Modified oligonucleotides: IV solid phase synthesis and preliminary evaluation of phosphorothioate RNA as potential antisense agents

François Morvan; Bernard Rayner; Jean-Louis Imbach

doi:10.1016/S0040-4039(00)97264-2

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Modified oligonucleotides: IV solid phase synthesis and preliminary evaluation of phosphorothioate RNA as potential antisense agents

Article de revue

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Modified oligonucleotides: IV solid phase synthesis and preliminary evaluation of phosphorothioate RNA as potential antisense agents

François Morvan, Bernard Rayner et Jean-Louis Imbach

Tetrahedron letters, Vol.31(49), pp.7149-7152

1990

DOI: https://doi.org/10.1016/S0040-4039(00)97264-2

Résumé

For the first time a phosphorothioate oligoribonucleotide, namely PS-C 14, has been synthesized on solid support. This modified oligomer is more resistant to enzymatic degradation than the corresponding rC 14 and binds to complementary RNA strands. The phosphorothioate cytidylate, PS-rC 14 has been synthesized. This non natural oligoribonucleotide is more resistant to enzymatic degradation than the natural one and binds to a complementary RNA strand.

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Détails

Titre: Modified oligonucleotides: IV solid phase synthesis and preliminary evaluation of phosphorothioate RNA as potential antisense agents
Créateurs - sans rôle: François Morvan
Bernard Rayner
Jean-Louis Imbach
Détails de publication: Tetrahedron letters, Vol.31(49), pp.7149-7152
Éditeur: Elsevier Ltd
Nombre de pages: 4
Identifiants: 99138900709311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article