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Nanobodies: a new paradigm for brain disorder therapies
Article de revue   Avec comité de lecture

Nanobodies: a new paradigm for brain disorder therapies

Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin et Philippe Rondard
Trends in Pharmacological Sciences, Vol.46(11), pp.1049-1051
11/2025
PMID: 41198506

Résumé

camelid single domain antibody immunotherapy schizophrenia allosteric modulator VHH G protein-coupled receptor
Camelid-derived nanobodies offer a promising alternative to conventional antibodies for the treatment of brain disorders. Their current development in models of schizophrenia or Alzheimer's disease highlights their strong therapeutic potential. Optimizing their delivery and ensuring their safety are major challenges, but their modularity and low immunogenicity make them promising candidates for neurotherapy.

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