Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012–2018

Pierre Pradat; C Chirouze; C Drobacheff-Thiébaut; A Foltzer; K Bouiller; L Hustache-Mathieu; Q Lepiller; F Bozon; O Babre; A Brunel; P Muret; E Chevalier; C Jacomet; H Laurichesse; O Lesens; M Vidal; N Mrozek; C Aumeran; O Baud; V Corbin; E Goncalvez; A Mirand; A Brebion; C Henquell; I Lamaury; I Fabre; E Curlier; R Ouissa; C Herrmann-Storck; B Tressieres; M Receveur; F Boulard; C Daniel; C Clavel; P Roger; S Markowicz; N Chellum Rungen; D Merrien; P Perré; T Guimard; O Bollangier; S Leautez; M Morrier; L Laine; D Boucher; P Point; Laurent Cotte; F Ader; A Becker; A Boibieux; C Brochier; F Brunel-Dalmas; O Cannesson; P Chiarello; C Chidiac; S Degroodt; T Ferry; M Godinot; J Livrozet; D Makhloufi; P Miailhes; T Perpoint; M Perry; C Pouderoux; Stéphane Roux; C Triffault-Fillit; F Valour; C Charre; V Icard; J Tardy; M Trabaud; I Ravaux; A Ménard; A Belkhir; P Colson; C Dhiver; A Madrid; M Martin-Degioanni; L Meddeb; M Mokhtari; A Motte; A Raoux; C Toméi; H Tissot-Dupont; Isabelle Poizot-Martin; S Brégigeon; O Zaegel-Faucher; V Obry-Roguet; H Laroche; M Orticoni; M Soavi; E Ressiot; M Ducassou; I Jaquet; S Galie; H Colson; A Ritleng; A Ivanova; C Debreux; C Lions; T Rojas-Rojas; André Cabié; S Abel; J Bavay; B Bigeard; O Cabras; L Cuzin; R Dupin de Majoubert; L Fagour; K Guitteaud; A Marquise; F Najioullah; S Pierre-François; J Pasquier; P Richard; K Rome; J Turmel; C Varache; N Atoui; M Bistoquet; E Delaporte; V Le Moing; A Makinson; N Meftah; C Merle de Boever; B Montes; A Montoya Ferrer; E Tuaillon; J Reynes; B Lefèvre; E Jeanmaire; S Hénard; E Frentiu; A Charmillon; A Legoff; N Tissot; M André; L Boyer; M Bouillon; M Delestan; F Goehringer; S Bevilacqua; C Rabaud; T May; F Raffi; C Allavena; O Aubry; E Billaud; C Biron; B Bonnet; S Bouchez; D Boutoille; C Brunet-Cartier; C Deschanvres; B Gaborit; A Grégoire; M Grégoire; O Grossi; R Guéry; Maeva Lefebvre; P Le Turnier; R Lecomte; P Morineau; V Reliquet; S Sécher; M Cavellec; E Paredes; A Soria; V Ferré; E André-Garnier; A Rodallec; Pascal Pugliese; S Breaud; C Ceppi; D Chirio; E Cua; P Dellamonica; E Demonchy; A de Monte; J Durant; C Etienne; S Ferrando; R Garraffo; C Michelangeli; V Mondain; A Naqvi; N Oran; I Perbost; M Carles; C Klotz; A Maka; C Pradier; B Prouvost-Keller; K Risso; V Rio; E Rosenthal; I Touitou; S Wehrlen-Pugliese; G Zouzou; Laurent Hocqueloux; T Prazuck; C Gubavu; A Sève; S Giaché; V Rzepecki; M Colin; C Boulard; G Thomas; A Cheret; C Goujard; Y Quertainmont; E Teicher; N Lerolle; S Jaureguiberry; R Colarino; O Deradji; A Castro; A Barrail-Tran; Y Yazdanpanah; R Landman; V Joly; J Ghosn; C Rioux; S Lariven; A Gervais; F Lescure; S Matheron; F Louni; Z Julia; S Le Gac; C Charpentier; D Descamps; G Peytavin; C Duvivier; C Aguilar; F Alby-Laurent; K Amazzough; G Benabdelmoumen; P Bossi; G Cessot; C Charlier; P Consigny; K Jidar; E Lafont; F Lanternier; J Leporrier; O Lortholary; C Louisin; J Lourenco; P Parize; B Pilmis; C Rouzaud; F Touam; M Valantin; R Tubiana; R Agher; S Seang; L Schneider; R Palich; C Blanc; C Katlama; Firouze Bani-Sadr; J Berger; Y N’guyen; D Lambert; I Kmiec; M Hentzien; A Brunet; J Romaru; H Marty; V Brodard; C Arvieux; P Tattevin; M Revest; F Souala; M Baldeyrou; S Patrat-Delon; J Chapplain; F Benezit; M Dupont; M Poinot; A Maillard; C Pronier; F Lemaitre; C Morlat; M Poisson-Vannier; T Jovelin; J Sinteff; A Gagneux-Brunon; E Botelho-Nevers; A Frésard; V Ronat; F Lucht; David Rey; P Fischer; M Partisani; C Cheneau; M Priester; C Mélounou; C Bernard-Henry; E de Mautort; S Fafi-Kremer; Pierre Delobel; M Alvarez; N Biezunski; A Debard; C Delpierre; G Gaube; P Lansalot; L Lelièvre; M Marcel; G Martin-Blondel; M Piffaut; L Porte; K Saune; O Robineau; F Ajana; E Aïssi; I Alcaraz; E Alidjinou; V Baclet; L Bocket; A Boucher; M Digumber; Thomas Huleux; B Lafon-Desmurs; A Meybeck; M Pradier; M Tetart; P Thill; N Viget; M Valette

doi:10.1093/cid/ciaa1940

Article de revue

Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012–2018

Pierre Pradat, C Chirouze, C Drobacheff-Thiébaut, A Foltzer, K Bouiller, L Hustache-Mathieu, Q Lepiller, F Bozon, O Babre, A Brunel, …

Clinical Infectious Diseases

05/01/2021

DOI: https://doi.org/10.1093/cid/ciaa1940

PMID: 33400777

Résumé

coinfection

hepatitis C virus

human immunodeficiency virus

men having sex with men

microelimination

Abstract Background The arrival of highly effective, well-tolerated, direct-acting antiviral agents (DAA) led to a dramatic decrease in hepatitis C virus (HCV) prevalence. Human immunodeficiency virus (HIV)-HCV–coinfected patients are deemed a priority population for HCV elimination, while a rise in recently acquired HCV infections in men who have sex with men (MSM) has been described. We describe the variations in HIV-HCV epidemiology in the French Dat’AIDS cohort. Methods This was a retrospective analysis of a prospective cohort of persons living with HIV (PLWH) from 2012 to 2018. We determined HCV prevalence, HCV incidence, proportion of viremic patients, treatment uptake, and mortality rate in the full cohort and by HIV risk factors. Results From 2012 to 2018, 50 861 PLWH with a known HCV status were followed up. During the period, HCV prevalence decreased from 15.4% to 13.5%. HCV prevalence among new HIV cases increased from 1.9% to 3.5% in MSM but remained stable in other groups. Recently acquired HCV incidence increased from 0.36/100 person-years to 1.25/100 person-years in MSM. The proportion of viremic patients decreased from 67.0% to 8.9%. MSM became the first group of viremic patients in 2018 (37.9%). Recently acquired hepatitis represented 59.2% of viremic MSM in 2018. DAA treatment uptake increased from 11.4% to 61.5%. More treatments were initiated in MSM in 2018 (41.2%) than in intravenous drug users (35.6%). In MSM, treatment at the acute phase represented 30.0% of treatments in 2018. Conclusions A major shift in HCV epidemiology was observed in PLWH in France from 2012 to 2018, leading to a unique situation in which the major group of HCV transmission in 2018 was MSM. Clinical Trials Registration. NCT02898987.

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Titre: Microelimination or Not? The Changing Epidemiology of Human Immunodeficiency Virus-Hepatitis C Virus Coinfection in France 2012–2018
Créateurs - sans rôle: Pierre Pradat - Hôpital de la Croix-Rousse
C Chirouze - Inserm
C Drobacheff-Thiébaut - Inserm
A Foltzer
K Bouiller
L Hustache-Mathieu - Centre Hospitalier Universitaire de Nice
Q Lepiller - Centre hospitalier universitaire d'Orléans
F Bozon - Centre Hospitalier Universitaire de Reims
O Babre
A Brunel
P Muret
E Chevalier - Inserm
C Jacomet - Centre Hospitalier Universitaire de Martinique
H Laurichesse - Centre Hospitalier de Tourcoing
O Lesens
M Vidal - Economic & Social Sciences, Health Systems & Medical Informatics
N Mrozek - Centre Hospitalier Universitaire de Martinique
C Aumeran - Centre Hospitalier Universitaire de Martinique
O Baud
V Corbin - Hôpitaux Universitaires de Strasbourg
E Goncalvez - Centre Hospitalier Universitaire de Martinique
A Mirand
A Brebion
C Henquell - Inserm
I Lamaury
I Fabre
E Curlier - Centre Hospitalier Universitaire de Martinique
R Ouissa
C Herrmann-Storck - Centre Hospitalier Universitaire de Martinique
B Tressieres - Inserm
M Receveur
F Boulard - Hôpital Robert-Debré
C Daniel - Inserm
C Clavel - Centre Hospitalier Universitaire de Martinique
P Roger
S Markowicz
N Chellum Rungen
D Merrien
P Perré
T Guimard
O Bollangier
S Leautez
M Morrier - Aix-Marseille Université
L Laine - Centre Hospitalier Universitaire de Nice
D Boucher
P Point
Laurent Cotte - Hospices Civils de Lyon
F Ader - Inserm
A Becker
A Boibieux
C Brochier - Centre Hospitalier Universitaire de Martinique
F Brunel-Dalmas - Centre Hospitalier Universitaire de Reims
O Cannesson
P Chiarello
C Chidiac - Inserm
S Degroodt
T Ferry
M Godinot - Inserm
J Livrozet
D Makhloufi
P Miailhes
T Perpoint
M Perry - Institut de Recherche pour le Développement
C Pouderoux - Centre Hospitalier Universitaire de Martinique
Stéphane Roux
C Triffault-Fillit - Inserm
F Valour - Centre Hospitalier Universitaire de Reims
C Charre - Centre Hospitalier Universitaire de Martinique
V Icard - Hôpitaux Universitaires de Strasbourg
J Tardy
M Trabaud - Inserm
I Ravaux
A Ménard
A Belkhir
P Colson
C Dhiver - Inserm
A Madrid
M Martin-Degioanni - Aix-Marseille Université
L Meddeb - Hôpital l'Archet
M Mokhtari
A Motte
A Raoux
C Toméi - Inserm
H Tissot-Dupont - Centre Hospitalier de Tourcoing
Isabelle Poizot-Martin - Hôpital Sainte-Marguerite
S Brégigeon - Institut de Recherche pour le Développement
O Zaegel-Faucher
V Obry-Roguet - Hôpitaux Universitaires de Strasbourg
H Laroche - Centre Hospitalier de Tourcoing
M Orticoni - Inserm
M Soavi
E Ressiot
M Ducassou
I Jaquet
S Galie
H Colson
A Ritleng
A Ivanova
C Debreux
C Lions
T Rojas-Rojas
André Cabié - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
S Abel
J Bavay
B Bigeard
O Cabras
L Cuzin
R Dupin de Majoubert
L Fagour
K Guitteaud
A Marquise
F Najioullah
S Pierre-François
J Pasquier
P Richard
K Rome
J Turmel
C Varache
N Atoui
M Bistoquet
E Delaporte
V Le Moing
A Makinson
N Meftah
C Merle de Boever
B Montes
A Montoya Ferrer
E Tuaillon
J Reynes
B Lefèvre
E Jeanmaire
S Hénard
E Frentiu
A Charmillon
A Legoff
N Tissot
M André
L Boyer
M Bouillon
M Delestan
F Goehringer
S Bevilacqua
C Rabaud
T May
F Raffi
C Allavena
O Aubry
E Billaud
C Biron
B Bonnet
S Bouchez
D Boutoille
C Brunet-Cartier
C Deschanvres
B Gaborit
A Grégoire
M Grégoire
O Grossi
R Guéry
Maeva Lefebvre - Centre d'Investigation Clinique de Nantes
P Le Turnier
R Lecomte
P Morineau
V Reliquet
S Sécher
M Cavellec
E Paredes
A Soria
V Ferré
E André-Garnier
A Rodallec
Pascal Pugliese - Centre Hospitalier Universitaire de Nice
S Breaud
C Ceppi
D Chirio
E Cua
P Dellamonica
E Demonchy
A de Monte
J Durant
C Etienne
S Ferrando
R Garraffo
C Michelangeli
V Mondain
A Naqvi
N Oran
I Perbost
M Carles
C Klotz
A Maka
C Pradier
B Prouvost-Keller
K Risso
V Rio
E Rosenthal
I Touitou
S Wehrlen-Pugliese
G Zouzou
Laurent Hocqueloux - Centre hospitalier universitaire d'Orléans
T Prazuck
C Gubavu
A Sève
S Giaché
V Rzepecki
M Colin
C Boulard
G Thomas
A Cheret
C Goujard
Y Quertainmont
E Teicher
N Lerolle
S Jaureguiberry
R Colarino
O Deradji
A Castro
A Barrail-Tran
Y Yazdanpanah
R Landman
V Joly
J Ghosn
C Rioux
S Lariven
A Gervais
F Lescure
S Matheron
F Louni
Z Julia
S Le Gac
C Charpentier
D Descamps
G Peytavin
C Duvivier
C Aguilar
F Alby-Laurent
K Amazzough
G Benabdelmoumen
P Bossi
G Cessot
C Charlier
P Consigny
K Jidar
E Lafont
F Lanternier
J Leporrier
O Lortholary
C Louisin
J Lourenco
P Parize
B Pilmis
C Rouzaud
F Touam
M Valantin
R Tubiana
R Agher
S Seang
L Schneider
R Palich
C Blanc
C Katlama
Firouze Bani-Sadr - Université de Reims Champagne-Ardenne
J Berger
Y N’guyen
D Lambert
I Kmiec
M Hentzien
A Brunet
J Romaru
H Marty
V Brodard
C Arvieux
P Tattevin
M Revest
F Souala
M Baldeyrou
S Patrat-Delon
J Chapplain
F Benezit
M Dupont
M Poinot
A Maillard
C Pronier
F Lemaitre
C Morlat
M Poisson-Vannier
T Jovelin
J Sinteff
A Gagneux-Brunon
E Botelho-Nevers
A Frésard
V Ronat
F Lucht
David Rey - Hôpitaux Universitaires de Strasbourg
P Fischer
M Partisani
C Cheneau
M Priester
C Mélounou
C Bernard-Henry
E de Mautort
S Fafi-Kremer
Pierre Delobel
M Alvarez
N Biezunski
A Debard
C Delpierre
G Gaube
P Lansalot
L Lelièvre
M Marcel
G Martin-Blondel
M Piffaut
L Porte
K Saune
O Robineau
F Ajana
E Aïssi
I Alcaraz
E Alidjinou
V Baclet
L Bocket
A Boucher
M Digumber
Thomas Huleux - Centre Hospitalier de Tourcoing
B Lafon-Desmurs
A Meybeck
M Pradier
M Tetart
P Thill
N Viget
M Valette
Détails de publication: Clinical Infectious Diseases
Identifiants: 99152629909311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03341933