Abstract
Our case series reports a new immune-related adverse event and highlights three important facts. Firstly, granulomatous reactions not only occur in the skin, but can also affect bones. Secondly, although possibly transient and spontaneously regressive, such lesions may result in protracted functional disabilities owing to their location and the interest of systemic steroids in this setting remains to be established. Finally, they should not be mistaken with an unfavourable evolution of the underlying disease and seem instead to be associated with protracted responses.