Myocardial infarction accelerates atherosclerosis

Partha Dutta; Gabriel Courties; Ying Wei; Florian Leuschner; Rostic Gorbatov; Clinton S. Robbins; Yoshiko Iwamoto; Brian Thompson; Alicia L. Carlson; Timo Heidt; Maulik D. Majmudar; Felix Lasitschka; Martin Etzrodt; Peter Waterman; Michael T. Waring; Adam T. Chicoine; Anja M. van der Laan; Hans W. M. Niessen; Jan J. Piek; Barry B. Rubin; Jagdish Butany; James R. Stone; Hugo A. Katus; Sabina A. Murphy; David A. Morrow; Marc S. Sabatine; Claudio Vinegoni; Michael A. Moskowitz; Mikael J. Pittet; Peter Libby; Charles P. Lin; Filip K. Swirski; Ralph Weissleder; Matthias Nahrendorf

doi:10.1038/nature11260

Retour

Myocardial infarction accelerates atherosclerosis

Article de revue

Avec comité de lecture

Myocardial infarction accelerates atherosclerosis

Partha Dutta, Gabriel Courties, Ying Wei, Florian Leuschner, Rostic Gorbatov, Clinton S. Robbins, Yoshiko Iwamoto, Brian Thompson, Alicia L. Carlson, Timo Heidt, …

Nature (London), Vol.487(7407), pp.325-329

19/07/2012

DOI: https://doi.org/10.1038/nature11260

PMID: 22763456

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaques in the arterial wall and cause their rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischaemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, Apoe(-/-) mice developed larger atherosclerotic lesions with a more advanced morphology. This disease acceleration persisted over many weeks and was associated with markedly increased monocyte recruitment. Seeking the source of surplus monocytes in plaques, we found that myocardial infarction liberated haematopoietic stem and progenitor cells from bone marrow niches via sympathetic nervous system signalling. The progenitors then seeded the spleen, yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression.

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Myocardial infarction accelerates atherosclerosis
Créateurs - sans rôle: Partha Dutta - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Gabriel Courties - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Ying Wei - Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Stroke & Neurovasc Regulat Lab, Charlestown, MA 02129 USA
Florian Leuschner - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Rostic Gorbatov - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Clinton S. Robbins - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Yoshiko Iwamoto - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Brian Thompson - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Alicia L. Carlson - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Timo Heidt - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Maulik D. Majmudar - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Felix Lasitschka - Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany
Martin Etzrodt - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Peter Waterman - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Michael T. Waring - MIT & Harvard Massachusetts Gen Hosp, Ragon Inst MGH, Charlestown, MA 02129 USA
Adam T. Chicoine - MIT & Harvard Massachusetts Gen Hosp, Ragon Inst MGH, Charlestown, MA 02129 USA
Anja M. van der Laan - Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands
Hans W. M. Niessen - Vrije Univ Amsterdam Med Ctr, ICaR VU, Dept Pathol & Cardiac Surg, NL-1081 HV Amsterdam, Netherlands
Jan J. Piek - Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands
Barry B. Rubin - Univ Toronto, Toronto Gen Hosp, Peter Munk Cardiac Ctr, Div Vasc Surg, Toronto, ON M5G 2C4, Canada
Jagdish Butany - Univ Toronto, Peter Munk Cardiac Ctr, Dept Pathol, Toronto, ON M5G 2C4, Canada
James R. Stone - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Hugo A. Katus - Med Univ Hosp Heidelberg, Dept Cardiol, D-69120 Heidelberg, Germany
Sabina A. Murphy - Brigham & Womens Hosp, Div Cardiovasc, Dept Med, TIMI Study Grp, Boston, MA 02145 USA
David A. Morrow - Brigham and Women's Hospital
Marc S. Sabatine - Brigham & Womens Hosp, Div Cardiovasc, Dept Med, TIMI Study Grp, Boston, MA 02145 USA
Claudio Vinegoni - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Michael A. Moskowitz - Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Radiol,Stroke & Neurovasc Regulat Lab, Charlestown, MA 02129 USA
Mikael J. Pittet - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Peter Libby - Brigham & Womens Hosp, Dept Med, Div Cardiovasc, Boston, MA 02115 USA
Charles P. Lin - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Filip K. Swirski - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Ralph Weissleder - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Matthias Nahrendorf - Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
Détails de publication: Nature (London), Vol.487(7407), pp.325-329
Éditeur: Springer Nature
Nombre de pages: 5
Note de subvention: P50CA086355 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01EB006432 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) SFB 938/Z2 / Deutsche Forschungsgemeinschaft; German Research Foundation (DFG) R01-HL096576; R01-HL095629; R01-EB006432; T32-CA79443; P50-CA086355 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HL095629 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01AI084880 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
Identifiants: 99141213409311
Unité académique: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Langue: English
Type de ressource: Journal article