National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011

Diane Descamps; Lambert Assoumou; Marie-Laure Chaix; Antoine Chaillon; Sophie Pakianather; Alexis de Rougemont; Alexandre Storto; Georges Dos Santos; Anne Krivine; Constance Delaugerre; Brigitte Montes; Jacques Izopet; Charlotte Charpentier; Marc Wirden; Anne Maillard; Laurence Morand-Joubert; Coralie Pallier; Jean-Christophe Plantier; Jérô Me Guinard; Catherine Tamalet; Jacqueline Cottalorda; Anne-Geneviève Marcelin; Delphine Desbois; Cécile Henquell; Vincent Calvez; Francoise Brun-Vézinet; Bernard Masquelier; Dominique Costagliola; E. Lagier; C. Roussel; H. Le Guillou-Guillemette; C. Alloui; D. Bettinger; G. Anies; S. Reigadas; P. Bellecave; P. Pinson-Recordon; H. Fleury; S. Vallet; M. Leroux; J. Dina; A. Vabret; J. Poveda; A. Mirand; M. Bouvier-Alias; C. Noël; G. dos Santos; S. Yerly; C. Gaille; W. Caveng; S. Chapalay; A. Calmy; A. Signori-Schmuck; P. Morand; L. Bocket; L. Mouna; S. Ranger-Rogez; P. Andre; J. Tardy; M. Trabaud; C. Delamare; E. Schvoerer; E. André-Garnier; V. Ferre; A. Guigon; J. Guinard; G. Peytavin; F. Brun-Vezinet; S. Haim-Boukobza; A. Roques; C. Soulie; S. Lambert-Niclot; I. Malet; S. Fourati; A.-G. Marcelin; P. Flandre; V. Schneider; C. Amiel; G. Giraudeau; S. Fafi-Kremer; M. Schmitt; S. Raymond; F. Barin; S. Marque Juillet

doi:10.1093/jac/dkt238

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National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011

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National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011

Diane Descamps, Lambert Assoumou, Marie-Laure Chaix, Antoine Chaillon, Sophie Pakianather, Alexis de Rougemont, Alexandre Storto, Georges Dos Santos, Anne Krivine, Constance Delaugerre, …

Journal of Antimicrobial Chemotherapy, Vol.68(11), pp.2626-2631

16/10/2013

DOI: https://doi.org/10.1093/jac/dkt238

Abstract

prevalence

resistance survey

HIV-1

réseau de surveillance

virus de l'immunodéficience humaine

effet antirétroviral

infection chronique

prévalence

résistance aux médicaments

épidémiologie

France

Objectives: As recommended by the French ANRS programme for the surveillance of HIV-1 resistance, we estimated the prevalence of transmitted drug resistance-associated mutations (RAMs) in antiretroviral-naive, chronically HIV-1-infected patients. Methods: RAMs were sought in samples from 661 newly diagnosed HIV-1-infected patients in 2010/11 at 36 HIVclinical care centres. Weighted analyses were used to derive representative estimates of the percentage of patients with RAMs. Results: At patient inclusion, the prevalence of virus with protease (PR) or reverse transcriptase (RT) RAMs was 9.0% (95% CI 6.8%-11.2%). No integrase RAMs were observed. The prevalences of protease inhibitor, nucleoside RT inhibitor and non-nucleoside RT inhibitor RAMs were 1.8%, 6.2% and 2.4%, respectively. Resistance to one, two and three classes of antiretroviral agent was observed in 7.9%, 0.9% and 0.2% of patients, respectively. The frequency of RAMs was higher in patients infected with B compared with non-B subtype virus (11.9% versus 5.1%, P¼0.003). Baseline characteristics (gender, age, country of transmission, CD4 cell count and viral load) were not associated with the prevalence of transmitted RAMs. However, men having sex with men (MSM) were more frequently infected with resistant virus than were other transmission groups (12.5% versus 5.8%, P¼0.003). Compared with the 2006/07 survey, the overall prevalence of resistance remained stable. However, a significant decrease in the frequency of virus with PR RAMs was observed in 2010/11 compared with the 2006/07 survey (1.8% versus 5.0%, P¼0.003). Conclusions: In France in 2010/11, the global prevalence of transmitted drug-resistant variants was 9.0%, and the prevalence was stable compared with the 2006/07 survey. MSM and B subtype-infected patients are the groups with a higher prevalence of drug resistance.

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Title: National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011
Creators - without role: Diane Descamps - Virologie
Lambert Assoumou - Virologie
Marie-Laure Chaix - Virologie
Antoine Chaillon - Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents
Sophie Pakianather - Virologie
Alexis de Rougemont - Université de Bourgogne
Alexandre Storto - Virologie
Georges Dos Santos
Anne Krivine - Virologie
Constance Delaugerre - Université Paris Cité
Brigitte Montes - Centre Hospitalier Universitaire de Montpellier
Jacques Izopet - Centre de Physiopathologie Toulouse Purpan
Charlotte Charpentier - Institut de Virologie
Marc Wirden - Assistance Publique – Hôpitaux de Paris
Anne Maillard - Centre Hospitalier Universitaire de Rennes
Laurence Morand-Joubert - Hôpital Saint-Antoine
Coralie Pallier - Institut Mondor de Recherche Biomédicale
Jean-Christophe Plantier - Virologie
Jérô Me Guinard
Catherine Tamalet - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
Jacqueline Cottalorda - Ecology and Conservation Science for Sustainable Seas
Anne-Geneviève Marcelin
Delphine Desbois - Service de microbiologie
Cécile Henquell - Laboratoire Microorganismes Génome et Environnement
Vincent Calvez - institut Camille-Jordan
Francoise Brun-Vézinet - Université Claude Bernard Lyon 1
Bernard Masquelier - Centre Hospitalier Universitaire de Bordeaux
Dominique Costagliola - Inserm
E. Lagier - Centre Hospitalier Universitaire de Bordeaux
C. Roussel - UR 0420 - Station de pathologie végétale
H. Le Guillou-Guillemette - Centre Hospitalier Universitaire d'Angers
C. Alloui - Inserm
D. Bettinger - Centre Hospitalier Universitaire de Besançon
G. Anies - Université Paris Cité
S. Reigadas - Laboratoire de Microbiologie Fondamentale et Pathogénicité
P. Bellecave - Laboratoire de Microbiologie Fondamentale et Pathogénicité
P. Pinson-Recordon - Hôpital Paul-Brousse
H. Fleury - Institut de Virologie
S. Vallet - Laboratoire Universitaire de Biodiversité et Ecologie Microbienne
M. Leroux - Centre de Recherche sur l'Hétéro-Epitaxie et ses Applications
J. Dina - Université de Caen Normandie
A. Vabret - Centre Hospitalier Universitaire de Caen
J. Poveda
A. Mirand - Centre Hospitalier Universitaire de Clermont-Ferrand
M. Bouvier-Alias - Institut Mondor de Recherche Biomédicale
C. Noël - Hôpital Claude Huriez
G. dos Santos - Inserm
S. Yerly - Inserm
C. Gaille - Université Paris Cité
W. Caveng - Sorbonne Université
S. Chapalay - Université Paris Cité
A. Calmy - University Hospital of Geneva
A. Signori-Schmuck - Unit of Virus Host Cell Interactions
P. Morand - Institut de Biologie et de Chimie des Protéines
L. Bocket - Sorbonne Université
L. Mouna - Université Paris Cité
S. Ranger-Rogez - Inserm
P. Andre - Laboratoire d'informatique de Nantes Atlantique
J. Tardy - Institut de Microélectronique, Electromagnétisme et Photonique
M. Trabaud - Sorbonne Université
C. Delamare - Université Paris Cité
E. Schvoerer - Virologie
E. André-Garnier - Hôtel-Dieu de Nantes
V. Ferre - Centre Hospitalier Universitaire de Nantes
A. Guigon
J. Guinard - Centre hospitalier régional d'Orléans
G. Peytavin - Infection, Anti-microbiens, Modélisation, Evolution
F. Brun-Vezinet - Université Claude Bernard Lyon 1
S. Haim-Boukobza - Inserm
A. Roques - Inserm
C. Soulie - Centre de Recherches Pétrographiques et Géochimiques
S. Lambert-Niclot - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
I. Malet
S. Fourati - Laboratoire de Probabilités et Modèles Aléatoires
A.-G. Marcelin - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
P. Flandre - Centre Hospitalier Universitaire de Montpellier
V. Schneider - Surface
C. Amiel - Equipe de Recherche en Physico-Chimie et Biotechnologie
G. Giraudeau - Université Paris Cité
S. Fafi-Kremer - Inserm
M. Schmitt - Hôpital Bichat-Claude-Bernard
S. Raymond - CEA Grenoble
F. Barin - Morphogénèse et antigénicité du VIH, des Virus des Hépatites et Emergents
S. Marque Juillet
Publication Details: Journal of Antimicrobial Chemotherapy, Vol.68(11), pp.2626-2631
Grant note: Agence nationale de recherches sur le sida et les hepatites virales (ANRS) ; European Community's Seventh Framework Programme (FP7/07–2013) under the project ‘Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN)’ (grant no. 223131)
Identifiers: 9941087909311
Academic Unit: Université de Montpellier
Language: English
Resource Type: Journal article
Local Fields: hal-02291004