Résumé
In this issue of Blood, Alba and colleagues identify key amino acids in adenovirus hexon hypervariable regions that interact with coagulation factor X. By mutating these residues on the adenovirus's major capsid protein in Ad-based vectors, the authors succeed in retargeting gene transfer away from hepatocytes. The advances achieved in this study may create a vector platform that can be used to develop Ad-based therapeutics for nonliver-targeted diseases.