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Multifunctional manganese-doped Prussian blue nanoparticles for two-photon photothermal therapy and magnetic resonance imaging
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Multifunctional manganese-doped Prussian blue nanoparticles for two-photon photothermal therapy and magnetic resonance imaging

Lamiaa M A Ali, Emna Mathlouthi, Marilyn Kajdan, Morgane Daurat, Jérôme Long, Rahima Sidi Boulenouar, Maida Cardoso, Christophe Goze-Bac, Nourredine Amdouni, Yannick Guari, …
Photodiagnosis and Photodynamic Therapy, Vol.22, pp.65 - 69
06/2018
DOI: https://doi.org/10.1016/j.pdpdt.2018.02.015

Résumé

Photo-thermal therapy Two-photon irradiation Photo-thermal agent MRI Multifunctional Cancer cells’ eradication Nanoparticles Prussian blue
Here we demonstrate for the first time that Mn2+-doped Prussian blue nanoparticles of c.a. 70 nm act as effective agents for photothermal therapy under two-photon excitation with an almost total eradication of malignant cells (97 and 98%) at a concentration of 100 μg mL−1 24 h after NIR excitation. This effect combined with interesting longitudinal NMR relaxivity values offer new perspectives for effective imaging and cancer treatment.

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