Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Hanna M Ollila; Eilon Sharon; Ling Lin; Nasa Sinnott-Armstrong; Aditya Ambati; Selina M Yogeshwar; Ryan P Hillary; Otto Jolanki; Juliette Faraco; Mali Einen; Guo Luo; Jing Zhang; Fang Han; Han Yan; Xiao Song Dong; Jing Li; Jun Zhang; Seung-Chul Hong; Tae Won Kim; Yves Dauvilliers; Lucie Barateau; Gert Jan Lammers; Rolf Fronczek; Geert Mayer; Joan Santamaria; Isabelle Arnulf; Stine Knudsen-Heier; May Kristin Lyamouri Bredahl; Per Medbøe Thorsby; Giuseppe Plazzi; Fabio Pizza; Monica Moresco; Catherine Crowe; Stephen K van den Eeden; Michel Lecendreux; Patrice Bourgin; Takashi Kanbayashi; Francisco J Martínez-Orozco; Rosa Peraita-Adrados; Antonio Benetó; Jacques Montplaisir; Alex Desautels; Yu-Shu Huang; Poul Jennum; Sona Nevsimalova; David Kemlink; Alex Iranzo; Sebastiaan Overeem; Aleksandra Wierzbicka; Peter Geisler; Karel Sonka; Makoto Honda; Birgit Högl; Ambra Stefani; Fernando Morgadinho Coelho; Vilma Mantovani; Eva Feketeova; Mia Wadelius; Niclas Eriksson; Hans Smedje; Pär Hallberg; Per Egil Hesla; David Rye; Zerrin Pelin; Luigi Ferini-Strambi; Claudio L Bassetti; Johannes Mathis; Ramin Khatami; Adi Aran; Sheela Nampoothiri; Tomas Olsson; Ingrid Kockum; Markku Partinen; Markus Perola; Birgitte R Kornum; Sina Rueger; Juliane Winkelmann; Taku Miyagawa; Hiromi Toyoda; Seik-Soon Khor; Mihoko Shimada; Katsushi Tokunaga; Manuel Rivas; Jonathan K Pritchard; Neil Risch; Zoltan Kutalik; Ruth O’hara; Joachim Hallmayer; Chun Jimmie Ye; Emmanuel J Mignot; Thomas Damm Als; Adam Ziemann; Ali Abbasi; Anne Lehtonen; Apinya Lertratanakul; Bridget Riley-Gillis; Fedik Rahimov; Howard Jacob; Jeffrey Waring; Mengzhen Liu; Nizar Smaoui; Relja Popovic; Adam Platt; Athena Matakidou; Benjamin Challis; Dirk Paul; Glenda Lassi; Ioanna Tachmazidou; Antti Hakanen; Johanna Schleutker; Nina Pitkänen; Perttu Terho; Petri Virolainen; Arto Mannermaa; Veli-Matti Kosma; Chia-Yen Chen; Heiko Runz; Sally John; Sanni Lahdenperä; Stephanie Loomis; Susan Eaton; George Okafo; Heli Salminen-Mankonen; Marc Jung; Nathan Lawless; Zhihao Ding; Joseph Maranville; Marla Hochfeld; Robert Plenge; Shameek Biswas; Masahiro Kanai; Mutaamba Maasha; Wei Zhou; Outi Tuovila; Raimo Pakkanen; Jari Laukkanen; Teijo Kuopio; Kristiina Aittomäki; Antti Mäkitie; Natalia Pujol; Triin Laisk; Katriina Aalto-Setälä; Johanna Mäkelä; Marco Hautalahti; Sarah Smith; Tom Southerington; Eeva Kangasniemi; Henna Palin; Mika Kähönen; Sanna Siltanen; Tarja Laitinen; Felix Vaura; Jaana Suvisaari; Teemu Niiranen; Veikko Salomaa; Jukka Partanen; Mikko Arvas; Jarmo Ritari; Kati Hyvärinen; David Choy; Edmond Teng; Erich Strauss; Hao Chen; Hubert Chen; Jennifer Schutzman; Julie Hunkapiller; Mark Mccarthy; Natalie Bowers; Rion Pendergrass; Tim Lu; Audrey Chu; Diptee Kulkarni; Fanli Xu; Joanna Betts; John Eicher; Jorge Esparza Gordillo; Laura Addis; Linda Mccarthy; Rajashree Mishra; Janet Kumar; Margaret G Ehm; Kirsi Auro; David Pulford; Anne Pitkäranta; Anu Loukola; Eero Punkka; Malla-Maria Linna; Olli Carpén; Taneli Raivio; Joni A Turunen; Tomi P Mäkelä; Aino Salminen; Antti Aarnisalo; Daniel Gordin; David Rice; Erkki Isometsä; Eveliina Salminen; Heikki Joensuu; Ilkka Kalliala; Johanna Mattson; Juha Sinisalo; Jukka Koskela; Kari Eklund; Katariina Hannula-Jouppi; Lauri Aaltonen; Marja-Riitta Taskinen; Martti Färkkilä; Minna Raivio; Oskari Heikinheimo; Paula Kauppi; Pekka Nieminen; Pentti Tienari; Pirkko Pussinen; Sampsa Pikkarainen; Terhi Ollila; Tiinamaija Tuomi; Timo Hiltunen; Tuomo Meretoja; Tuula Salo; Ulla Palotie; Antti Palomäki; Jenni Aittokallio; Juha Rinne; Kaj Metsärinne; Klaus Elenius; Laura Pirilä; Leena Koulu; Markku Voutilainen; Riitta Lahesmaa; Roosa Kallionpää; Sirkku Peltonen; Tytti Willberg; Ulvi Gursoy; Varpu Jokimaa; Aarno Palotie; Anastasia Kytölä; Andrea Ganna; Anu Jalanko; Aoxing Liu; Arto Lehisto; Awaisa Ghazal; Elina Kilpeläinen; Elisabeth Widen; Elmo Saarentaus; Esa Pitkänen; Hannele Laivuori; Henrike Heyne; Huei-Yi Shen; Jaakko Kaprio; Joel Rämö; Juha Karjalainen; Juha Mehtonen; Jyrki Pitkänen; Kalle Pärn; Kati Donner; Katja Kivinen; L. Elisa Lahtela; Mari E Niemi; Mari Kaunisto; Mart Kals; Mary Pat Reeve; Mervi Aavikko; Nina Mars; Oluwaseun Alexander Dada; Pietro Della Briotta Parolo; Priit Palta; Rigbe Weldatsadik; Risto Kajanne; Rodos Rodosthenous; Samuli Ripatti; Sanni Ruotsalainen; Satu Strausz; Shabbeer Hassan; Shanmukha Sampath Padmanabhuni; Shuang Luo; Susanna Lemmelä; Taru Tukiainen; Timo P Sipilä; Tuomo Kiiskinen; Vincent Llorens; Mark Daly; Jiwoo Lee; Kristin Tsuo; Mitja Kurki; Amanda Elliott; Aki Havulinna; Juulia Partanen; Robert Yang; Dermot Reilly; Alessandro Porello; Amy Hart; Dawn Waterworth; Ekaterina Khramtsova; Karen He; Meijian Guan; Qingqin S Li; Sauli Vuoti; Eric Green; Robert Graham; Sahar Mozaffari; Adriana Huertas-Vazquez; Andrey Loboda; Caroline Fox; Fabiana Farias; Jae-Hoon Sul; Jason Miller; Neha Raghavan; Simonne Longerich; Johannes Kettunen; Raisa Serpi; Reetta Hinttala; Tuomo Mantere; Anne Remes; Elisa Rahikkala; Johanna Huhtakangas; Kaisa Tasanen; Laura Huilaja; Laure Morin-Papunen; Maarit Niinimäki; Marja Vääräsmäki; Outi Uimari; Peeter Karihtala; Terhi Piltonen; Terttu Harju; Timo Blomster; Vuokko Anttonen; Hilkka Soininen; Kai Kaarniranta; Liisa Suominen; Margit Pelkonen; Maria Siponen; Mikko Kiviniemi; Oili Kaipiainen-Seppänen; Päivi Auvinen; Päivi Mäntylä; Reetta Kälviäinen; Valtteri Julkunen; Chris O’donnell; Nicole Renaud; Debby Ngo; Majd Mouded; Mike Mendelson; Anders Mälarstig; Heli Lehtonen; Jaakko Parkkinen; Kirsi Kalpala; Melissa Miller; Nan Bing; Stefan Mcdonough; Xinli Hu; Ying Wu; Airi Jussila; Annika Auranen; Argyro Bizaki-Vallaskangas; Hannu Uusitalo; Jukka Peltola; Jussi Hernesniemi; Katri Kaukinen; Laura Kotaniemi-Talonen; Pia Isomäki; Teea Salmi; Venla Kurra; Kirsi Sipilä; Auli Toivola; Elina Järvensivu; Essi Kaiharju; Hannele Mattsson; Kati Kristiansson; Lotta Männikkö; Markku Laukkanen; Minna Brunfeldt; Päivi Laiho; Regis Wong; Sami Koskelainen; Sini Lähteenmäki; Sirpa Soini; Teemu Paajanen; Terhi Kilpi; Tero Hiekkalinna; Tuuli Sistonen; Clément Chatelain; Deepak Raipal; Katherine Klinger; Samuel Lessard; Fredrik Åberg; Mikko Hiltunen; Sami Heikkinen; Hannu Kankaanranta; Tuula Palotie; Iiris Hovatta; Kimmo Palin; Niko Välimäki; Sanna Toppila-Salmi; Eija Laakkonen; Eeva Sliz; Heidi Silven; Katri Pylkäs; Minna Karjalainen; Riikka Arffman; Susanna Savukoski; Jaakko Tyrmi; Harri Siirtola; Iida Vähätalo; Javier Garcia-Tabuenca; Marianna Niemi; Mika Helminen; Tiina Luukkaala; Hanna Ollila; L Elisa Lahtela; Chris O'Donnell; Ma En Obeidat

doi:10.1038/s41467-023-36120-z

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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Journal article

Open access

Peer reviewed

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Hanna M Ollila, Eilon Sharon, Ling Lin, Nasa Sinnott-Armstrong, Aditya Ambati, Selina M Yogeshwar, Ryan P Hillary, Otto Jolanki, Juliette Faraco, Mali Einen, …

Nature Communications, Vol.14

15/05/2023

DOI: https://doi.org/10.1038/s41467-023-36120-z

PMCID: PMC10185546

PMID: 37188663

Abstract

Genetics

Molecular medicine

Genome-wide association studies

Humans

Autoimmunity

Influenza, Human

Influenza A Virus, H1N1 Subtype

Autoimmune Diseases

Influenza Vaccines

Narcolepsy

Abstract Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.

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Title: Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
Creators - without role: Hanna M Ollila - Stanford University
Eilon Sharon - Stanford University
Ling Lin - Stanford University
Nasa Sinnott-Armstrong - Stanford University
Aditya Ambati - Stanford University
Selina M Yogeshwar - Stanford University
Ryan P Hillary - Stanford University
Otto Jolanki - Stanford University
Juliette Faraco - Stanford University
Mali Einen - Stanford University
Guo Luo - Stanford University
Jing Zhang - Stanford University
Fang Han - Peking University
Han Yan - Peking University People's Hospital
Xiao Song Dong - Peking University People's Hospital
Jing Li - Peking University
Jun Zhang - Peking University People's Hospital
Seung-Chul Hong
Tae Won Kim - St. Vincent's Hospital
Yves Dauvilliers - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Lucie Barateau - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Gert Jan Lammers - Leiden University Medical Center
Rolf Fronczek - Leiden University Medical Center
Geert Mayer - Teva Pharmaceuticals
Joan Santamaria - Universitat de Barcelona
Isabelle Arnulf - Assistance Publique – Hôpitaux de Paris
Stine Knudsen-Heier
May Kristin Lyamouri Bredahl - Oslo University Hospital
Per Medbøe Thorsby - Oslo University Hospital
Giuseppe Plazzi - University of Bologna
Fabio Pizza - University of Bologna
Monica Moresco - University of Bologna
Catherine Crowe - Mater Misericordiae University Hospital
Stephen K van den Eeden - Kaiser Permanente
Michel Lecendreux - Hôpital Robert-Debré
Patrice Bourgin - Université de Strasbourg
Takashi Kanbayashi - Akita University
Francisco J Martínez-Orozco - Hospital Clínico San Carlos
Rosa Peraita-Adrados - Hospital General Universitario Gregorio Marañón
Antonio Benetó
Jacques Montplaisir - Hôpital du Sacré-Cœur de Montréal
Alex Desautels - Hôpital du Sacré-Cœur de Montréal
Yu-Shu Huang
Poul Jennum - Glostrup Hospital
Sona Nevsimalova - Charles University
David Kemlink - Charles University
Alex Iranzo
Sebastiaan Overeem - Eindhoven University of Technology
Aleksandra Wierzbicka - Institute of Psychiatry and Neurology
Peter Geisler - University of Regensburg
Karel Sonka - Charles University
Makoto Honda - Seiwa Hospital
Birgit Högl - Innsbruck Medical University
Ambra Stefani - Innsbruck Medical University
Fernando Morgadinho Coelho - Universidade Federal de São Paulo
Vilma Mantovani - Policlinico S.Orsola-Malpighi
Eva Feketeova - University of Pavol Jozef Šafárik
Mia Wadelius - Science for Life Laboratory
Niclas Eriksson
Hans Smedje - Karolinska Institutet
Pär Hallberg - Science for Life Laboratory
Per Egil Hesla
David Rye - Emory University
Zerrin Pelin - Hasan Kalyoncu University
Luigi Ferini-Strambi - IRCCS Ospedale San Raffaele
Claudio L Bassetti - University Hospital of Bern
Johannes Mathis - University Hospital of Bern
Ramin Khatami - Klinik Barmelweid
Adi Aran - Shaare Zedek Medical Center
Sheela Nampoothiri - Amrita Institute of Medical Sciences and Research Centre
Tomas Olsson - Karolinska Institutet
Ingrid Kockum - Karolinska Institutet
Markku Partinen - University of Helsinki
Markus Perola - Finnish Institute for Health and Welfare
Markus Perola - Finnish Institute for Health and Welfare
Birgitte R Kornum - University of Copenhagen
Sina Rueger - SIB Swiss Institute of Bioinformatics
Juliane Winkelmann - Klinikum rechts der Isar
Taku Miyagawa - The University of Tokyo
Hiromi Toyoda - Tokyo Metropolitan Institute of Medical Science
Seik-Soon Khor
Mihoko Shimada - The University of Tokyo
Katsushi Tokunaga - The University of Tokyo
Manuel Rivas - Stanford University
Manuel Rivas - Stanford University
Jonathan K Pritchard - Stanford University
Neil Risch
Zoltan Kutalik - University of Lausanne
Ruth O’hara - Mental Illness Research, Education and Clinical Centers
Joachim Hallmayer - Mental Illness Research, Education and Clinical Centers
Chun Jimmie Ye - University of California, San Francisco
Emmanuel J Mignot - Stanford University
Thomas Damm Als - Aarhus University
Adam Ziemann - AbbVie
Ali Abbasi - AbbVie
Anne Lehtonen - AbbVie
Apinya Lertratanakul - AbbVie
Bridget Riley-Gillis - AbbVie
Fedik Rahimov - AbbVie
Howard Jacob - AbbVie
Jeffrey Waring - AbbVie
Mengzhen Liu - AbbVie
Nizar Smaoui - AbbVie
Relja Popovic - AbbVie
Adam Platt - AstraZeneca
Athena Matakidou - AstraZeneca
Benjamin Challis - AstraZeneca
Dirk Paul - AstraZeneca
Glenda Lassi - AstraZeneca
Ioanna Tachmazidou - AstraZeneca
Antti Hakanen - University of Turku
Johanna Schleutker - University of Turku
Nina Pitkänen - Varsinais-Suomen Sairaanhoitopiiri
Perttu Terho - University of Turku
Petri Virolainen - Varsinais-Suomen Sairaanhoitopiiri
Arto Mannermaa - Finland University
Veli-Matti Kosma
Chia-Yen Chen
Heiko Runz - Biogen
Sally John - Biogen
Sanni Lahdenperä - Biogen
Stephanie Loomis - Biogen
Susan Eaton - Biogen
George Okafo - Boehringer Ingelheim
Heli Salminen-Mankonen - Boehringer Ingelheim
Marc Jung - Boehringer Ingelheim
Nathan Lawless - Boehringer Ingelheim
Zhihao Ding - Boehringer Ingelheim
Joseph Maranville - Bristol-Myers Squibb
Marla Hochfeld - Bristol-Myers Squibb
Robert Plenge - Boehringer Ingelheim
Shameek Biswas - Bristol-Myers Squibb
Masahiro Kanai - Broad Institute
Mutaamba Maasha - Broad Institute
Wei Zhou - Broad Institute
Outi Tuovila - Business Finland
Raimo Pakkanen - Business Finland
Jari Laukkanen - Central Finland Health Care District
Teijo Kuopio - Central Finland Health Care District
Kristiina Aittomäki - Helsinki University Hospital
Antti Mäkitie - Helsinki University Hospital
Natalia Pujol
Triin Laisk
Katriina Aalto-Setälä - Tampere University
Johanna Mäkelä
Marco Hautalahti
Sarah Smith
Tom Southerington
Eeva Kangasniemi - Tampere University
Henna Palin - Tampere University
Mika Kähönen - Tampere University
Sanna Siltanen - Pirkanmaa Hospital District
Tarja Laitinen - Tampere University
Felix Vaura - Finnish Institute for Health and Welfare
Jaana Suvisaari - Finnish Institute for Health and Welfare
Teemu Niiranen - Finnish Institute for Health and Welfare
Veikko Salomaa - Finnish Institute for Health and Welfare
Jukka Partanen - Finnish Red Cross
Mikko Arvas - Finnish Red Cross
Jarmo Ritari - Finnish Red Cross
Kati Hyvärinen - Finnish Red Cross
David Choy
Edmond Teng
Erich Strauss
Hao Chen
Hubert Chen
Jennifer Schutzman
Julie Hunkapiller
Mark Mccarthy
Natalie Bowers
Rion Pendergrass
Tim Lu
Audrey Chu - GlaxoSmithKline
Diptee Kulkarni - GlaxoSmithKline
Fanli Xu - GlaxoSmithKline
Joanna Betts - GlaxoSmithKline
John Eicher - GlaxoSmithKline
Jorge Esparza Gordillo - GlaxoSmithKline
Laura Addis - GlaxoSmithKline
Linda Mccarthy - GlaxoSmithKline
Rajashree Mishra - GlaxoSmithKline
Janet Kumar - GlaxoSmithKline
Margaret G Ehm - GlaxoSmithKline
Kirsi Auro - Glaxosmithkline
David Pulford - GlaxoSmithKline
Anne Pitkäranta - Hospital District of Helsinki and Uusimaa
Anu Loukola - Hospital District of Helsinki and Uusimaa
Eero Punkka - Hospital District of Helsinki and Uusimaa
Malla-Maria Linna - Hospital District of Helsinki and Uusimaa
Olli Carpén - Hospital District of Helsinki and Uusimaa
Taneli Raivio - Hospital District of Helsinki and Uusimaa
Joni A Turunen - University of Helsinki
Tomi P Mäkelä - University of Helsinki
Aino Salminen - Hospital District of Helsinki and Uusimaa
Antti Aarnisalo - Hospital District of Helsinki and Uusimaa
Daniel Gordin - Hospital District of Helsinki and Uusimaa
David Rice - Hospital District of Helsinki and Uusimaa
Erkki Isometsä - Hospital District of Helsinki and Uusimaa
Eveliina Salminen - Hospital District of Helsinki and Uusimaa
Heikki Joensuu - Hospital District of Helsinki and Uusimaa
Ilkka Kalliala - Hospital District of Helsinki and Uusimaa
Johanna Mattson - Hospital District of Helsinki and Uusimaa
Juha Sinisalo - Hospital District of Helsinki and Uusimaa
Jukka Koskela - Hospital District of Helsinki and Uusimaa
Kari Eklund - Hospital District of Helsinki and Uusimaa
Katariina Hannula-Jouppi - Hospital District of Helsinki and Uusimaa
Lauri Aaltonen - Hospital District of Helsinki and Uusimaa
Marja-Riitta Taskinen
Martti Färkkilä - Hospital District of Helsinki and Uusimaa
Minna Raivio - Hospital District of Helsinki and Uusimaa
Oskari Heikinheimo - Hospital District of Helsinki and Uusimaa
Paula Kauppi
Pekka Nieminen - Hospital District of Helsinki and Uusimaa
Pentti Tienari - Hospital District of Helsinki and Uusimaa
Pirkko Pussinen - Hospital District of Helsinki and Uusimaa
Sampsa Pikkarainen - Hospital District of Helsinki and Uusimaa
Terhi Ollila - Hospital District of Helsinki and Uusimaa
Tiinamaija Tuomi
Timo Hiltunen - Hospital District of Helsinki and Uusimaa
Tuomo Meretoja - Hospital District of Helsinki and Uusimaa
Tuula Salo - Hospital District of Helsinki and Uusimaa
Ulla Palotie - Hospital District of Helsinki and Uusimaa
Antti Palomäki - Varsinais-Suomen Sairaanhoitopiiri
Jenni Aittokallio - Varsinais-Suomen Sairaanhoitopiiri
Juha Rinne - Varsinais-Suomen Sairaanhoitopiiri
Kaj Metsärinne - Varsinais-Suomen Sairaanhoitopiiri
Klaus Elenius - Varsinais-Suomen Sairaanhoitopiiri
Laura Pirilä - Varsinais-Suomen Sairaanhoitopiiri
Leena Koulu - Varsinais-Suomen Sairaanhoitopiiri
Markku Voutilainen - Varsinais-Suomen Sairaanhoitopiiri
Riitta Lahesmaa - Varsinais-Suomen Sairaanhoitopiiri
Roosa Kallionpää - Varsinais-Suomen Sairaanhoitopiiri
Sirkku Peltonen - Varsinais-Suomen Sairaanhoitopiiri
Tytti Willberg - Varsinais-Suomen Sairaanhoitopiiri
Ulvi Gursoy - Varsinais-Suomen Sairaanhoitopiiri
Varpu Jokimaa - Varsinais-Suomen Sairaanhoitopiiri
Aarno Palotie - Institute for Molecular Medicine Finland
Anastasia Kytölä - Institute for Molecular Medicine Finland
Andrea Ganna - Institute for Molecular Medicine Finland
Anu Jalanko - Institute for Molecular Medicine Finland
Aoxing Liu - Institute for Molecular Medicine Finland
Arto Lehisto - Institute for Molecular Medicine Finland
Awaisa Ghazal - University of Helsinki
Elina Kilpeläinen - Institute for Molecular Medicine Finland
Elisabeth Widen - University of Helsinki
Elmo Saarentaus - University of Helsinki
Esa Pitkänen - Institute for Molecular Medicine Finland
Hannele Laivuori - Institute for Molecular Medicine Finland
Henrike Heyne - University of Helsinki
Huei-Yi Shen - Institute for Molecular Medicine Finland
Jaakko Kaprio - Institute for Molecular Medicine Finland
Joel Rämö - University of Helsinki
Juha Karjalainen - Institute for Molecular Medicine Finland
Juha Mehtonen - Institute for Molecular Medicine Finland
Jyrki Pitkänen - University of Helsinki
Kalle Pärn - Institute for Molecular Medicine Finland
Kati Donner - Institute for Molecular Medicine Finland
Katja Kivinen - Institute for Molecular Medicine Finland
L. Elisa Lahtela - Institute for Molecular Medicine Finland
Mari E Niemi - Institute for Molecular Medicine Finland
Mari Kaunisto - Institute for Molecular Medicine Finland
Mart Kals - Institute for Molecular Medicine Finland
Mary Pat Reeve - Institute for Molecular Medicine Finland
Mervi Aavikko - Institute for Molecular Medicine Finland
Nina Mars - University of Helsinki
Oluwaseun Alexander Dada - Institute for Molecular Medicine Finland
Pietro Della Briotta Parolo - University of Helsinki
Priit Palta - Institute for Molecular Medicine Finland
Rigbe Weldatsadik - Institute for Molecular Medicine Finland
Risto Kajanne - Institute for Molecular Medicine Finland
Rodos Rodosthenous - University of Helsinki
Samuli Ripatti - Institute for Molecular Medicine Finland
Sanni Ruotsalainen - Institute for Molecular Medicine Finland
Satu Strausz - Institute for Molecular Medicine Finland
Shabbeer Hassan - Institute for Molecular Medicine Finland
Shanmukha Sampath Padmanabhuni - Institute for Molecular Medicine Finland
Shuang Luo - Institute for Molecular Medicine Finland
Susanna Lemmelä - Institute for Molecular Medicine Finland
Taru Tukiainen - University of Helsinki
Timo P Sipilä - Institute for Molecular Medicine Finland
Tuomo Kiiskinen - Institute for Molecular Medicine Finland
Vincent Llorens - Institute for Molecular Medicine Finland
Mark Daly - University of Helsinki
Jiwoo Lee - Institute for Molecular Medicine Finland
Kristin Tsuo - Institute for Molecular Medicine Finland
Mitja Kurki - Broad Institute
Amanda Elliott - University of Helsinki
Aki Havulinna - Finnish Institute for Health and Welfare
Juulia Partanen - University of Helsinki
Robert Yang - Janssen
Dermot Reilly - Janssen
Alessandro Porello - Janssen
Amy Hart - Janssen
Dawn Waterworth - Janssen
Ekaterina Khramtsova - Janssen
Karen He - Janssen
Meijian Guan - Janssen
Qingqin S Li - Janssen
Sauli Vuoti
Eric Green - Maze
Robert Graham - Maze
Sahar Mozaffari - Maze
Adriana Huertas-Vazquez - Merck & Co., Inc., Rahway, NJ, USA
Andrey Loboda - Merck & Co., Inc., Rahway, NJ, USA
Caroline Fox - Merck & Co., Inc., Rahway, NJ, USA
Fabiana Farias
Jae-Hoon Sul - Merck & Co., Inc., Rahway, NJ, USA
Jason Miller - Merck & Co., Inc., Rahway, NJ, USA
Neha Raghavan - Merck & Co., Inc., Rahway, NJ, USA
Simonne Longerich - Merck & Co., Inc., Rahway, NJ, USA
Johannes Kettunen - Borealis
Raisa Serpi - University of Oulu
Reetta Hinttala - Northern Ostrobothnia Hospital District
Tuomo Mantere - Northern Ostrobothnia Hospital District
Anne Remes - Northern Ostrobothnia Hospital District
Elisa Rahikkala - Northern Ostrobothnia Hospital District
Johanna Huhtakangas - Northern Ostrobothnia Hospital District
Kaisa Tasanen - Northern Ostrobothnia Hospital District
Laura Huilaja - Northern Ostrobothnia Hospital District
Laure Morin-Papunen - Northern Ostrobothnia Hospital District
Maarit Niinimäki - Northern Ostrobothnia Hospital District
Marja Vääräsmäki - Northern Ostrobothnia Hospital District
Outi Uimari - Northern Ostrobothnia Hospital District
Peeter Karihtala - Northern Ostrobothnia Hospital District
Terhi Piltonen - Northern Ostrobothnia Hospital District
Terttu Harju - Northern Ostrobothnia Hospital District
Timo Blomster - Northern Ostrobothnia Hospital District
Vuokko Anttonen - Northern Ostrobothnia Hospital District
Hilkka Soininen
Kai Kaarniranta
Liisa Suominen
Margit Pelkonen
Maria Siponen
Mikko Kiviniemi
Oili Kaipiainen-Seppänen
Päivi Auvinen
Päivi Mäntylä
Reetta Kälviäinen
Valtteri Julkunen
Chris O’donnell - Novartis
Nicole Renaud - Novartis
Debby Ngo - Novartis
Majd Mouded - Novartis
Mike Mendelson - Novartis
Anders Mälarstig - Pfizer
Heli Lehtonen - Pfizer
Jaakko Parkkinen - Pfizer
Kirsi Kalpala - Pfizer
Melissa Miller - Pfizer
Nan Bing - Pfizer
Stefan Mcdonough - Pfizer
Xinli Hu - Pfizer
Ying Wu - Pfizer
Airi Jussila - Pirkanmaa Hospital District
Annika Auranen - Pirkanmaa Hospital District
Argyro Bizaki-Vallaskangas - Pirkanmaa Hospital District
Hannu Uusitalo - Pirkanmaa Hospital District
Jukka Peltola - Pirkanmaa Hospital District
Jussi Hernesniemi - Pirkanmaa Hospital District
Katri Kaukinen - Pirkanmaa Hospital District
Laura Kotaniemi-Talonen - Pirkanmaa Hospital District
Pia Isomäki - Pirkanmaa Hospital District
Teea Salmi - Pirkanmaa Hospital District
Venla Kurra - Pirkanmaa Hospital District
Kirsi Sipilä - University of Oulu
Auli Toivola - Finnish Institute for Health and Welfare
Elina Järvensivu - Finnish Institute for Health and Welfare
Essi Kaiharju - Finnish Institute for Health and Welfare
Hannele Mattsson - Finnish Institute for Health and Welfare
Kati Kristiansson - Finnish Institute for Health and Welfare
Lotta Männikkö - Finnish Institute for Health and Welfare
Markku Laukkanen - Finnish Institute for Health and Welfare
Minna Brunfeldt - Finnish Institute for Health and Welfare
Päivi Laiho - Finnish Institute for Health and Welfare
Regis Wong - Finnish Institute for Health and Welfare
Sami Koskelainen - Finnish Institute for Health and Welfare
Sini Lähteenmäki - Finnish Institute for Health and Welfare
Sirpa Soini - Finnish Institute for Health and Welfare
Teemu Paajanen - Finnish Institute for Health and Welfare
Terhi Kilpi - Finnish Institute for Health and Welfare
Tero Hiekkalinna - Finnish Institute for Health and Welfare
Tuuli Sistonen - Finnish Institute for Health and Welfare
Clément Chatelain
Deepak Raipal
Katherine Klinger
Samuel Lessard
Fredrik Åberg - University of Helsinki
Mikko Hiltunen - University of Eastern Finland
Sami Heikkinen - University of Eastern Finland
Hannu Kankaanranta - University of Gothenburg
Tuula Palotie - Hospital District of Helsinki and Uusimaa
Iiris Hovatta - University of Helsinki
Kimmo Palin - University of Helsinki
Niko Välimäki - University of Helsinki
Sanna Toppila-Salmi - University of Helsinki
Eija Laakkonen - University of Jyväskylä
Eeva Sliz - University of Oulu
Heidi Silven - University of Oulu
Katri Pylkäs - University of Oulu
Minna Karjalainen - University of Oulu
Riikka Arffman - University of Oulu
Susanna Savukoski - University of Oulu
Jaakko Tyrmi - University of Oulu
Harri Siirtola - Tampere University
Iida Vähätalo - Tampere University
Javier Garcia-Tabuenca
Marianna Niemi - Tampere University
Mika Helminen - Tampere University
Tiina Luukkaala - Tampere University
Thomas Damm Als - Aarhus University
Adam Ziemann - AbbVie
Ali Abbasi - AbbVie
Anne Lehtonen - AbbVie
Apinya Lertratanakul - AbbVie
Bridget Riley-Gillis - AbbVie
Fedik Rahimov - AbbVie
Howard Jacob - AbbVie
Jeffrey Waring - AbbVie
Mengzhen Liu - AbbVie
Nizar Smaoui - AbbVie
Relja Popovic - AbbVie
Adam Platt - AstraZeneca
Athena Matakidou - AstraZeneca
Benjamin Challis - AstraZeneca
Dirk Paul - AstraZeneca
Glenda Lassi - AstraZeneca
Ioanna Tachmazidou - AstraZeneca
Antti Hakanen - University of Turku
Johanna Schleutker - University of Turku
Nina Pitkänen - Varsinais-Suomen Sairaanhoitopiiri
Perttu Terho - University of Turku
Petri Virolainen - Varsinais-Suomen Sairaanhoitopiiri
Arto Mannermaa - Finland University
Veli-Matti Kosma
Chia-Yen Chen
Heiko Runz - Biogen
Sally John - Biogen
Sanni Lahdenperä - Biogen
Stephanie Loomis - Biogen
Susan Eaton - Biogen
George Okafo - Boehringer Ingelheim
Heli Salminen-Mankonen - Boehringer Ingelheim
Marc Jung - Boehringer Ingelheim
Nathan Lawless - Boehringer Ingelheim
Zhihao Ding - Boehringer Ingelheim
Joseph Maranville - Bristol-Myers Squibb
Marla Hochfeld - Bristol-Myers Squibb
Robert Plenge - Boehringer Ingelheim
Shameek Biswas - Bristol-Myers Squibb
Masahiro Kanai - Broad Institute
Mutaamba Maasha - Broad Institute
Wei Zhou - Broad Institute
Outi Tuovila - Business Finland
Raimo Pakkanen - Business Finland
Jari Laukkanen - Central Finland Health Care District
Teijo Kuopio - Central Finland Health Care District
Kristiina Aittomäki - Helsinki University Hospital
Antti Mäkitie - Helsinki University Hospital
Natalia Pujol
Triin Laisk
Katriina Aalto-Setälä - Tampere University
Johanna Mäkelä
Marco Hautalahti
Sarah Smith
Tom Southerington
Eeva Kangasniemi - Tampere University
Henna Palin - Tampere University
Mika Kähönen - Tampere University
Sanna Siltanen - Pirkanmaa Hospital District
Tarja Laitinen - Tampere University
Felix Vaura - Finnish Institute for Health and Welfare
Jaana Suvisaari - Finnish Institute for Health and Welfare
Teemu Niiranen - Finnish Institute for Health and Welfare
Veikko Salomaa - Finnish Institute for Health and Welfare
Jukka Partanen - Finnish Red Cross
Mikko Arvas - Finnish Red Cross
Jarmo Ritari - Finnish Red Cross
Kati Hyvärinen - Finnish Red Cross
David Choy
Edmond Teng
Erich Strauss
Hao Chen
Hubert Chen
Jennifer Schutzman
Julie Hunkapiller
Mark Mccarthy
Natalie Bowers
Rion Pendergrass
Tim Lu
Audrey Chu - GlaxoSmithKline
Diptee Kulkarni - GlaxoSmithKline
Fanli Xu - GlaxoSmithKline
Joanna Betts - GlaxoSmithKline
John Eicher - GlaxoSmithKline
Jorge Esparza Gordillo - GlaxoSmithKline
Laura Addis - GlaxoSmithKline
Linda Mccarthy - GlaxoSmithKline
Rajashree Mishra - GlaxoSmithKline
Janet Kumar - GlaxoSmithKline
Margaret G Ehm - GlaxoSmithKline
Kirsi Auro - Glaxosmithkline
David Pulford - GlaxoSmithKline
Anne Pitkäranta - Hospital District of Helsinki and Uusimaa
Anu Loukola - Hospital District of Helsinki and Uusimaa
Eero Punkka - Hospital District of Helsinki and Uusimaa
Malla-Maria Linna - Hospital District of Helsinki and Uusimaa
Olli Carpén - Hospital District of Helsinki and Uusimaa
Taneli Raivio - Hospital District of Helsinki and Uusimaa
Joni A Turunen - University of Helsinki
Tomi P Mäkelä - University of Helsinki
Aino Salminen - Hospital District of Helsinki and Uusimaa
Antti Aarnisalo - Hospital District of Helsinki and Uusimaa
Daniel Gordin - Hospital District of Helsinki and Uusimaa
David Rice - Hospital District of Helsinki and Uusimaa
Erkki Isometsä - Hospital District of Helsinki and Uusimaa
Eveliina Salminen - Hospital District of Helsinki and Uusimaa
Heikki Joensuu - Hospital District of Helsinki and Uusimaa
Ilkka Kalliala - Hospital District of Helsinki and Uusimaa
Johanna Mattson - Hospital District of Helsinki and Uusimaa
Juha Sinisalo - Hospital District of Helsinki and Uusimaa
Jukka Koskela - Hospital District of Helsinki and Uusimaa
Kari Eklund - Hospital District of Helsinki and Uusimaa
Katariina Hannula-Jouppi - Hospital District of Helsinki and Uusimaa
Lauri Aaltonen - Hospital District of Helsinki and Uusimaa
Marja-Riitta Taskinen
Martti Färkkilä - Hospital District of Helsinki and Uusimaa
Minna Raivio - Hospital District of Helsinki and Uusimaa
Oskari Heikinheimo - Hospital District of Helsinki and Uusimaa
Paula Kauppi
Pekka Nieminen - Hospital District of Helsinki and Uusimaa
Pentti Tienari - Hospital District of Helsinki and Uusimaa
Pirkko Pussinen - Hospital District of Helsinki and Uusimaa
Sampsa Pikkarainen - Hospital District of Helsinki and Uusimaa
Terhi Ollila - Hospital District of Helsinki and Uusimaa
Tiinamaija Tuomi
Timo Hiltunen - Hospital District of Helsinki and Uusimaa
Tuomo Meretoja - Hospital District of Helsinki and Uusimaa
Tuula Salo - Hospital District of Helsinki and Uusimaa
Ulla Palotie - Hospital District of Helsinki and Uusimaa
Antti Palomäki - Varsinais-Suomen Sairaanhoitopiiri
Jenni Aittokallio - Varsinais-Suomen Sairaanhoitopiiri
Juha Rinne - Varsinais-Suomen Sairaanhoitopiiri
Kaj Metsärinne - Varsinais-Suomen Sairaanhoitopiiri
Klaus Elenius - Varsinais-Suomen Sairaanhoitopiiri
Laura Pirilä - Varsinais-Suomen Sairaanhoitopiiri
Leena Koulu - Varsinais-Suomen Sairaanhoitopiiri
Markku Voutilainen - Varsinais-Suomen Sairaanhoitopiiri
Riitta Lahesmaa - Varsinais-Suomen Sairaanhoitopiiri
Roosa Kallionpää - Varsinais-Suomen Sairaanhoitopiiri
Sirkku Peltonen - Varsinais-Suomen Sairaanhoitopiiri
Tytti Willberg - Varsinais-Suomen Sairaanhoitopiiri
Ulvi Gursoy - Varsinais-Suomen Sairaanhoitopiiri
Varpu Jokimaa - Varsinais-Suomen Sairaanhoitopiiri
Aarno Palotie - Institute for Molecular Medicine Finland
Anastasia Kytölä - Institute for Molecular Medicine Finland
Andrea Ganna - Institute for Molecular Medicine Finland
Anu Jalanko - Institute for Molecular Medicine Finland
Aoxing Liu - Institute for Molecular Medicine Finland
Arto Lehisto - Institute for Molecular Medicine Finland
Awaisa Ghazal - University of Helsinki
Elina Kilpeläinen - Institute for Molecular Medicine Finland
Elisabeth Widen - University of Helsinki
Elmo Saarentaus - University of Helsinki
Esa Pitkänen - Institute for Molecular Medicine Finland
Hanna Ollila - Stanford University
Hannele Laivuori - Institute for Molecular Medicine Finland
Henrike Heyne - University of Helsinki
Huei-Yi Shen - Institute for Molecular Medicine Finland
Jaakko Kaprio - Institute for Molecular Medicine Finland
Joel Rämö - University of Helsinki
Juha Karjalainen - Institute for Molecular Medicine Finland
Juha Mehtonen - Institute for Molecular Medicine Finland
Jyrki Pitkänen - University of Helsinki
Kalle Pärn - Institute for Molecular Medicine Finland
Kati Donner - Institute for Molecular Medicine Finland
Katja Kivinen - Institute for Molecular Medicine Finland
L Elisa Lahtela - Institute for Molecular Medicine Finland
Mari E Niemi - Institute for Molecular Medicine Finland
Mari Kaunisto - Institute for Molecular Medicine Finland
Mart Kals - Institute for Molecular Medicine Finland
Mary Pat Reeve - Institute for Molecular Medicine Finland
Mervi Aavikko - Institute for Molecular Medicine Finland
Nina Mars - University of Helsinki
Oluwaseun Alexander Dada - Institute for Molecular Medicine Finland
Pietro Della Briotta Parolo
Priit Palta - Institute for Molecular Medicine Finland
Rigbe Weldatsadik - Institute for Molecular Medicine Finland
Risto Kajanne - Institute for Molecular Medicine Finland
Rodos Rodosthenous - University of Helsinki
Samuli Ripatti - Institute for Molecular Medicine Finland
Sanni Ruotsalainen - Institute for Molecular Medicine Finland
Satu Strausz - Institute for Molecular Medicine Finland
Shabbeer Hassan - Institute for Molecular Medicine Finland
Shanmukha Sampath Padmanabhuni - Institute for Molecular Medicine Finland
Shuang Luo - Institute for Molecular Medicine Finland
Susanna Lemmelä - Institute for Molecular Medicine Finland
Taru Tukiainen - University of Helsinki
Timo P Sipilä - Institute for Molecular Medicine Finland
Tuomo Kiiskinen - Institute for Molecular Medicine Finland
Vincent Llorens - Institute for Molecular Medicine Finland
Mark Daly - University of Helsinki
Jiwoo Lee - Institute for Molecular Medicine Finland
Kristin Tsuo - Institute for Molecular Medicine Finland
Mitja Kurki - Broad Institute
Amanda Elliott - University of Helsinki
Aki Havulinna - Finnish Institute for Health and Welfare
Juulia Partanen - University of Helsinki
Robert Yang - Janssen
Dermot Reilly - Janssen
Alessandro Porello - Janssen
Amy Hart - Janssen
Dawn Waterworth - Janssen
Ekaterina Khramtsova - Janssen
Karen He - Janssen
Meijian Guan - Janssen
Qingqin S Li - Janssen
Sauli Vuoti
Eric Green - Maze
Robert Graham - Maze
Sahar Mozaffari - Maze
Adriana Huertas-Vazquez - Merck & Co., Inc., Rahway, NJ, USA
Andrey Loboda - Merck & Co., Inc., Rahway, NJ, USA
Caroline Fox - Merck & Co., Inc., Rahway, NJ, USA
Fabiana Farias
Jae-Hoon Sul - Merck & Co., Inc., Rahway, NJ, USA
Jason Miller - Merck & Co., Inc., Rahway, NJ, USA
Neha Raghavan - Merck & Co., Inc., Rahway, NJ, USA
Simonne Longerich - Merck & Co., Inc., Rahway, NJ, USA
Johannes Kettunen - Borealis
Raisa Serpi - University of Oulu
Reetta Hinttala - Northern Ostrobothnia Hospital District
Tuomo Mantere - Northern Ostrobothnia Hospital District
Anne Remes - Northern Ostrobothnia Hospital District
Elisa Rahikkala - Northern Ostrobothnia Hospital District
Johanna Huhtakangas - Northern Ostrobothnia Hospital District
Kaisa Tasanen - Northern Ostrobothnia Hospital District
Laura Huilaja - Northern Ostrobothnia Hospital District
Laure Morin-Papunen - Northern Ostrobothnia Hospital District
Maarit Niinimäki - Northern Ostrobothnia Hospital District
Marja Vääräsmäki - Northern Ostrobothnia Hospital District
Outi Uimari - Northern Ostrobothnia Hospital District
Peeter Karihtala - Northern Ostrobothnia Hospital District
Terhi Piltonen - Northern Ostrobothnia Hospital District
Terttu Harju - Northern Ostrobothnia Hospital District
Timo Blomster - Northern Ostrobothnia Hospital District
Vuokko Anttonen - Northern Ostrobothnia Hospital District
Hilkka Soininen
Kai Kaarniranta
Liisa Suominen
Margit Pelkonen
Maria Siponen
Mikko Kiviniemi
Oili Kaipiainen-Seppänen
Päivi Auvinen
Päivi Mäntylä
Reetta Kälviäinen
Valtteri Julkunen
Chris O'Donnell
Ma En Obeidat - Novartis
Nicole Renaud - Novartis
Debby Ngo - Novartis
Majd Mouded - Novartis
Mike Mendelson - Novartis
Anders Mälarstig - Pfizer
Heli Lehtonen - Pfizer
Jaakko Parkkinen - Pfizer
Kirsi Kalpala - Pfizer
Melissa Miller - Pfizer
Nan Bing - Pfizer
Stefan Mcdonough - Pfizer
Xinli Hu - Pfizer
Ying Wu - Pfizer
Airi Jussila - Pirkanmaa Hospital District
Annika Auranen - Pirkanmaa Hospital District
Argyro Bizaki-Vallaskangas - Pirkanmaa Hospital District
Hannu Uusitalo - Pirkanmaa Hospital District
Jukka Peltola - Pirkanmaa Hospital District
Jussi Hernesniemi - Pirkanmaa Hospital District
Katri Kaukinen - Pirkanmaa Hospital District
Laura Kotaniemi-Talonen - Pirkanmaa Hospital District
Pia Isomäki - Pirkanmaa Hospital District
Teea Salmi - Pirkanmaa Hospital District
Venla Kurra - Pirkanmaa Hospital District
Kirsi Sipilä - University of Oulu
Auli Toivola - Finnish Institute for Health and Welfare
Elina Järvensivu - Finnish Institute for Health and Welfare
Essi Kaiharju - Finnish Institute for Health and Welfare
Hannele Mattsson - Finnish Institute for Health and Welfare
Kati Kristiansson - Finnish Institute for Health and Welfare
Lotta Männikkö - Finnish Institute for Health and Welfare
Markku Laukkanen - Finnish Institute for Health and Welfare
Markus Perola - Finnish Institute for Health and Welfare
Minna Brunfeldt - Finnish Institute for Health and Welfare
Päivi Laiho - Finnish Institute for Health and Welfare
Regis Wong - Finnish Institute for Health and Welfare
Sami Koskelainen - Finnish Institute for Health and Welfare
Sini Lähteenmäki - Finnish Institute for Health and Welfare
Sirpa Soini - Finnish Institute for Health and Welfare
Teemu Paajanen - Finnish Institute for Health and Welfare
Terhi Kilpi - Finnish Institute for Health and Welfare
Tero Hiekkalinna - Finnish Institute for Health and Welfare
Tuuli Sistonen - Finnish Institute for Health and Welfare
Clément Chatelain
Deepak Raipal
Katherine Klinger
Samuel Lessard
Fredrik Åberg - University of Helsinki
Mikko Hiltunen - University of Eastern Finland
Sami Heikkinen - University of Eastern Finland
Hannu Kankaanranta - University of Gothenburg
Tuula Palotie - Hospital District of Helsinki and Uusimaa
Iiris Hovatta - University of Helsinki
Kimmo Palin - University of Helsinki
Niko Välimäki - University of Helsinki
Sanna Toppila-Salmi - University of Helsinki
Eija Laakkonen - University of Jyväskylä
Eeva Sliz - University of Oulu
Heidi Silven - University of Oulu
Katri Pylkäs - University of Oulu
Minna Karjalainen - University of Oulu
Riikka Arffman - University of Oulu
Susanna Savukoski - University of Oulu
Jaakko Tyrmi - University of Oulu
Manuel Rivas - Stanford University
Harri Siirtola - Tampere University
Iida Vähätalo - Tampere University
Javier Garcia-Tabuenca
Marianna Niemi - Tampere University
Mika Helminen - Tampere University
Tiina Luukkaala - Tampere University
Publication Details: Nature Communications, Vol.14
Identifiers: 9933654009311
Academic Unit: Institut des Neurosciences de Montpellier - INM
Language: English
Resource Type: Journal article
Local Fields: hal-04523091