Résumé
The (2
S,4
R)- and (2
S,4
S)-4-hydroxyglutamates activate cloned mGlu
1a, mGlu
2, and mGlu
8a receptors with different potencies. Best results were obtained with the (2
S,4
S) isomer being almost as potent as glutamate on mGlu
1aR and mGlu
8aR. Data are interpreted on the basis of the binding site model and X-ray structure.
The (2
S,4
R)- and (2
S,4
S)-4-hydroxyglutamates are agonists of mGlu
1aR, mGlu
2R, and mGlu
8aR. Activities are discussed on the basis of binding site models.