Résumé
Background: Physicochemical incompatibilities of parenteral drugs are frequently studied and reported, but are rarely documented for liquid oral drugs. However, in clinical practices, nurses may perform mixtures of several liquid oral formulations. Although such practices are not recommanded, there is a lack of scientific evidence to support this statement. Objective: We aimed to study potential incompatibilities of the most dispensed commercial liquid oral formulations in a psychiatric ward. Methods: First, a bibliographic analysis was performed. Then, 1:1 mixtures of one commercial liquid specialty and tap water and 1:1:1 mixtures of two commercial formulations and water were realized and controlled both visually and analytically. When a precipitate was formed, the mixture was considered incompatible. Results: A table of oral liquid drug incompatibilities was compiled, and the need for pharmaceutical expertise on this subject was discussed. Conclusion: This work is the first report of oral liquid drugs physico-chemical incompatibilities and can lead to an improvement in clinical practices.