Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension

Frédéric Perros; Benoît Ranchoux; Mohamed Izikki; Sana Bentebbal; Chris Happé; Fabrice Antigny; Philippe Jourdon; Peter Dorfmüller; Florence Lecerf; Elie Fadel; Gérald Simonneau; Marc Humbert; Harm Jan Bogaard; Saadia Eddahibi

doi:10.1016/j.jacc.2014.11.050

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Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension

Journal article

Peer reviewed

Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension

Frédéric Perros, Benoît Ranchoux, Mohamed Izikki, Sana Bentebbal, Chris Happé, Fabrice Antigny, Philippe Jourdon, Peter Dorfmüller, Florence Lecerf, Elie Fadel, …

Journal of the American College of Cardiology, Vol.65(7), pp.668 - 680

02/2015

DOI: https://doi.org/10.1016/j.jacc.2014.11.050

PMID: 25677428

Abstract

endothelial dysfunction

inflammation

nebivolol

pulmonary hypertension

β-blocker

Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting vasoconstriction, smooth muscle proliferation, and inflammation.

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Title: Nebivolol for Improving Endothelial Dysfunction, Pulmonary Vascular Remodeling, and Right Heart Function in Pulmonary Hypertension
Creators - without role: Frédéric Perros - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Benoît Ranchoux - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Mohamed Izikki - Laboratory of Fundamental and Applied Bioenergetics
Sana Bentebbal - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Chris Happé - Pulmonary Associates
Fabrice Antigny - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Philippe Jourdon - Institut du Thorax
Peter Dorfmüller - Bicêtre Hospital
Florence Lecerf - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Elie Fadel - Centre Chirurgical Marie Lannelongue
Gérald Simonneau - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Marc Humbert - Hypertension pulmonaire : physiopathologie et innovation thérapeutique
Harm Jan Bogaard - Amsterdam UMC Location VUmc
Saadia Eddahibi - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Publication Details: Journal of the American College of Cardiology, Vol.65(7), pp.668 - 680
Identifiers: 9939513709311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-01763162