Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert; Carla Ibrahim-Verbaas; Denise Harold; Adam Naj; Rebecca Sims; Céline Bellenguez; Gyungah Jun; Anita Destefano; Joshua Bis; Gary Beecham; Benjamin Grenier-Boley; Giancarlo Russo; Tricia Thornton-Wells; Nicola Jones; Albert Smith; Vincent Chouraki; Charlene Thomas; M Arfan Ikram; Diana Zelenika; Badri Vardarajan; Yoichiro Kamatani; Chiao-Feng Lin; Amy Gerrish; Helena Schmidt; Brian Kunkle; Melanie Dunstan; Agustin Ruiz; Marie-Thérèse Bihoreau; Seung-Hoan Choi; Christiane Reitz; Florence Pasquier; Paul Hollingworth; Alfredo Ramirez; Olivier Hanon; Annette Fitzpatrick; Joseph Buxbaum; Dominique Campion; Paul Crane; Clinton Baldwin; Tim Becker; Vilmundur Gudnason; Carlos Cruchaga; David Craig; Najaf Amin; Claudine Berr; Oscar Lopez; Philip de Jager; Vincent Deramecourt; Janet Johnston; Denis Evans; Simon Lovestone; Luc Letenneur; Francisco Morón; David Rubinsztein; Gudny Eiriksdottir; Kristel Sleegers; Alison Goate; Nathalie Fiévet; Matthew Huentelman; Michael Gill; Kristelle Brown; M Ilyas Kamboh; Lina Keller; Pascale Barberger-Gateau; Bernadette Mcguinness; Eric Larson; Robert Green; Amanda Myers; Carole Dufouil; Stephen Todd; David Wallon; Seth Love; Ekaterina Rogaeva; John Gallacher; Peter St George-Hyslop; Jordi Clarimon; Alberto Lleo; Anthony Bayer; Debby Tsuang; Lei Yu; Magda Tsolaki; Paola Bossù; Gianfranco Spalletta; Petroula Proitsi; John Collinge; Sandro Sorbi; Florentino Sanchez-Garcia; Nick Fox; John Hardy; Maria Candida Deniz Naranjo; Paolo Bosco; Robert Clarke; Carol Brayne; Daniela Galimberti; Michelangelo Mancuso; Fiona Matthews; Susanne Moebus; Patrizia Mecocci; Maria del Zompo; Wolfgang Maier; Harald Hampel; Alberto Pilotto; Maria Bullido; Francesco Panza; Paolo Caffarra; Benedetta Nacmias; John Gilbert; Manuel Mayhaus; Lars Lannfelt; Hakon Hakonarson; Sabrina Pichler; Minerva Carrasquillo; Martin Ingelsson; Duane Beekly; Victoria Alvarez; Fanggeng Zou; Otto Valladares; Steven Younkin; Eliecer Coto; Kara Hamilton-Nelson; Wei Gu; Cristina Razquin; Pau Pastor; Ignacio Mateo; Michael Owen; Kelley Faber; Palmi Jonsson; Onofre Combarros; Michael O'Donovan; Laura Cantwell; Hilkka Soininen; Deborah Blacker; Simon Mead; Thomas Mosley; David Bennett; Tamara Harris; Laura Fratiglioni; Clive Holmes; Renee de Bruijn; Peter Passmore; Thomas Montine; Karolien Bettens; Jerome Rotter; Alexis Brice; Kevin Morgan; Tatiana Foroud; Walter Kukull; Didier Hannequin; John Powell; Michael Nalls; Karen Ritchie; Kathryn Lunetta; John Kauwe; Eric Boerwinkle; Matthias Riemenschneider; Mercè Boada; Mikko Hiltunen; Eden Martin; Reinhold Schmidt; Dan Rujescu; Li-San Wang; Jean-François Dartigues; Richard Mayeux; Christophe Tzourio; Albert Hofman; Markus Nöthen; Caroline Graff; Bruce Psaty; Lesley Jones; Jonathan Haines; Peter Holmans; Mark Lathrop; Margaret Pericak-Vance; Lenore Launer; Lindsay Farrer; Cornelia van Duijn; Christine van Broeckhoven; Valentina Moskvina; Sudha Seshadri; Julie Williams; Gerard Schellenberg; Philippe Amouyel

doi:10.1038/ng.2802

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert, Carla Ibrahim-Verbaas, Denise Harold, Adam Naj, Rebecca Sims, Céline Bellenguez, Gyungah Jun, Anita Destefano, Joshua Bis, Gary Beecham, …

Nature Genetics, Vol.45(12), pp.1452-1458

27/10/2013

DOI: https://doi.org/10.1038/ng.2802

PMCID: PMC3896259

PMID: 24162737

Résumé

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

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Titre: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Créateurs - sans rôle: Jean-Charles Lambert - Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
Carla Ibrahim-Verbaas - Université de Lille
Denise Harold - Cardiff University
Adam Naj - University of Pennsylvania
Rebecca Sims - Medical Research Council
Céline Bellenguez - Université de Lille
Gyungah Jun - Cardiff University
Anita Destefano - Université de Lille
Joshua Bis - University of Washington
Gary Beecham - Dr. John T. Macdonald Foundation
Benjamin Grenier-Boley - Institut Pasteur de Lille
Giancarlo Russo - University of Zurich
Tricia Thornton-Wells - Vanderbilt University
Nicola Jones - University of Zurich
Albert Smith - University of Iceland
Vincent Chouraki - Cardiff University
Charlene Thomas - University of Iceland
M Arfan Ikram - Université de Lille
Diana Zelenika - Medical Research Council
Badri Vardarajan - Netherlands Consortium for Healthy Ageing
Yoichiro Kamatani - Fondation Jean Dausset-CEPH
Chiao-Feng Lin
Amy Gerrish - Medical Research Council
Helena Schmidt - Medical University of Graz
Brian Kunkle - Cardiff University
Melanie Dunstan - Cardiff University
Agustin Ruiz - Fundació ACE
Marie-Thérèse Bihoreau - Centre National de Génotypage
Seung-Hoan Choi
Christiane Reitz - Columbia University
Florence Pasquier - Boston University
Paul Hollingworth - Cardiff University
Alfredo Ramirez
Olivier Hanon - Université Paris Cité
Annette Fitzpatrick - University of Washington
Joseph Buxbaum - Université Paris Cité
Dominique Campion - Université de Rouen Normandie
Paul Crane - University of Washington
Clinton Baldwin - Boston University
Tim Becker - University of Washington
Vilmundur Gudnason
Carlos Cruchaga - Washington University in St. Louis
David Craig - Queen's University Belfast
Najaf Amin - Washington University in St. Louis
Claudine Berr - Queen's University Belfast
Oscar Lopez
Philip de Jager - Harvard University
Vincent Deramecourt - Université de Lille
Janet Johnston - Harvard University
Denis Evans - Université de Lille
Simon Lovestone - King's College London
Luc Letenneur - Rush University Medical Center
Francisco Morón - King's College London
David Rubinsztein - Inserm
Gudny Eiriksdottir - Icelandic Heart Association
Kristel Sleegers - University of Cambridge
Alison Goate - Washington University in St. Louis
Nathalie Fiévet - VIB-UAntwerp Center for Molecular Neurology
Matthew Huentelman - Translational Genomics Research Institute
Michael Gill - Institut Pasteur de Lille
Kristelle Brown - Queen's Medical Centre
M Ilyas Kamboh - University of Pittsburgh
Lina Keller - Karolinska Institutet
Pascale Barberger-Gateau - University of Pittsburgh
Bernadette Mcguinness - Stockholm University
Eric Larson - University of Washington
Robert Green - Queen's University Belfast
Amanda Myers - University of Miami
Carole Dufouil - Harvard University
Stephen Todd - Queen's University Belfast
David Wallon - Inserm
Seth Love - Frenchay Hospital
Ekaterina Rogaeva - University of Toronto
John Gallacher - Cardiff University
Peter St George-Hyslop
Jordi Clarimon - University Hospital of Wales
Alberto Lleo - University of Cambridge
Anthony Bayer
Debby Tsuang - Biomedical Research Networking Center on Neurodegenerative Diseases
Lei Yu - Rush University Medical Center
Magda Tsolaki - Aristotle University of Thessaloniki
Paola Bossù - Rush University Medical Center
Gianfranco Spalletta - Fondazione Santa Lucia
Petroula Proitsi - Fondazione Santa Lucia
John Collinge - Fondazione Santa Lucia
Sandro Sorbi - King's College London
Florentino Sanchez-Garcia - University College London
Nick Fox - University of Florence
John Hardy - Hospital Universitario de Gran Canaria Doctor Negrín
Maria Candida Deniz Naranjo - UK Dementia Research Institute
Paolo Bosco - Oasi Maria SS
Robert Clarke - University of Oxford
Carol Brayne - Oasi Maria SS
Daniela Galimberti - University of Oxford
Michelangelo Mancuso - University of Cambridge
Fiona Matthews - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Susanne Moebus - Institut für Medizinische Informatik, Biometrie und Epidemiologie
Patrizia Mecocci - University of Perugia
Maria del Zompo - University of Cagliari
Wolfgang Maier - University of Perugia
Harald Hampel
Alberto Pilotto
Maria Bullido
Francesco Panza
Paolo Caffarra
Benedetta Nacmias
John Gilbert
Manuel Mayhaus
Lars Lannfelt
Hakon Hakonarson
Sabrina Pichler
Minerva Carrasquillo
Martin Ingelsson
Duane Beekly
Victoria Alvarez
Fanggeng Zou
Otto Valladares
Steven Younkin
Eliecer Coto
Kara Hamilton-Nelson
Wei Gu
Cristina Razquin
Pau Pastor
Ignacio Mateo
Michael Owen
Kelley Faber
Palmi Jonsson
Onofre Combarros
Michael O'Donovan
Laura Cantwell
Hilkka Soininen
Deborah Blacker
Simon Mead
Thomas Mosley
David Bennett
Tamara Harris
Laura Fratiglioni
Clive Holmes
Renee de Bruijn
Peter Passmore
Thomas Montine
Karolien Bettens
Jerome Rotter
Alexis Brice - Institut du Cerveau
Kevin Morgan
Tatiana Foroud
Walter Kukull
Didier Hannequin - Charmo University
John Powell
Michael Nalls
Karen Ritchie
Kathryn Lunetta
John Kauwe
Eric Boerwinkle
Matthias Riemenschneider
Mercè Boada
Mikko Hiltunen
Eden Martin
Reinhold Schmidt
Dan Rujescu
Li-San Wang
Jean-François Dartigues - Centre Hospitalier Universitaire de Bordeaux
Richard Mayeux
Christophe Tzourio - Neuroépidémiologie
Albert Hofman
Markus Nöthen
Caroline Graff
Bruce Psaty
Lesley Jones
Jonathan Haines
Peter Holmans
Mark Lathrop - Centre National de Génotypage
Margaret Pericak-Vance
Lenore Launer
Lindsay Farrer
Cornelia van Duijn
Christine van Broeckhoven
Valentina Moskvina
Sudha Seshadri
Julie Williams
Gerard Schellenberg
Philippe Amouyel - Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations
Détails de publication: Nature Genetics, Vol.45(12), pp.1452-1458
Identifiants: 99160952609311
Unité académique: Université de Montpellier
Langue: English
Type de ressource: Journal article
Champs locaux: cea-04697115