Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Jean Bousquet; Ioana Agache; Hubert Blain; Marek Jutel; Maria Teresa Ventura; Margitta Worm; Stefano del Giacco; Athanasios Benetos; Beatrice Maria Bilo; Wienczyslawa Czarlewski; Amir Hamzah Abdul Latiff; Mona Al‐ahmad; Elizabeth Angier; Isabella Annesi‐maesano; Marina Atanaskovic‐markovic; Claus Bachert; Annick Barbaud; Anna Bedbrook; Kazi Bennoor; Elena Camelia Berghea; Carsten Bindslev‐jensen; Sergio Bonini; Sinthia Bosnic‐anticevich; Knut Brockow; Luisa Brussino; Paulo Camargos; G. Walter Canonica; Victoria Cardona; Pedro Carreiro‐martins; Ana Carriazo; Thomas Casale; Jean‐christoph Caubet; Lorenzo Cecchi; Antonio Cherubini; George Christoff; Derek Chu; Alvaro Cruz; Dejan Dokic; Yehia El‐gamal†; Motohiro Ebisawa; Bernadette Eberlein; John Farrell; Montserrat Fernandez‐rivas; Wytske Fokkens; Joao Fonseca; Yadong Gao; Gaëtan Gavazzi; Radoslaw Gawlik; Asli Gelincik; Bilun Gemicioğlu; Maia Gotua; Olivier Guérin; Tari Haahtela; Karin Hoffmann‐sommergruber; Hans Jürgen Hoffmann; Maja Hofmann; Martin Hrubisko; Maddalena Illario; Carla Irani; Zhanat Ispayeva; Juan Carlos Ivancevich; Kaja Julge; Igor Kaidashev; Musa Khaitov; Edward Knol; Helga Kraxner; Piotr Kuna; Violeta Kvedariene; Antti Lauerma; Lan Le; Vincent Le Moing; Michael Levin; Renaud Louis; Olga Lourenco; Vera Mahler; Finbarr Martin; Andrea Matucci; Branislava Milenkovic; Stéphanie Miot; Emma Montella; Mario Morais‐almeida; Charlotte Mortz; Joaquim Mullol; Leyla Namazova‐baranova; Hugo Neffen; Kristof Nekam; Marek Niedoszytko; Mikaëla Odemyr; Robyn O’hehir; Yoshitaka Okamoto; Markus Ollert; Oscar Palomares; Nikolaos Papadopoulos; Petr Panzner; Giovanni Passalacqua; Vincenzo Patella; Mirko Petrovic; Oliver Pfaar; Nhân Pham‐thi; Davor Plavec; Todor Popov; Marysia Recto; Frederico Regateiro; Jacques Reynes; Regina Roller‐winsberger; Yves Rolland; Antonino Romano; Carmen Rondon; Menachem Rottem; Philip Rouadi; Nathalie Salles; Boleslaw Samolinski; Alexandra Santos; Faradiba Sarquis; Joaquin Sastre; Jos M. G. A. Schols; Nicola Scichilone; Anna Sediva; Mohamed Shamji; Aziz Sheikh; Isabel Skypala; Sylwia Smolinska; Milena Sokolowska; Bernardo Sousa‐pinto; Milan Sova; Rafael Stelmach; Gunter Sturm; Charlotte Suppli Ulrik; Ana Maria Todo‐bom; Sanna Toppila‐salmi; Ioanna Tsiligianni; Maria Torres; Eva Untersmayr; Marilyn Urrutia Pereira; Arunas Valiulis; Joana Vitte; Alessandra Vultaggio; Dana Wallace; Jolanta Walusiak‐skorupa; De‐yun Wang; Susan Waserman; Arzu Yorgancioglu; Osman Yusuf; Mario Zernotti; Mihaela Zidarn; Tomas Chivato; Cezmi Akdis; Torsten Zuberbier; Ludger Klimek

doi:10.1111/all.14838

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Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Journal article

Open access

Peer reviewed

Management of anaphylaxis due to COVID‐19 vaccines in the elderly

Jean Bousquet, Ioana Agache, Hubert Blain, Marek Jutel, Maria Teresa Ventura, Margitta Worm, Stefano del Giacco, Athanasios Benetos, Beatrice Maria Bilo, Wienczyslawa Czarlewski, …

Allergy, Vol.76(10), pp.2952-2964

10/2021

DOI: https://doi.org/10.1111/all.14838

PMCID: PMC8251336

PMID: 33811358

Abstract

COVID -19 vaccines

Adrenaline

Anaphylaxis

Older

Aged

Covid-19

Covid-19 vaccines

Epinephrine

Humans

Male

SARS-CoV-2

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

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Title: Management of anaphylaxis due to COVID‐19 vaccines in the elderly
Creators - without role: Jean Bousquet - Humboldt-Universität zu Berlin
Ioana Agache - Transylvania University of Brașov
Hubert Blain - Centre Hospitalier Universitaire de Montpellier
Marek Jutel - Wroclaw Medical University
Maria Teresa Ventura - University of Bari Aldo Moro
Margitta Worm - Humboldt-Universität zu Berlin
Stefano del Giacco - University of Cagliari
Athanasios Benetos - Université de Lorraine
Beatrice Maria Bilo - Ospedali Riuniti di Ancona
Wienczyslawa Czarlewski - Medical Consulting Czarlewski
Amir Hamzah Abdul Latiff - Universiti Putra Malaysia
Mona Al‐ahmad - Kuwait University
Elizabeth Angier - University of Southampton
Isabella Annesi‐maesano - Université de Montpellier, Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Marina Atanaskovic‐markovic - University of Belgrade
Claus Bachert - Ghent University Hospital
Annick Barbaud - Sorbonne Université
Anna Bedbrook - Hospital Kuala Lumpur
Kazi Bennoor - National Institute of Cardiovascular Diseases
Elena Camelia Berghea - University of Medicine and Pharmacy “Carol Davila”
Carsten Bindslev‐jensen - Odense University Hospital
Sergio Bonini - Italian National Research Council
Sinthia Bosnic‐anticevich - Woolcock Institute of Medical Research
Knut Brockow - Technical University of Munich
Luisa Brussino - University of Turin
Paulo Camargos - Universidade Federal de Minas Gerais
G. Walter Canonica - IRCCS Humanitas Research Hospital
Victoria Cardona - Vall d'Hebron Hospital Universitari
Pedro Carreiro‐martins - Centro Hospitalar de Lisboa Central
Ana Carriazo - Ministry of Health
Thomas Casale - University of South Florida
Jean‐christoph Caubet - University Hospital of Geneva
Lorenzo Cecchi - Azienda Usl Toscana Centro
Antonio Cherubini - Istituto Nazionale di Riposo e Cura per Anziani
George Christoff - Medical University of Sofia
Derek Chu - McMaster University
Alvaro Cruz - Universidade Federal da Bahia
Dejan Dokic - Institute of Public Health of Republic of North Macedonia [Skopje]
Yehia El‐gamal† - Ain Shams University
Motohiro Ebisawa - National Sagamihara Hospital
Bernadette Eberlein - Technical University of Munich
John Farrell
Montserrat Fernandez‐rivas - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Wytske Fokkens - Academic Medical Center
Joao Fonseca - Universidade do Porto
Yadong Gao - Zhongnan Hospital of Wuhan University
Gaëtan Gavazzi - Université Grenoble Alpes
Radoslaw Gawlik - Silesian University of Medicine
Asli Gelincik - Istanbul University
Bilun Gemicioğlu - Istanbul University-Cerrahpaşa
Maia Gotua - AIDS and Clinical Immunology Research Center
Olivier Guérin - Centre Hospitalier Universitaire de Nice
Tari Haahtela - Helsinki University Hospital
Karin Hoffmann‐sommergruber - Medical University of Vienna
Hans Jürgen Hoffmann - Aarhus University
Maja Hofmann - Humboldt-Universität zu Berlin
Martin Hrubisko - Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety
Maddalena Illario - Federico II University Hospital
Carla Irani - Saint Joseph University
Zhanat Ispayeva - Kazakh National Medical University
Juan Carlos Ivancevich - Servicio de Alergia e ImmunologiaBuenos Aires
Kaja Julge - Tartu University Hospital
Igor Kaidashev - Ukrainina Medical Stomatological Academy [Poltava, Ukraine]
Musa Khaitov - Federal Medical-Biological Agency
Edward Knol - University Medical Center Utrecht
Helga Kraxner - Semmelweis University
Piotr Kuna - Medical University of Lodz
Violeta Kvedariene - Vilnius University
Antti Lauerma - University of Helsinki
Lan Le - Ho Chi Minh City Medicine and Pharmacy University
Vincent Le Moing - Université de Montpellier
Michael Levin - University of Cape Town
Renaud Louis - Centre Hospitalier Universitaire Sart Tilman
Olga Lourenco - University of Beira Interior
Vera Mahler - Paul Ehrlich Institut
Finbarr Martin - King's College London
Andrea Matucci - Azienda Ospedaliero-Universitaria Careggi
Branislava Milenkovic - University of Belgrade
Stéphanie Miot - Centre Hospitalier Universitaire de Montpellier
Emma Montella - Federico II University Hospital
Mario Morais‐almeida - CUF Porto Hospital
Charlotte Mortz
Joaquim Mullol - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Leyla Namazova‐baranova - Pirogov Russian National Research Medical University
Hugo Neffen - Centro Científico Tecnológico - Santa Fe
Kristof Nekam - Buda Health Center
Marek Niedoszytko - Gdańsk Medical University
Mikaëla Odemyr - European Federation of Allergy and Airways Diseases Patients Associations
Robyn O’hehir - Alfred Health
Yoshitaka Okamoto - Chiba University Hospital
Markus Ollert - Luxembourg Institute of Health
Oscar Palomares - Universidad Complutense de Madrid
Nikolaos Papadopoulos - National and Kapodistrian University of Athens
Petr Panzner - Charles University
Giovanni Passalacqua - University of Genoa
Vincenzo Patella
Mirko Petrovic - Ghent University
Oliver Pfaar - Philipps University of Marburg
Nhân Pham‐thi - École Polytechnique
Davor Plavec - Children's Hospital Srebrnjak
Todor Popov - University Hospital St. Ivan Rilski
Marysia Recto - Asian Hospital and Medical Center
Frederico Regateiro - Hospitais da Universidade de Coimbra
Jacques Reynes - Université de Montpellier
Regina Roller‐winsberger - Medical University of Graz
Yves Rolland - Inserm
Antonino Romano - Istituti di Ricovero e Cura a Carattere Scientifico
Carmen Rondon - Hospital Regional Universitario de Málaga
Menachem Rottem - Technion – Israel Institute of Technology
Philip Rouadi - Rafik Hariri University Hospital
Nathalie Salles - Société Française de Cardiologie
Boleslaw Samolinski
Alexandra Santos - Asthma UK
Faradiba Sarquis - Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória
Joaquin Sastre - Hospital Universitario Fundación Jiménez Díaz
Jos M. G. A. Schols
Nicola Scichilone - University of Palermo
Anna Sediva - University Hospital in Motol
Mohamed Shamji - Imperial College London
Aziz Sheikh - University of Edinburgh
Isabel Skypala - Royal Brompton & Harefield NHS Foundation Trust
Sylwia Smolinska - Wroclaw Medical University
Milena Sokolowska
Bernardo Sousa‐pinto - Centre for Health Technology and Services Research
Milan Sova - University Hospital Olomouc
Rafael Stelmach - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Gunter Sturm - Medical University of Graz
Charlotte Suppli Ulrik
Ana Maria Todo‐bom - Hospitais da Universidade de Coimbra
Sanna Toppila‐salmi - University of Helsinki
Ioanna Tsiligianni - University of Crete
Maria Torres
Eva Untersmayr - Medical University of Vienna
Marilyn Urrutia Pereira
Arunas Valiulis - Vilnius University
Joana Vitte - Institut de Recherche pour le Développement
Alessandra Vultaggio - Azienda Ospedaliero-Universitaria Careggi
Dana Wallace - Nova Southeastern University
Jolanta Walusiak‐skorupa - Nofer Institute of Occupational Medicine
De‐yun Wang - National University of Singapore
Susan Waserman - McMaster University
Arzu Yorgancioglu
Osman Yusuf
Mario Zernotti - National University of Villa María
Mihaela Zidarn - University Clinic of Pulmonary and Allergic Diseases Golnik
Tomas Chivato - Universidad San Pablo CEU
Cezmi Akdis - University of Zurich
Torsten Zuberbier - Humboldt-Universität zu Berlin
Ludger Klimek - Johannes Gutenberg University Mainz
Publication Details: Allergy, Vol.76(10), pp.2952-2964
Identifiers: 9935103009311
Academic Unit: Institut Desbrest d Epidemiologie et de Sante Publique - IDESP
Language: English
Resource Type: Journal article
Local Fields: hal-03437014