Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Priyanka Choudhary; Giulietta S. Monasso; Ville Karhunen; Justiina Ronkainen; Giulia Mancano; Caitlin G. Howe; Zhongzheng Niu; Xuehuo Zeng; Weihua Guan; John Dou; Jason I. Feinberg; Charles Mordaunt; Giancarlo Pesce; Nour Baiz; Rossella Alfano; Dries S. Martens; Congrong Wang; Elena Isaevska; Elina Keikkala; Sanna Mustaniemi; Chris H.L. Thio; Eliza Fraszczyk; Elmar W. Tobi; Anne P. Starling; Marta Cosin-Tomas; José Urquiza; Stefan Röder; Thanh T. Hoang; Christian M Page; Dereje D. Jima; John S House; Rachel L. Maguire; Raffael Ott; Xenia Pawlow; Lea Sirignano; Lea Zillich; Anni Malmberg; Sebastian Rauschert; Phillip Melton; Tong Gong; Robert Karlsson; Ruby Fore; Wei Perng; Zachary M. Laubach; Darina Czamara; Gemma C Sharp; Carrie V. Breton; Enrique Schisterman; Edwina H Yeung; Sunni L. Mumford; M. Daniele Fallin; Janine M. Lasalle; Rebecca J. Schmidt; Kelly M. Bakulski; Isabella Annesi-Maesano; Barbara Heude; Tim S Nawrot; Michelle Plusquin; Akram Ghantous; Zdenko Herceg; Lorenza Nisticò; Marina Vafeiadi; Manolis Kogevinas; Marja Vääräsmäki; Eero Kajantie; Harold Snieder; Eva Corpeleijn; Regine P.M. Steegers-Theunissen; Ivana V. Yang; Dana Dabelea; Serena Fossati; Ana C. Zenclussen; Gunda Herberth; Maria Magnus; Siri E. Håberg; Stephanie J. London; Monica Cheng Munthe-Kaas; Susan K. Murphy; Cathrine Hoyo; Anette-G. Ziegler; Sandra Hummel; Stephanie H Witt; Fabian Streit; Josef Frank; Katri Räikkönen; Jari Lahti; Rae-Chi Huang; Catarina Almqvist; Marie-France Hivert; Vincent W.V. Jaddoe; Marjo-Riitta Järvelin; Marko Kantomaa; Janine Felix; Sylvain Sebert

doi:10.1038/s41380-023-02331-5

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Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

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Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Priyanka Choudhary, Giulietta S. Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G. Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, …

Molecular Psychiatry, Vol.29(2), pp.348-358

2024

DOI: https://doi.org/10.1038/s41380-023-02331-5

PMCID: PMC11116099

PMID: 38052982

Résumé

Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed to quantify the associations of MEA with offspring DNA methylation levels at birth, in childhood and in adolescence. Using 37 studies from high-income countries, we performed meta-analysis of epigenome-wide association studies (EWAS) to quantify the associations of completed years of MEA at the time of pregnancy with offspring DNA methylation levels at birth (n = 9 881), in childhood (n = 2 017), and adolescence (n = 2 740), adjusting for relevant covariates. MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence. We observed enrichment for findings from previous EWAS on maternal folate, vitamin-B12 concentrations, maternal smoking, and pre-pregnancy BMI. The associations were directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. Our findings form a bridge between socio-economic factors and biology and highlight potential pathways underlying effects of maternal education. The results broaden our understanding of bio-social associations linked to differential DNA methylation in multiple early stages of life. The data generated also offers an important resource to help a more precise understanding of the social determinants of health.

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Titre: Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Créateurs - sans rôle: Priyanka Choudhary - University of Oulu
Giulietta S. Monasso - Erasmus MC
Ville Karhunen - University of Oulu
Justiina Ronkainen - University of Oulu
Giulia Mancano - Medical Research Council
Caitlin G. Howe - Dartmouth College
Zhongzheng Niu - University of Southern California
Xuehuo Zeng - Glotech
Weihua Guan - University of Minnesota
John Dou - University of Michigan
Jason I. Feinberg - Johns Hopkins University
Charles Mordaunt - University of California, Davis
Giancarlo Pesce - Institut Pierre Louis d‘Épidémiologie et de Santé Publique
Nour Baiz - Université de Montpellier, Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Rossella Alfano - Hasselt University
Dries S. Martens - Hasselt University
Congrong Wang - Hasselt University
Elena Isaevska - University of Turin
Elina Keikkala - University of Oulu
Sanna Mustaniemi - University of Oulu
Chris H.L. Thio - University Medical Center Groningen
Eliza Fraszczyk - University of Groningen
Elmar W. Tobi - Erasmus MC
Anne P. Starling - Colorado School of Public Health
Marta Cosin-Tomas - Barcelona Biomedical Research Park
José Urquiza - Barcelona Biomedical Research Park
Stefan Röder - Helmholtz Centre for Environmental Research
Thanh T. Hoang - National Institutes of Health
Christian M Page - Oslo University Hospital
Dereje D. Jima - North Carolina State University
John S House - National Institute of Environmental Health Sciences
Rachel L. Maguire - North Carolina State University
Raffael Ott - Helmholtz Zentrum München
Xenia Pawlow - Helmholtz Zentrum München
Lea Sirignano - University Hospital Heidelberg
Lea Zillich - Central Institute of Mental Health
Anni Malmberg - University of Helsinki
Sebastian Rauschert - The Kids Research Institute Australia
Phillip Melton - University of Tasmania
Tong Gong - Karolinska Institutet
Robert Karlsson - Karolinska Institutet
Ruby Fore - Harvard Pilgrim Health Care
Wei Perng - University of Colorado Anschutz Medical Campus
Zachary M. Laubach - University of Colorado Boulder
Darina Czamara - Max Planck Institute of Psychiatry
Gemma C Sharp - Medical Research Council
Carrie V. Breton - University of Southern California
Enrique Schisterman - University of Pennsylvania
Edwina H Yeung - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Sunni L. Mumford - University of Pennsylvania
M. Daniele Fallin - Johns Hopkins University
Janine M. Lasalle - University of California, Davis
Rebecca J. Schmidt - University of California, Davis
Kelly M. Bakulski - University of Michigan
Isabella Annesi-Maesano - Université de Montpellier, Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Barbara Heude - Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Tim S Nawrot - Hasselt University
Michelle Plusquin - Hasselt University
Akram Ghantous - Centre international de recherche sur le cancer
Zdenko Herceg - Centre international de recherche sur le cancer
Lorenza Nisticò - Istituto Superiore di Sanità
Marina Vafeiadi - University of Crete
Manolis Kogevinas - Barcelona Institute for Global Health
Marja Vääräsmäki - Oulu University Hospital
Eero Kajantie - University of Oulu
Harold Snieder - University Medical Center Groningen
Eva Corpeleijn - University Medical Center Groningen
Regine P.M. Steegers-Theunissen - Erasmus MC
Ivana V. Yang - Colorado School of Public Health
Dana Dabelea - Colorado School of Public Health
Serena Fossati - Barcelona Biomedical Research Park
Ana C. Zenclussen - Helmholtz Centre for Environmental Research
Gunda Herberth - Helmholtz Centre for Environmental Research
Maria Magnus - Norwegian Institute of Public Health
Siri E. Håberg - Norwegian Institute of Public Health
Stephanie J. London - National Institute of Environmental Health Sciences
Monica Cheng Munthe-Kaas - Oslo University Hospital
Susan K. Murphy - Duke Medical Center
Cathrine Hoyo - North Carolina State University
Anette-G. Ziegler - German Center for Diabetes Research
Sandra Hummel - Helmholtz Zentrum München
Stephanie H Witt - University Hospital Heidelberg
Fabian Streit - Heidelberg University
Josef Frank - Heidelberg University
Katri Räikkönen - University of Helsinki
Jari Lahti - University of Helsinki
Rae-Chi Huang - The Kids Research Institute Australia
Catarina Almqvist - Karolinska Institutet
Marie-France Hivert - Harvard Medical School
Vincent W.V. Jaddoe - Erasmus MC
Marjo-Riitta Järvelin - University of Oulu
Marko Kantomaa - University of Oulu
Janine Felix - Erasmus MC
Sylvain Sebert - University of Oulu
Détails de publication: Molecular Psychiatry, Vol.29(2), pp.348-358
Note de subvention: This work received support from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733206 (LifeCycle), grant agreement no. 873749 (LongITools), and grant agreement no. 848158 (EarlyCause). The funding organisations were not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. The Supplementary File contains detail of the cohort specific acknowledgements and fundings.
Identifiants: 99161619409311
Unité académique: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Langue: English
Type de ressource: Journal article
Champs locaux: hal-04615214