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Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication
Article de revue   Open Access   Avec comité de lecture

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

Romain Forey, Ana Poveda, Sushma Sharma, Antoine Barthe, Ismaël Padioleau, Claire Renard, Robin Lambert, Magdalena Skrzypczak, Krzysztof Ginalski, Armelle Lengronne, …
Molecular Cell, Vol.78(3), pp.396-410.e4
05/2020

Résumé

Highlights d The firing of early replication origins activates Mec1 ATR d The upregulation of dNTP pools prevents Mec1 ATR activation d Mec1 ATR triggers dNTP synthesis to complete S phase d Rad53 prevents fork collapse during dNTP shortage

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