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New 1,3-amino alcohols derived from enantiopure bridgehead β-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acids
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New 1,3-amino alcohols derived from enantiopure bridgehead β-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acids

Christophe Andre, Monique Calmes, Francoise Escale, Muriel Amblard, Jean Martinez et Olivier Songis
Amino acids, Vol.43(1), pp.415-421
01/07/2012
PMID: 21968501

Résumé

Biochemistry & Molecular Biology Life Sciences & Biomedicine Science & Technology
Constrained enantiopure bicyclic beta-amino acids derived from the asymmetric Diels-Alder reaction of the (R)-benzyl-4-(3-acryloyloxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)-benzoate and the 1-(benzyloxycarbonylamino)cyclohexadiene provide original templates for the construction of new rigid enantiopure 1,3-amino alcohols.

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