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Mild and Efficient Trimethylsilylcyanation of Ketones Catalysed by PNP Chloride
Journal article   Peer reviewed

Mild and Efficient Trimethylsilylcyanation of Ketones Catalysed by PNP Chloride

Marie-Agnès Lacour, Nicolas Rahier and Marc Taillefer
Chemistry - A European Journal, Vol.17(44), pp.12276-12279
16/09/2011

Abstract

aldehydes ketones organocatalysts solventfree trimethylsilylcyanation
Mild & green: The commercially and readily available PNPCl behaves as a very effective catalyst for the synthesis of various trimethylsilyl cyanohydrins from a wide range of aliphatic, cyclic, α,β-unsaturated and aromatic ketones. The method proceeds at room temperature in solvent-free conditions, in the presence of very small amounts of catalyst (see scheme).
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