NF-kappaB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

Nolwenn Coudronniere; Martin Villalba; Nathan Englund; Amnon Altman

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NF-kappaB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

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NF-kappaB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

Nolwenn Coudronniere, Martin Villalba, Nathan Englund et Amnon Altman

Proceedings of the National Academy of Sciences - PNAS, Vol.97(7), p.3394

28/03/2000

Résumé

Immunology

Lymphocytes

Proteins

Protein kinase C-theta(PKCtheta) is a Ca2+-independent member of the PKC family that is selectively expressed in skeletal muscle and T lymphocytes and plays an important role in T cell activation. However, the molecular basis for the important functions of PKCtheta in T cells and the manner in which it becomes coupled to the T cell receptorsignaling machinery are unknown.

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Détails

Titre: NF-kappaB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta
Créateurs - sans rôle: Nolwenn Coudronniere
Martin Villalba
Nathan Englund
Amnon Altman
Détails de publication: Proceedings of the National Academy of Sciences - PNAS, Vol.97(7), p.3394
Éditeur: National Academy of Sciences
Identifiants: 99155740909311
Unité académique: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Langue: English
Type de ressource: Journal article