Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

Anna Turkova; Ellen White; Adeodata R Kekitiinwa; Vivian Mumbiro; Elizabeth Kaudha; Afaaf Liberty; Grace Miriam Ahimbisibwe; Tumelo Moloantoa; Ussanee Srirompotong; Nozibusiso Rejoice Mosia; Thanyawee Puthanakit; Robin Kobbe; Clàudia Fortuny; Hajira Kataike; Dickson Bbuye; Sathaporn Na-Rajsima; Alexandra Coelho; Abbas Lugemwa; Mutsa F Bwakura-Dangarembizi; Nigel Klein; Hilda A Mujuru; Cissy Kityo; Mark F Cotton; Rashida A Ferrand; Carlo Giaquinto; Pablo Rojo; Avy Violari; Diana M Gibb; Deborah Ford; Amina Farhana Mehar; Pattamukkil Abraham; Elaine Abrams; Judith Acero; Gerald Muzorah Agaba; Grace Ahimbisibwe; Barbara Ainebyoona; Winnie Akobye; Yasmeen Akhalwaya; Nazim Akoojee; Shabinah S Ali; Pauline Amuge; Catherine Andrea; Maria Angeles Muñoz Fernandez; Rogers Ankunda; Diana Antonia Rutebarika; Suvaporn Anugulruengkitt; Tsitsi Apollo; Moherndran Archary; Ronelle Arendze; Juliet Ategeka; Eunice Atim; Lorna Atwine; Abdel Babiker; Sarah Babirye; Enock Babu; Edward Bagirigomwa; Angella Baita; David Balamusani; Patsy Baliram; David Baliruno; Colin Ball; Henry Balwa; Alasdair Bamford; Srini Bandi; Dominique Barker; Linda Barlow-Mosha; Shazia Begum; Osee Behuhuma; Sarah Bernays; Rogers Besigye; Maria Bester; Joyline Bhiri; Davide Bilardi; Kristien Bird; Pauline Bollen; Chiara Borg; Anne-Marie Borges Da Silva; Jackie Brown; Elena Bruno; Torsak Bunupuradah; David Burger; Nomzamo Buthelezi; Mutsa Bwakura-Dangarembizi; Africanus Byaruhanga; Joanna Calvert; Petronelle Casey; Haseena Cassim; Sphiwee Cebekhulu; Sanuphong Chailert; Suwalai Chalermpantmetagul; Wanna Chamjamrat; Man Chan; Precious Chandiwana; Thannapat Chankun; Sararut Chanthaburanun; Nuttawut Chanto; Ennie Chidziva; Minenhle Chikowore; Joy Chimanzi; Dujrudee Chinwong; Stuart Chitongo; Moses Chitsamatanga; Joshua Choga; Duangrat Chutima; Polly Clayden; Angela Colbers; Alexandra Compagnucci; Ana Constança Mendes; Magda Conway; Jane Crawley; Tim R Cressey; Jacky Crisp; Ana Cristina Matos; Sumaya Dadan; Jacqui Daglish; Siva Danaviah; Tseleng Daniel; Anita De Rossi; Sukanda Denjanta; Els Dobbels; Maria Dowie; Prosper Dube; Benedictor Dube; Nimisha Dudakia; Alice Elwana; Cristina Epalza; David Eram; Juan Erasmus; Peter Erim; Luis Escosa Garcia; Zaakirah Essack; Carolina Estepa; Monica Etima; Alexandre Fernandes; Maite Fernandez; Felicity Fitzgerald; Jacquie Flynn; Claudia Fortuny Guasch; Caroline Foster; George Fourie; Yolandie Fourie; Sophie Foxall; Derusha Frank; Kate Gandhi; India Garcia; Kathleen Gartner; Joshua Gasa; Gugu Gasa; Coral Gomez Rico; Daniel Gomez-Pena; Secrecy Gondo; Anna Goodman; Maria Gorreti Nakalema; Winnie Gozhora; Pisut Greetanukroh; Biobanco Gregorio Maranon; Tiziana Grossele; Shamiso Gwande; Tapiwa Gwaze; Tsitsi Gwenzi; James Hakim; Emmanuel Hakiza; Abdul Hamid Kaka; Ashley Harley; Mornay Isaacs; Richard Isabirye; Wilber Ishemunyoro; Tom Jacobs; Lungile Jafta; Nasir Jamil; Anita Janse Janse van Rensburg; Vinesh Jeaven; Maria José Mellado Peña; Gonzague Jourdain; Katabalwa Juliet; Thidarat Jumpimai; Raungwit Junkaew; Thidarat Jupimai; Winfred Kaahwa; Mildred Kabasonga; Olivia Kaboggoza; Rose Jacqueline Kadhuba; Ampika Kaewbundit; Kanyanee Kaewmamueng; Bosco Kafufu; Brenda Kakayi; Phakamas Kamboua; Suparat Kanjanavanit; Gladys Kasangaki; Naruporn Kasipong; Miriam Kasozi; Chrispus Katemba; Nkata Kekane; Edridah Keminyeto; Woottichai Khamduang; Warunee Khamjakkaew; Jiraporn Khamkon; Sasipass Khannak; Orapin Khatngam; Tassawan Khayanchoomnoom; Busi Khumalo; Mirriam Khunene; Suwimon Khusuwan; Phionah Kibalama; Robinah Kibenge; Anthony Kirabira; Cissy M Kityo; Lameck Kiyimba; Soraya Klinprung; Olivia Kobusingye; Josephine Kobusungye; Areerat Kongponoi; Christoph Königs; Olivier Koole; Christelle Kouakam; Nitinart Krueduangkam; Namthip Kruenual; Nuananong Kunjaroenrut; Raymonds Kyambadde; Priscilla Kyobutungi; Flavia Kyomuhendo; Erinah Kyomukama; Reshma Lakha; Cleopatra Langa; Laddawan Laomanit; Emily Lebotsa; Prattana Leenasirimakul; Lawrence Lekku; Sarah Lensen; Valériane Leroy; Jin Li; Juthamas Limplertjareanwanich; Emma Little; Ezra Lutalo; Jose Luis Jimenez; Hermione Lyall; Candice MacDonald; Gladness Machache; Penelope Madlala; Tryphina Madonsela; Nomfundo Maduna; Joel Maena; Apicha Mahanontharit; Collin Makanga; Candice Makola; Shafic Makumbi; Lucille Malgraaf; Angelous Mamiane; Felicia Mantkowski; Wendy Mapfumo; Laura Marques; Agnes Mary Mugagga; Lindiwe Maseko; Tshepiso Masienyane; Ruth Mathiba; Farai Matimba; Sajeeda Mawlana; Emmanuel Mayanja; Fatima Mayat; Ritah Mbabazi; Nokuthula Mbadaliga; Faith Mbasani; Kathleen McClaughlin; Helen McIlleron; Watchara Meethaisong; Patricia Mendez Garcia; Annet Miwanda; Carlota Miranda; Siphiwe Mkhize; Kgosimang Mmolawa; Rosie Mngqibisa; Fatima Mohamed; Maletsatsi Monametsi; Samuel Montero; Cecilia L Moore; Rejoice Mosia; Columbus Moyo; Mumsy Mthethwa; Shepherd Mudzingwa; Tawona Mudzviti; Hilda Mujuru; Emmanuel Mujyambere; Trust Mukanganiki; Cynthia Mukisa Williams; Mark Mulder; Disan Mulima; Alice Mulindwa; Zivai Mupambireyi; Alba Murciano Cabeza; Herbert Murungi; Dorothy Murungu; Sandra Musarurwa; Victor Musiime; Alex V Musiime; Maria Musisi; Philippa Musoke; Barbara Musoke Nakirya; Godfrey Musoro; Sharif Musumba; Sobia Mustafa; Shirley Mutsai; Phyllis Mwesigwa Rubondo; Mariam Naabalamba; Immaculate Nagawa; Allemah Naidoo; Shamim Nakabuye; Sarah Nakabuye; Sarah Nakalanzi; Justine Nalubwama; Annet Nalugo; Stella Nalusiba; Clementine Namajja; Sylvia Namanda; Paula Namayanja; Esther Nambi; Rachael Kikabi Namuddu; Stella Namukwaya; Florence Namuli; Josephine Namusanje; Rosemary Namwanje; Anusha Nanan-kanjee; Annet Nanduudu; Charity Nankunda; Joanita Nankya Baddokwaya; Maria Nannungi; Winnie Nansamba; Kesdao Nanthapisal; Juliet Nanyonjo; Claire Nasaazi; Helena Nascimento; Eleni Nastouli; Wipaporn Natalie Songtaweesin; Kusum Nathoo; Ian Natuhurira; Rashidah Nazzinda; Thabisa Ncgaba; Milly Ndigendawani; Makhosonke Ndlovu; Georgina Nentsa; Chaiwat Ngampiyaskul; Ntombenhle Ngcobo; Nicole Ngo Giang Huong; Pia Ngwaru; Ruth Nhema; Emily Ninsiima; Gloria Ninsiima; Misheck Nkalo Phiri; Antoni Noguera Julian; Monica Nolan; Thornthun Noppakaorattanamanee; Muzamil Nsibuka Kisekka; Eniola Nsirim; Rashina Nundlal; Rosita Nunes; Lungile Nyantsa; Mandisa Nyati; Sean O'Riordan; Paul Ocitti Labeja; Denis Odoch; Rachel Oguntimehin; Martin Ojok; Geoffrey Onen; Wilma Orange; Pradthana Ounchanum; Benson Ouma; Andreia Padrao; Deborah Pako; Anna Parker; Malgorzata Pasko-Szcech; Reena Patel; Rukchanok Peongjakta; Turian Petpranee; Tasmin Phillips; Jackie Philps; Laura Picault; Sonja Pieterse; Helena Pinheiro; Supawadee Pongprapass; Anton Pozniak; Andrew Prendergast; Luis Prieto Tato; Patcharee Puangmalai; Modiehi Rakgokong; Helena Ramos; Nastassja Ramsagar; Cornelius Rau; Yoann Riault; Pablo Rojo Conejo; Basiimwa Roy Clark; Eddie Rubanga; Baker Rubinga; Chutima Ruklao; Pattira Runarassamee; Chalermpong Saenjum; Chayakorn Saewtrakool; Yacine Saidi; Talia Sainz Costa; Chutima Saisaengjan; Rebecca Sakwa; Tatiana Sarfati; Noshalaza Sbisi; Dihedile Scheppers; Stephan Schultze-Strasser; Ulf Schulze-Sturm; Karen Scott; Janet Seeley; Robert Serunjogi; Leora Sewnarain; Clare Shakeshaft; Subashinie Sidhoo; Mercy Shibemba; Delane Shingadia; Sheleika Singh; Wasna Sirirungsi; Sibongile Sithebe; Theresa Smit; Kurt Smith; Marlize Smuts; Moira Spyer; Worathip Sripaoraya; Warunee Srisuk; Mark Ssenyonga; Patamawadee Sudsaard; Praornsuda Sukrakanchana; Pathanee Tearsansern; Carla Teixeira; Kanchana Than-in-at; Thitiwat Thapwai; Yupawan Thaweesombat; Jutarat Thewsoongnoen; Rodolphe Thiébaut; Margaret Thomason; Laura Thrasyvoulou; Khanungnit Thungkham; Judith Tikabibamu; Gloria Tinago; Ketmookda Trairat; Gareth Tudor-Williams; Mercy Tukamushaba; Deogratiuos Tukwasibwe; Julius Tumusiime; Joana Tuna; Rebecca Turner; Arttasid Udomvised; Aasia Vadee; Hesti Van Huyssteen; Nadine Van Looy; Ebrahim Variava; Yvonne Vaughan-Gordon; Giulio Vecchia; Richard Vowden; Hylke Waalewijn; Rebecca Wampamba; Steve Welch; Ian Weller; Sibusisiwe Weza; Ian White; Kaja Widuch; Helen Wilkes; Sookpanee Wimonklang; Ben Wynne; Pacharaporn Yingyong; Zaam Zinda Nakawungu; Peter Zuidewind

Article de revue

Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial

Anna Turkova, Ellen White, Adeodata R Kekitiinwa, Vivian Mumbiro, Elizabeth Kaudha, Afaaf Liberty, Grace Miriam Ahimbisibwe, Tumelo Moloantoa, Ussanee Srirompotong, Nozibusiso Rejoice Mosia, …

10/2023

Résumé

BACKGROUND: Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and adolescents treated with dolutegravir-based treatment versus alternative antiretroviral therapy. METHODS: This is a secondary analysis of ODYSSEY, an open-label, multicentre, randomised, non-inferiority trial, in which adolescents and children initiating first-line or second-line antiretroviral therapy were randomly assigned 1:1 to dolutegravir-based treatment or standard-of-care treatment. We assessed neuropsychiatric adverse events (reported by clinicians) and responses to the mood and sleep questionnaires (reported by the participant or their carer) in both groups. We compared the proportions of patients with neuropsychiatric adverse events (neurological, psychiatric, and total), time to first neuropsychiatric adverse event, and participant-reported responses to questionnaires capturing issues with mood, suicidal thoughts, and sleep problems. FINDINGS: Between Sept 20, 2016, and June 22, 2018, 707 participants were enrolled, of whom 345 (49%) were female and 362 (51%) were male, and 623 (88%) were Black-African. Of 707 participants, 350 (50%) were randomly assigned to dolutegravir-based antiretroviral therapy and 357 (50%) to non-dolutegravir-based standard-of-care. 311 (44%) of 707 participants started first-line antiretroviral therapy (ODYSSEY-A; 145 [92%] of 157 participants had efavirenz-based therapy in the standard-of-care group), and 396 (56%) of 707 started second-line therapy (ODYSSEY-B; 195 [98%] of 200 had protease inhibitor-based therapy in the standard-of-care group). During follow-up (median 142 weeks, IQR 124–159), 23 participants had 31 neuropsychiatric adverse events (15 in the dolutegravir group and eight in the standard-of-care group; difference in proportion of participants with ≥1 event p=0·13). 11 participants had one or more neurological events (six and five; p=0·74) and 14 participants had one or more psychiatric events (ten and four; p=0·097). Among 14 participants with psychiatric events, eight participants in the dolutegravir group and four in standard-of-care group had suicidal ideation or behaviour. More participants in the dolutegravir group than the standard-of-care group reported symptoms of self-harm (eight vs one; p=0·025), life not worth living (17 vs five; p=0·0091), or suicidal thoughts (13 vs none; p=0·0006) at one or more follow-up visits. Most reports were transient. There were no differences by treatment group in low mood or feeling sad, problems concentrating, feeling worried or feeling angry or aggressive, sleep problems, or sleep quality. INTERPRETATION: The numbers of neuropsychiatric adverse events and reported neuropsychiatric symptoms were low. However, numerically more participants had psychiatric events and reported suicidality ideation in the dolutegravir group than the standard-of-care group. These differences should be interpreted with caution in an open-label trial. Clinicians and policy makers should consider including suicidality screening of children or adolescents receiving dolutegravir.

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Détails

Titre: Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Créateurs - sans rôle: Anna Turkova
Ellen White
Adeodata R Kekitiinwa
Vivian Mumbiro
Elizabeth Kaudha
Afaaf Liberty
Grace Miriam Ahimbisibwe
Tumelo Moloantoa
Ussanee Srirompotong
Nozibusiso Rejoice Mosia
Thanyawee Puthanakit
Robin Kobbe
Clàudia Fortuny
Hajira Kataike
Dickson Bbuye
Sathaporn Na-Rajsima
Alexandra Coelho
Abbas Lugemwa
Mutsa F Bwakura-Dangarembizi
Nigel Klein
Hilda A Mujuru
Cissy Kityo
Mark F Cotton
Rashida A Ferrand
Carlo Giaquinto
Pablo Rojo
Avy Violari
Diana M Gibb
Deborah Ford
Amina Farhana Mehar
Pattamukkil Abraham
Elaine Abrams
Judith Acero
Gerald Muzorah Agaba
Grace Ahimbisibwe
Barbara Ainebyoona
Winnie Akobye
Yasmeen Akhalwaya
Nazim Akoojee
Shabinah S Ali
Pauline Amuge
Catherine Andrea
Maria Angeles Muñoz Fernandez
Rogers Ankunda
Diana Antonia Rutebarika
Suvaporn Anugulruengkitt
Tsitsi Apollo
Moherndran Archary
Ronelle Arendze
Juliet Ategeka
Eunice Atim
Lorna Atwine
Abdel Babiker
Sarah Babirye
Enock Babu
Edward Bagirigomwa
Angella Baita
David Balamusani
Patsy Baliram
David Baliruno
Colin Ball
Henry Balwa
Alasdair Bamford
Srini Bandi
Dominique Barker
Linda Barlow-Mosha
Shazia Begum
Osee Behuhuma
Sarah Bernays
Rogers Besigye
Maria Bester
Joyline Bhiri
Davide Bilardi
Kristien Bird
Pauline Bollen
Chiara Borg
Anne-Marie Borges Da Silva
Jackie Brown
Elena Bruno
Torsak Bunupuradah
David Burger
Nomzamo Buthelezi
Mutsa Bwakura-Dangarembizi
Africanus Byaruhanga
Joanna Calvert
Petronelle Casey
Haseena Cassim
Sphiwee Cebekhulu
Sanuphong Chailert
Suwalai Chalermpantmetagul
Wanna Chamjamrat
Man Chan
Precious Chandiwana
Thannapat Chankun
Sararut Chanthaburanun
Nuttawut Chanto
Ennie Chidziva
Minenhle Chikowore
Joy Chimanzi
Dujrudee Chinwong
Stuart Chitongo
Moses Chitsamatanga
Joshua Choga
Duangrat Chutima
Polly Clayden
Angela Colbers
Alexandra Compagnucci
Ana Constança Mendes
Magda Conway
Jane Crawley
Tim R Cressey
Jacky Crisp
Ana Cristina Matos
Sumaya Dadan
Jacqui Daglish
Siva Danaviah
Tseleng Daniel
Anita De Rossi
Sukanda Denjanta
Els Dobbels
Maria Dowie
Prosper Dube
Benedictor Dube
Nimisha Dudakia
Alice Elwana
Cristina Epalza
David Eram
Juan Erasmus
Peter Erim
Luis Escosa Garcia
Zaakirah Essack
Carolina Estepa
Monica Etima
Alexandre Fernandes
Maite Fernandez
Felicity Fitzgerald
Jacquie Flynn
Claudia Fortuny Guasch
Caroline Foster
George Fourie
Yolandie Fourie
Sophie Foxall
Derusha Frank
Kate Gandhi
India Garcia
Kathleen Gartner
Joshua Gasa
Gugu Gasa
Coral Gomez Rico
Daniel Gomez-Pena
Secrecy Gondo
Anna Goodman
Maria Gorreti Nakalema
Winnie Gozhora
Pisut Greetanukroh
Biobanco Gregorio Maranon
Tiziana Grossele
Shamiso Gwande
Tapiwa Gwaze
Tsitsi Gwenzi
James Hakim
Emmanuel Hakiza
Abdul Hamid Kaka
Ashley Harley
Mornay Isaacs
Richard Isabirye
Wilber Ishemunyoro
Tom Jacobs
Lungile Jafta
Nasir Jamil
Anita Janse Janse van Rensburg
Vinesh Jeaven
Maria José Mellado Peña
Gonzague Jourdain
Katabalwa Juliet
Thidarat Jumpimai
Raungwit Junkaew
Thidarat Jupimai
Winfred Kaahwa
Mildred Kabasonga
Olivia Kaboggoza
Rose Jacqueline Kadhuba
Ampika Kaewbundit
Kanyanee Kaewmamueng
Bosco Kafufu
Brenda Kakayi
Phakamas Kamboua
Suparat Kanjanavanit
Gladys Kasangaki
Naruporn Kasipong
Miriam Kasozi
Chrispus Katemba
Nkata Kekane
Edridah Keminyeto
Woottichai Khamduang
Warunee Khamjakkaew
Jiraporn Khamkon
Sasipass Khannak
Orapin Khatngam
Tassawan Khayanchoomnoom
Busi Khumalo
Mirriam Khunene
Suwimon Khusuwan
Phionah Kibalama
Robinah Kibenge
Anthony Kirabira
Cissy M Kityo
Lameck Kiyimba
Soraya Klinprung
Olivia Kobusingye
Josephine Kobusungye
Areerat Kongponoi
Christoph Königs
Olivier Koole
Christelle Kouakam
Nitinart Krueduangkam
Namthip Kruenual
Nuananong Kunjaroenrut
Raymonds Kyambadde
Priscilla Kyobutungi
Flavia Kyomuhendo
Erinah Kyomukama
Reshma Lakha
Cleopatra Langa
Laddawan Laomanit
Emily Lebotsa
Prattana Leenasirimakul
Lawrence Lekku
Sarah Lensen
Valériane Leroy
Jin Li
Juthamas Limplertjareanwanich
Emma Little
Ezra Lutalo
Jose Luis Jimenez
Hermione Lyall
Candice MacDonald
Gladness Machache
Penelope Madlala
Tryphina Madonsela
Nomfundo Maduna
Joel Maena
Apicha Mahanontharit
Collin Makanga
Candice Makola
Shafic Makumbi
Lucille Malgraaf
Angelous Mamiane
Felicia Mantkowski
Wendy Mapfumo
Laura Marques
Agnes Mary Mugagga
Lindiwe Maseko
Tshepiso Masienyane
Ruth Mathiba
Farai Matimba
Sajeeda Mawlana
Emmanuel Mayanja
Fatima Mayat
Ritah Mbabazi
Nokuthula Mbadaliga
Faith Mbasani
Kathleen McClaughlin
Helen McIlleron
Watchara Meethaisong
Patricia Mendez Garcia
Annet Miwanda
Carlota Miranda
Siphiwe Mkhize
Kgosimang Mmolawa
Rosie Mngqibisa
Fatima Mohamed
Maletsatsi Monametsi
Samuel Montero
Cecilia L Moore
Rejoice Mosia
Columbus Moyo
Mumsy Mthethwa
Shepherd Mudzingwa
Tawona Mudzviti
Hilda Mujuru
Emmanuel Mujyambere
Trust Mukanganiki
Cynthia Mukisa Williams
Mark Mulder
Disan Mulima
Alice Mulindwa
Zivai Mupambireyi
Alba Murciano Cabeza
Herbert Murungi
Dorothy Murungu
Sandra Musarurwa
Victor Musiime
Alex V Musiime
Maria Musisi
Philippa Musoke
Barbara Musoke Nakirya
Godfrey Musoro
Sharif Musumba
Sobia Mustafa
Shirley Mutsai
Phyllis Mwesigwa Rubondo
Mariam Naabalamba
Immaculate Nagawa
Allemah Naidoo
Shamim Nakabuye
Sarah Nakabuye
Sarah Nakalanzi
Justine Nalubwama
Annet Nalugo
Stella Nalusiba
Clementine Namajja
Sylvia Namanda
Paula Namayanja
Esther Nambi
Rachael Kikabi Namuddu
Stella Namukwaya
Florence Namuli
Josephine Namusanje
Rosemary Namwanje
Anusha Nanan-kanjee
Annet Nanduudu
Charity Nankunda
Joanita Nankya Baddokwaya
Maria Nannungi
Winnie Nansamba
Kesdao Nanthapisal
Juliet Nanyonjo
Claire Nasaazi
Helena Nascimento
Eleni Nastouli
Wipaporn Natalie Songtaweesin
Kusum Nathoo
Ian Natuhurira
Rashidah Nazzinda
Thabisa Ncgaba
Milly Ndigendawani
Makhosonke Ndlovu
Georgina Nentsa
Chaiwat Ngampiyaskul
Ntombenhle Ngcobo
Nicole Ngo Giang Huong
Pia Ngwaru
Ruth Nhema
Emily Ninsiima
Gloria Ninsiima
Misheck Nkalo Phiri
Antoni Noguera Julian
Monica Nolan
Thornthun Noppakaorattanamanee
Muzamil Nsibuka Kisekka
Eniola Nsirim
Rashina Nundlal
Rosita Nunes
Lungile Nyantsa
Mandisa Nyati
Sean O'Riordan
Paul Ocitti Labeja
Denis Odoch
Rachel Oguntimehin
Martin Ojok
Geoffrey Onen
Wilma Orange
Pradthana Ounchanum
Benson Ouma
Andreia Padrao
Deborah Pako
Anna Parker
Malgorzata Pasko-Szcech
Reena Patel
Rukchanok Peongjakta
Turian Petpranee
Tasmin Phillips
Jackie Philps
Laura Picault
Sonja Pieterse
Helena Pinheiro
Supawadee Pongprapass
Anton Pozniak
Andrew Prendergast
Luis Prieto Tato
Patcharee Puangmalai
Modiehi Rakgokong
Helena Ramos
Nastassja Ramsagar
Cornelius Rau
Yoann Riault
Pablo Rojo Conejo
Basiimwa Roy Clark
Eddie Rubanga
Baker Rubinga
Chutima Ruklao
Pattira Runarassamee
Chalermpong Saenjum
Chayakorn Saewtrakool
Yacine Saidi
Talia Sainz Costa
Chutima Saisaengjan
Rebecca Sakwa
Tatiana Sarfati
Noshalaza Sbisi
Dihedile Scheppers
Stephan Schultze-Strasser
Ulf Schulze-Sturm
Karen Scott
Janet Seeley
Robert Serunjogi
Leora Sewnarain
Clare Shakeshaft
Subashinie Sidhoo
Mercy Shibemba
Delane Shingadia
Sheleika Singh
Wasna Sirirungsi
Sibongile Sithebe
Theresa Smit
Kurt Smith
Marlize Smuts
Moira Spyer
Worathip Sripaoraya
Warunee Srisuk
Mark Ssenyonga
Patamawadee Sudsaard
Praornsuda Sukrakanchana
Pathanee Tearsansern
Carla Teixeira
Kanchana Than-in-at
Thitiwat Thapwai
Yupawan Thaweesombat
Jutarat Thewsoongnoen
Rodolphe Thiébaut
Margaret Thomason
Laura Thrasyvoulou
Khanungnit Thungkham
Judith Tikabibamu
Gloria Tinago
Ketmookda Trairat
Gareth Tudor-Williams
Mercy Tukamushaba
Deogratiuos Tukwasibwe
Julius Tumusiime
Joana Tuna
Rebecca Turner
Arttasid Udomvised
Aasia Vadee
Hesti Van Huyssteen
Nadine Van Looy
Ebrahim Variava
Yvonne Vaughan-Gordon
Giulio Vecchia
Richard Vowden
Hylke Waalewijn
Rebecca Wampamba
Steve Welch
Ian Weller
Sibusisiwe Weza
Ian White
Kaja Widuch
Helen Wilkes
Sookpanee Wimonklang
Ben Wynne
Pacharaporn Yingyong
Zaam Zinda Nakawungu
Peter Zuidewind
Éditeur: Elsevier BV
Identifiants: 99147944009311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article