Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Nikaïa Smith; Nicolas Pietrancosta; Sophia Davidson; Jacques Dutrieux; Lise Chauveau; Pasquale Cutolo; Michel Dy; Daniel Scott-Algara; Bénédicte Manoury; Onofrio Zirafi; Isabelle Mccort; Thierry Durroux; Françoise Bachelerie; Olivier Schwartz; Jan Münch; Andreas Wack; Sébastien Nisole; Jean-Philippe Herbeuval

doi:10.1038/ncomms14253

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Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

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Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, …

Nature Communications, Vol.8

09/02/2017

DOI: https://doi.org/10.1038/ncomms14253

PMCID: PMC5309800

PMID: 28181493

Abstract

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.

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Title: Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
Creators - without role: Nikaïa Smith - Délégation Paris 5
Nicolas Pietrancosta - Délégation Paris 5
Sophia Davidson - The Francis Crick Institute
Jacques Dutrieux - Toxicologie, Pharmacologie et Signalisation Cellulaire
Lise Chauveau - Immunité et Cancer
Pasquale Cutolo - Inserm
Michel Dy - Assistance Publique – Hôpitaux de Paris
Daniel Scott-Algara - Régulation des Infections Rétrovirales
Bénédicte Manoury - Délégation Paris 5
Onofrio Zirafi - University Hospital Ulm
Isabelle Mccort - Laboratoire de Chimie
Thierry Durroux - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Françoise Bachelerie - Inserm
Olivier Schwartz - Immunité et Cancer
Jan Münch - University Hospital Ulm
Andreas Wack - The Francis Crick Institute
Sébastien Nisole - Toxicologie, Pharmacologie et Signalisation Cellulaire
Jean-Philippe Herbeuval - Laboratoire de Chimie
Publication Details: Nature Communications, Vol.8
Grant note: F.B. and T.D. are supported by the European Consortium Oncornet (HORIZON 2020 MSCA–ITN–2014–ETN–Project 641833 ONCORNET). We also thank Dr Olivier Neyrolles’s and his team and particularly Dr Geanncarlo Lugo for technical discussion about siRNA in DC. This work was supported by SIDACTION and by the Agence National de la Recherche sur le SIDA et les Hépatites (ANRS DFAAP 2016-1 and SF/MB/no.817), by SIDACTION (AI21-1/01732), by the UK Medical Research Council (U117597139) and the Francis Crick Institute which receives its core funding from Cancer Research UK (FC001206) (S.D., A.W.), as well as the Agence nationale de Recherche (Investissements d’Avenir-ANR-10-LABX-0033-LERMIT) grant (F.B., P.C.) and fellowship (P.C.).
Identifiers: 9937574809311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-02075366