Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

David Stucki; Daniela Brites; Leila Jeljeli; Mireia Coscolla; Qingyun Liu; Andrej Trauner; Lukas Fenner; Liliana Rutaihwa; Sonia Borrell; Tao Luo; Qian Gao; Midori Kato-Maeda; Marie Ballif; Matthias Egger; Rita Macedo; Helmi Mardassi; Milagros Moreno; Griselda Tudo Vilanova; Janet Fyfe; Maria Globan; Jackson Thomas; Frances Jamieson; Jennifer L. Guthrie; Adwoa Asante-Poku; Dorothy Yeboah-Manu; Eddie Wampande; Willy Ssengooba; Moses Joloba; W. Henry Boom; Indira Basu; James Bower; Margarida Saraiva; Sidra E. G. Vasconcellos; Philip Suffys; Anastasia Koch; Robert Wilkinson; Linda Gail-Bekker; Bijaya Malla; Serej D. Ley; Hans-Peter Beck; Bouke C. de Jong; Kadri Toit; Elisabeth Sanchez-Padilla; Maryline Bonnet; Ana Gil-Brusola; Matthias Frank; Veronique N. Penlap Beng; Kathleen Eisenach; Issam Alani; Perpetual Wangui Ndung'u; Gunturu Revathi; Florian Gehre; Suriya Akter; Francine Ntoumi; Lynsey Stewart-Isherwood; Nyanda E. Ntinginya; Andrea Rachow; Michael Hoelscher; Daniela Maria Cirillo; Girts Skenders; Sven Hoffner; Daiva Bakonyte; Petras Stakenas; Roland Diel; Valeriu Crudu; Olga Moldovan; Sahal Al-Hajoj; Larissa Otero; Francesca Barletta; E. Jane Carter; Lameck Diero; Philip Supply; Inack Comas; Stefan Niemann; Sebastien Gagneux

doi:10.1038/ng.3704

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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

David Stucki, Daniela Brites, Leila Jeljeli, Mireia Coscolla, Qingyun Liu, Andrej Trauner, Lukas Fenner, Liliana Rutaihwa, Sonia Borrell, Tao Luo, …

Nature genetics, Vol.48(12), pp.1535-1543

01/12/2016

DOI: https://doi.org/10.1038/ng.3704

PMID: 27798628

Résumé

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

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Titre: Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages
Créateurs - sans rôle: David Stucki - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Daniela Brites - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Leila Jeljeli - Forschungszentrum Borstel, Borstel, Germany
Mireia Coscolla - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Qingyun Liu - Fudan Univ, Key Lab Med Mol Virol, Minist Educ, Shanghai, Peoples R China
Andrej Trauner - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Lukas Fenner - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Liliana Rutaihwa - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Sonia Borrell - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Tao Luo - Sichuan Univ, West China Ctr Med Sci, Sch Basic Med Sci, Laborat Infect & Immun, Chengdu, Peoples R China
Qian Gao - Fudan Univ, Key Lab Med Mol Virol, Minist Educ, Shanghai, Peoples R China
Midori Kato-Maeda - Univ Calif San Francisco, Sch Med, San Francisco, CA USA
Marie Ballif - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Matthias Egger - Univ Bern, Inst Social & Prevent Med, Bern, Switzerland
Rita Macedo - Lab Saude Publ, Lisbon, Portugal
Helmi Mardassi - Univ Tunis El Manar, Inst Pasteur Tunis, Tunis, Tunisia
Milagros Moreno - Hosp Nossa Senhora Paz, Cubal, Angola
Griselda Tudo Vilanova - Hosp Clin ISGlobal, Microbiol Serv, Barcelona, Spain
Janet Fyfe - Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia
Maria Globan - Victorian Infect Dis Reference Lab, Melbourne, Vic, Australia
Jackson Thomas - Ifakara Hlth Inst, Bagamoyo, Tanzania
Frances Jamieson - Publ Hlth Ontario, Toronto, ON, Canada
Jennifer L. Guthrie - Publ Hlth Ontario, Toronto, ON, Canada
Adwoa Asante-Poku - Univ Ghana, Noguchi Mem Inst Med Res, Accra, Ghana
Dorothy Yeboah-Manu - University of Ghana
Eddie Wampande - Makerere Univ, Dept Med Microbiol, Kampala, Uganda
Willy Ssengooba - Makerere University
Moses Joloba - Makerere Univ, Dept Med Microbiol, Kampala, Uganda
W. Henry Boom - Case Western Reserve University
Indira Basu - Auckland City Hosp, LabPlus, Auckland, New Zealand
James Bower - Auckland City Hosp, LabPlus, Auckland, New Zealand
Margarida Saraiva - Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal
Sidra E. G. Vasconcellos - Inst Oswaldo Cruz, Rio De Janeiro, Brazil
Philip Suffys - Inst Oswaldo Cruz, Rio De Janeiro, Brazil
Anastasia Koch - Univ Cape Town, Institute Infect Dis & Mol Med, Cape Town, South Africa
Robert Wilkinson - Univ Cape Town, Institute Infect Dis & Mol Med, Cape Town, South Africa
Linda Gail-Bekker - Univ Cape Town, Institute Infect Dis & Mol Med, Cape Town, South Africa
Bijaya Malla - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Serej D. Ley - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Hans-Peter Beck - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Bouke C. de Jong - Inst Trop Med, Antwerp, Belgium
Kadri Toit - Tartu Univ Hosp, United Labs, Mycobacteriol, Tartu, Estonia
Elisabeth Sanchez-Padilla - Epicentre, Dept Clin Res, Paris, France
Maryline Bonnet - Epicentre, Dept Clin Res, Paris, France
Ana Gil-Brusola - Univ Hosp La Fe, Dept Microbiol, Valencia, Spain
Matthias Frank - Univ Tubingen, Inst Trop Med, Tubingen, Germany
Veronique N. Penlap Beng - Univ Yaounde I, Biotechnol Ctr BTC, Inst Lab TB Res LTR, Yaounde, Cameroon
Kathleen Eisenach - Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA
Issam Alani - Fac Med Technol, Dept Med Lab Technol, Baghdad, Iraq
Perpetual Wangui Ndung'u - Jomo Kenyatta Univ Agr & Technol, Inst Trop Med & Infect Dis ITROMID, Nairobi, Kenya
Gunturu Revathi - Aga Khan Univ Hosp, Dept Pathol, Nairobi, Kenya
Florian Gehre - Inst Trop Med, Antwerp, Belgium
Suriya Akter - Inst Trop Med, Antwerp, Belgium
Francine Ntoumi - University of Tübingen
Lynsey Stewart-Isherwood - Univ Witwatersrand, Right Care & Clin HIV Res Unit, Johannesburg, South Africa
Nyanda E. Ntinginya - Mbeya Med Res Ctr NIMR MMRC, Natl Inst Med Res, Mbeya, Tanzania
Andrea Rachow - Ludwig-Maximilians-Universität München
Michael Hoelscher - Ludwig-Maximilians-Universität München
Daniela Maria Cirillo - IRCCS, San Raffaele Sci Inst, Emerging Bacterial Pathogens Unit, Milan, Italy
Girts Skenders - Riga East Univ Hosp, Ctr TB & Lung Dis, Riga, Latvia
Sven Hoffner - Publ Hlth Agcy Sweden, Dept Microbiol, WH0 Supranatl TB Reference Lab, Solna, Sweden
Daiva Bakonyte - Vilnius Univ, Inst Biotechnol, Dept Immunol & Cell Biol, Vilnius, Lithuania
Petras Stakenas - Vilnius Univ, Inst Biotechnol, Dept Immunol & Cell Biol, Vilnius, Lithuania
Roland Diel - Schleswig Holstein Univ Hosp, Inst Epidemiol, Kiel, Germany
Valeriu Crudu - Phthysiopneumol Inst, Natl TB Reference Lab, Kishinev, Moldova
Olga Moldovan - Marius Nasta Pneumophtisiol Inst, Bucharest, Romania
Sahal Al-Hajoj - King Faisal Specialist Hosp & Res Ctr, Dept Infect & Immun, Riyadh, Saudi Arabia
Larissa Otero
Francesca Barletta - Univ Peruana Cayetano Heredia, Instituto Med Trop Alexander von Humboldt, Mol Epidemiol Unit TB, Lima, Peru
E. Jane Carter - Brown Univ, Miriam Hosp, Warren Alpert Sch Med, Providence, RI USA
Lameck Diero - Moi University
Philip Supply - Univ Lille, CNRS, INSERM,U1019,UMR 8204, CHU Lille,Inst Pasteur Lille,Ctr Infect & Immunit, Lille, France
Inack Comas - Ilnst Biomed Valencia IBV CSIC, Valencia, Spain
Stefan Niemann - Forschungszentrum Borstel, Borstel, Germany
Sebastien Gagneux - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Détails de publication: Nature genetics, Vol.48(12), pp.1535-1543
Éditeur: Springer Nature
Nombre de pages: 9
Note de subvention: Novartis Foundation; Novartis 309540-EVODRTB / European Research Council; European Research Council (ERC); European Commission 5U01-AI069924-05 / National Institute of Allergy and Infectious Diseases of the US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) FP7-278864-2 / PathoNgenTrace project 740 / Swiss HIV Cohort Study grant SystemsX.ch 91631301 / Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) German Center for Infection Research (DZIF) FP7-223681 / TB-PAN-NET project 310030_166687; 320030_153442 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF)
Identifiants: 99158530409311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article