimethyloxazolidin-3-oxyl show no beneficial effect of the presence of an hydroxymethyl in α of the N-O group.