Abstract
Porous silicon microcavity (PSiMc) structures were used as support material for specific sensing of matrix metal- loproteinases (MMPs). For lower concentrations of MMP-8, the structures were tested with two types of functionalization methods. Silanization of the oxidized porous silicon structures, followed by glutaraldehyde chemistry was found to give very inconsistent results. The use of biotinilated bovin serum albumin linked to the naked PSiMc was found to be an alternative method to attach the anti MMP-8 human antibody, previously modi- fied with streptavidin, which was further used to sense MMP-8.