Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Josep Antó; Jean Bousquet; Mübeccel Akdis; Charles Auffray; Thomas Keil; Isabelle Momas; Dirkje S. Postma; Rudolf Valenta; Magnus Wickman; Anne Cambon-Thomsen; Tari Haahtela; Bart Lambrecht; Karin C. Lodrup Carlsen; Gerard H. Koppelman; Jordi Sunyer; Torsten Zuberbier; Isabella Annesi-Maesano; Albert Arno; Carsten Bindslev-Jensen; Giuseppe de Carlo; Francesco Forastiere; Joachim Heinrich; Marek Kowalski; Dieter Maier; Erik Melen; Henriette Smit; Marie Standl; John Wright; Anna Asarnoj; Marta Benet; Natalia Ballardini; Judith Garcia-Aymerich; Ulrike Gehring; Stefano Guerra; Cynthia Hohmann; Inger Kull; Christian Lupinek; Mariona Pinart; Ingebjorg Skrindo; Marit Westman; Delphine Smagghe; Cezmi Akdis; Niklas Andersson; Claus Bachert; Stephane Ballereau; Ferran Ballester; Xavier Basagaña; Anna Bedbrook; Anna Bergström; Andrea von Berg; Bert Brunekreef; Emilie Burte; Kai-Håkon Carlsen; Leda Chatzi; Jonathan Coquet; Mirela Curin; Pascal Demoly; Esben Eller; Maria Pia Fantini; Leena von Hertzen; Vergard Hovland; Bénédicte Jacquemin; Jocelyne Just; Theresa Keller; Renata Kiss; Manolis Kogevinas; Sibylle Koletzko; Susanne Lau; Irina Lehmann; Nicolas Lemonnier; Mika Mäkelä; Jordi Mestres; Peter Mowinckel; Rachel Nadif; Martijn C. Nawijn; Johan Pellet; Isabelle Pin; Daniela Porta; Fanny Rancière; Emmanuelle Rial-Sebbag; Yvan Saeys; Martijn Schuijs; Valérie Siroux; Christina Tischer; Mathies Torrent; Raphaëlle Varraso; Kalus Wenzel; Cheng-Jian Xu

doi:10.1016/j.jaci.2016.12.940

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Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

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Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Josep Antó, Jean Bousquet, Mübeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S. Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, …

Journal of Allergy and Clinical Immunology, Vol.139(2), pp.388 - 399

02/2017

DOI: https://doi.org/10.1016/j.jaci.2016.12.940

PMID: 28183433

Abstract

Asthma

allergy

atopic dermatitis

rhinitis

Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.

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Title: Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
Creators - without role: Josep Antó - Center for Research in Environmental Epidemiology
Jean Bousquet - Centre Hospitalier Universitaire de Montpellier
Mübeccel Akdis - University of Zurich
Charles Auffray - Centre National de la Recherche Scientifique
Thomas Keil - Charité - Universitätsmedizin Berlin
Isabelle Momas - Sorbonne Paris Cité
Dirkje S. Postma - University of Groningen
Rudolf Valenta - Medical University of Vienna
Magnus Wickman - Sachs' Children and Youth Hospital
Anne Cambon-Thomsen - Université Toulouse III - Paul Sabatier
Tari Haahtela - Helsinki University Hospital
Bart Lambrecht - Ghent University
Karin C. Lodrup Carlsen
Gerard H. Koppelman - University of Groningen
Jordi Sunyer - Center for Research in Environmental Epidemiology
Torsten Zuberbier - Charité - Universitätsmedizin Berlin
Isabella Annesi-Maesano - ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins
Albert Arno
Carsten Bindslev-Jensen - Odense University Hospital
Giuseppe de Carlo - European Federation of Allergy and Airways Diseases Patients Associations
Francesco Forastiere - Agenzia Regionale Parchi
Joachim Heinrich - Helmholtz Zentrum München
Marek Kowalski - Medical University of Lodz
Dieter Maier - Biomax Informatics
Erik Melen - Sachs' Children and Youth Hospital
Henriette Smit - Utrecht University
Marie Standl - Helmholtz Zentrum München
John Wright - Bradford Royal Infirmary
Anna Asarnoj - Karolinska University Hospital
Marta Benet - Center for Research in Environmental Epidemiology
Natalia Ballardini - King's College London
Judith Garcia-Aymerich - Pompeu Fabra University
Ulrike Gehring - Utrecht University
Stefano Guerra - Center for Research in Environmental Epidemiology
Cynthia Hohmann - Charité - Universitätsmedizin Berlin
Inger Kull - Sachs' Children and Youth Hospital
Christian Lupinek - Medical University of Vienna
Mariona Pinart - Center for Research in Environmental Epidemiology
Ingebjorg Skrindo
Marit Westman - Karolinska University Hospital
Delphine Smagghe - Inserm
Cezmi Akdis - University of Zurich
Niklas Andersson - Karolinska Institutet
Claus Bachert - Ghent University Hospital
Stephane Ballereau - Université Claude Bernard Lyon 1
Ferran Ballester - Universitat de València
Xavier Basagaña - Center for Research in Environmental Epidemiology
Anna Bedbrook - Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon
Anna Bergström - Karolinska Institutet
Andrea von Berg - Marien Hospital Wesel
Bert Brunekreef - Utrecht University
Emilie Burte - Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
Kai-Håkon Carlsen
Leda Chatzi - University of Crete
Jonathan Coquet - Ghent University
Mirela Curin - Medical University of Vienna
Pascal Demoly - Centre Hospitalier Universitaire de Montpellier
Esben Eller - Odense University Hospital
Maria Pia Fantini - University of Bologna
Leena von Hertzen - Helsinki University Hospital
Vergard Hovland - Oslo University Hospital
Bénédicte Jacquemin - Center for Research in Environmental Epidemiology
Jocelyne Just - Sorbonne Université
Theresa Keller - Charité - Universitätsmedizin Berlin
Renata Kiss - Medical University of Vienna
Manolis Kogevinas - Center for Research in Environmental Epidemiology
Sibylle Koletzko - Ludwig-Maximilians-Universität München
Susanne Lau - Charité - Universitätsmedizin Berlin
Irina Lehmann - Helmholtz Centre for Environmental Research
Nicolas Lemonnier - Institut pour l'avancée des biosciences
Mika Mäkelä - Helsinki University Hospital
Jordi Mestres - Chemo
Peter Mowinckel - Oslo University Hospital
Rachel Nadif - Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
Martijn C. Nawijn - University of Groningen
Johan Pellet - Université Claude Bernard Lyon 1
Isabelle Pin - Centre Hospitalier Universitaire de Grenoble
Daniela Porta - Agenzia Regionale Parchi
Fanny Rancière - Sorbonne Paris Cité
Emmanuelle Rial-Sebbag - Université Toulouse III - Paul Sabatier
Yvan Saeys - VIB-UGent Center for Inflammation Research
Martijn Schuijs - Ghent University
Valérie Siroux - Inserm
Christina Tischer - Helmholtz Zentrum München
Mathies Torrent - Parc de Salut
Raphaëlle Varraso - Vieillissement et Maladies Chroniques. Approches Epidémiologiques et de santé publique
Kalus Wenzel
Cheng-Jian Xu
Publication Details: Journal of Allergy and Clinical Immunology, Vol.139(2), pp.388 - 399
Identifiers: 9947577109311
Academic Unit: Université de Montpellier
Language: English
Resource Type: Journal article
Local Fields: hal-01784524