Microglia states and nomenclature: A field at its crossroads

Rosa C Paolicelli; Amanda Sierra; Beth Stevens; Marie-Ève Tremblay; Adriano Aguzzi; Bahareh Ajami; Ido Amit; Etienne Audinat; Ingo Bechmann; Mariko Bennett; Frederick Bennett; Alain Bessis; Knut Biber; Staci Bilbo; Mathew Blurton-Jones; Erik Boddeke; Dora Brites; Bert Brône; Guy C Brown; Oleg Butovsky; Monica J Carson; Bernardo Castellano; Marco Colonna; Sally A Cowley; Colm Cunningham; Dimitrios Davalos; Philip L de Jager; Bart de Strooper; Ádám Dénes; Bart J L Eggen; Ukpong Eyo; Elena Galea; S. Garel; Florent Ginhoux; Christopher K Glass; Ozgun Gokce; Diego Gomez-Nicola; Berta González; Siamon Gordon; Manuel B Graeber; Andrew D Greenhalgh; Pierre Gressens; Melanie Greter; David H Gutmann; Christian Haass; Michael Heneka; Frank L Heppner; Soyon Hong; David A. Hume; Steffen Jung; Helmut Kettenmann; Jonathan Kipnis; Ryuta Koyama; Greg Lemke; Marina Lynch; Ania Majewska; Marzia Malcangio; Tarja Malm; Renzo Mancuso; Takahiro Masuda; Michela Matteoli; Barry W Mccoll; Veronique E Miron; Anna Victoria Molofsky; Michelle Monje; Eva Mracsko; Agnès Nadjar; Jonas J Neher; Urte Neniskyte; Harald Neumann; Mami Noda; Bo Peng; Francesca Peri; V. Hugh Perry; Phillip G Popovich; Clare Pridans; Josef Priller; Marco Prinz; Davide Ragozzino; Richard M Ransohoff; Michael W Salter; Anne Schaefer; Dorothy Schafer; Michal Schwartz; Mikael Simons; Cody J Smith; Wolfgang J Streit; Tuan Leng Tay; Li-Huei Tsai; Alexei Verkhratsky; Rommy von Bernhardi; Hiroaki Wake; Valérie Wittamer; Susanne A Wolf; Long-Jun Wu; Tony Wyss-Coray

doi:10.1016/j.neuron.2022.10.020

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Microglia states and nomenclature: A field at its crossroads

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Microglia states and nomenclature: A field at its crossroads

Rosa C Paolicelli, Amanda Sierra, Beth Stevens, Marie-Ève Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, …

Neuron, Vol.110(21), pp.3458-3483

11/2022

DOI: https://doi.org/10.1016/j.neuron.2022.10.020

PMID: 36327895

Abstract

Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.

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Title: Microglia states and nomenclature: A field at its crossroads
Creators - without role: Rosa C Paolicelli - University of Lausanne
Amanda Sierra - Ikerbasque
Beth Stevens - Boston Children's Hospital
Marie-Ève Tremblay - Centre de recherche du CHU de Québec-Université Laval
Adriano Aguzzi - University of Zurich
Bahareh Ajami - Oregon Health & Science University
Ido Amit - Weizmann Institute of Science
Etienne Audinat - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Ingo Bechmann - Leipzig University
Mariko Bennett - Children's Hospital of Philadelphia
Frederick Bennett - Children's Hospital of Philadelphia
Alain Bessis - Institut de Biologie de l'École Normale Supérieure
Knut Biber - AbbVie
Staci Bilbo - Duke University
Mathew Blurton-Jones - University of California, Irvine
Erik Boddeke - University Medical Center Groningen
Dora Brites - University of Lisbon
Bert Brône - Hasselt University
Guy C Brown - University of Cambridge
Oleg Butovsky - Brigham and Women's Hospital
Monica J Carson - University of California, Riverside
Bernardo Castellano - Universitat Autònoma de Barcelona
Marco Colonna - Washington University in St. Louis
Sally A Cowley - University of Oxford
Colm Cunningham - Trinity College Dublin
Dimitrios Davalos - Cleveland Clinic Lerner College of Medicine
Philip L de Jager - Columbia University Irving Medical Center
Bart de Strooper - UK Dementia Research Institute
Ádám Dénes - HUN-REN Institute of Experimental Medicine
Bart J L Eggen - University of Groningen
Ukpong Eyo - University of Virginia
Elena Galea - Institució Catalana de Recerca i Estudis Avançats
S. Garel - Inserm
Florent Ginhoux - Singapore Immunology Network
Christopher K Glass - University of California, San Diego
Ozgun Gokce - Ludwig-Maximilians-Universität München
Diego Gomez-Nicola - Southampton General Hospital
Berta González - Universitat Autònoma de Barcelona
Siamon Gordon - Chang Gung University
Manuel B Graeber - University of Sydney
Andrew D Greenhalgh - University of Manchester
Pierre Gressens - Université Paris Cité
Melanie Greter - University of Zurich
David H Gutmann - Washington University in St. Louis
Christian Haass - Ludwig-Maximilians-Universität München
Michael Heneka - University of Luxembourg
Frank L Heppner - Charité - Universitätsmedizin Berlin
Soyon Hong - UK Dementia Research Institute
David A. Hume - Mater Research
Steffen Jung - Weizmann Institute of Science
Helmut Kettenmann - Shenzhen Institutes of Advanced Technology
Jonathan Kipnis - Washington University in St. Louis
Ryuta Koyama - The University of Tokyo
Greg Lemke - Salk Institute for Biological Studies
Marina Lynch - Trinity College Dublin
Ania Majewska - University of Rochester
Marzia Malcangio - King's College London
Tarja Malm - University of Eastern Finland
Renzo Mancuso - University of Antwerp
Takahiro Masuda - Kyushu University
Michela Matteoli - National Research Council
Barry W Mccoll - UK Dementia Research Institute
Veronique E Miron - UK Dementia Research Institute
Anna Victoria Molofsky - University of California, San Francisco
Michelle Monje - Howard Hughes Medical Institute
Eva Mracsko - Roche
Agnès Nadjar - Institut Universitaire de France
Jonas J Neher - Hertie Institute for Clinical Brain Research
Urte Neniskyte - Vilnius University
Harald Neumann - University Hospital Bonn
Mami Noda - Kyushu University
Bo Peng - Fudan University
Francesca Peri - University of Zurich
V. Hugh Perry - University of Southampton
Phillip G Popovich - The Ohio State University
Clare Pridans - University of Edinburgh
Josef Priller - Technical University of Munich
Marco Prinz - University of Freiburg
Davide Ragozzino - Fondazione Santa Lucia
Richard M Ransohoff - Third Dimension Technologies
Michael W Salter - University of Toronto
Anne Schaefer - Max Planck Institute for Biology of Ageing
Dorothy Schafer - Neuropsychiatric Research Institute
Michal Schwartz - Weizmann Institute of Science
Mikael Simons - German Center for Neurodegenerative Diseases
Cody J Smith - University of Notre Dame
Wolfgang J Streit - University of Florida
Tuan Leng Tay - Bernstein Center for Computational Neuroscience Freiburg
Li-Huei Tsai - Broad Institute
Alexei Verkhratsky - University of the Basque Country
Rommy von Bernhardi - San Sebastián University
Hiroaki Wake - Nagoya University
Valérie Wittamer - Université Libre de Bruxelles
Susanne A Wolf - Charité - Universitätsmedizin Berlin
Long-Jun Wu - Mayo Clinic
Tony Wyss-Coray - Stanford University
Publication Details: Neuron, Vol.110(21), pp.3458-3483
Grant note: This work was supported by grants from the Dementia Research Switzerland– Synapsis Foundation, Swiss National Science Foundation (SNSF 310030_197940), and European Research Council (ERC StGrant REMIND 804949) to R.C.P.; the Spanish Ministry of Science and Innovation Competitiveness MCIN/AEI/ 10.13039/501100011033 and FEDER ‘‘A way to make Europe’’ (RTI2018099267-B-I00 and RYC-2013-12817), a Tatiana Foundation award (P-048FTPGB 2018), and a Basque Government Department of Education project (PIBA 2020_1_0030) to A.S.; Cure Alzheimer’s Fund and Alzheimer’s Association to B.S.; the Canadian Institutes of Health Research (foundation grant 341846, project grant 461831) and Natural Sciences and Engineering Research Council of Canada (discovery grant RGPIN-2014-05308) to M.E.T. M.E.T. is a Tier II Canada Research Chair in Neurobiology of Aging and Cognition. This work was also funded by DFG CRC/TRR167 ‘‘NeuroMac’’ to I.A., J.P., M.P., and S.J. and by DFG SFB 1052, Project 209933838 to I.B. Australian Research Council support for project DP150104472 to M.B.G. is gratefully acknowledged.
Identifiers: 9934058909311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-03859613