Mitotic Golgi Partitioning Is Driven by the Membrane-Fissioning Protein CtBP3/BARS

Cristina Hidalgo Carcedo; Matteo Bonazzi; Stefania Spanò; Gabriele Turacchio; Antonino Colanzi; Alberto Luini; Daniela Corda

doi:10.1126/science.1097775

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Mitotic Golgi Partitioning Is Driven by the Membrane-Fissioning Protein CtBP3/BARS

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Mitotic Golgi Partitioning Is Driven by the Membrane-Fissioning Protein CtBP3/BARS

Cristina Hidalgo Carcedo, Matteo Bonazzi, Stefania Spanò, Gabriele Turacchio, Antonino Colanzi, Alberto Luini et Daniela Corda

Science (American Association for the Advancement of Science), Vol.305(5680), pp.93-96

02/07/2004

DOI: https://doi.org/10.1126/science.1097775

PMID: 15232108

Résumé

Organelle inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G 2 -to-prophase transition of the cell cycle, and hence cell division.

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Titre: Mitotic Golgi Partitioning Is Driven by the Membrane-Fissioning Protein CtBP3/BARS
Créateurs - sans rôle: Cristina Hidalgo Carcedo - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Matteo Bonazzi - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Stefania Spanò - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Gabriele Turacchio - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Antonino Colanzi - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Alberto Luini - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Daniela Corda - Laboratory of Cell Regulation, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy., Laboratory of Membrane Traffic, Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
Détails de publication: Science (American Association for the Advancement of Science), Vol.305(5680), pp.93-96
Nombre de pages: 4
Identifiants: 99155445309311
Unité académique: Institut de Recherche en Infectiologie de Montpellier - IRIM
Langue: English
Type de ressource: Journal article