Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

Journal article

Li Xue, Xavier Rovira, Pauline Scholler, Han Zhao, Jianfeng Liu, Jean-Philippe Pin and Philippe Rondard

Nature Chemical Biology, Vol.11(2), pp.134--40

02/2015

Abstract

Humans

Animals

HEK293 Cells

Protein Binding

Models

Molecular

Rats

Ligands

Transfection

Cercopithecus aethiops

COS Cells

Transcriptional Activation

Mutagenesis

Site-Directed

*Protein Multimerization

Alanine/genetics

Cysteine/genetics

Protein Structure

Tertiary

Protein Subunits

Receptor

Metabotropic Glutamate 5/agonists/chemistry/genetics

Receptors

GABA-B/chemistry/genetics/metabolism

Metabotropic Glutamate/agonists/*chemistry/genetics

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Title: Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer
Creators - without role: Li Xue - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Xavier Rovira - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Pauline Scholler - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Han Zhao - Huazhong University of Science and Technology
Jianfeng Liu - Huazhong University of Science and Technology
Jean-Philippe Pin - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Philippe Rondard - Université de Montpellier, Institut de Génomique Fonctionnelle - IGF
Publication Details: Nature Chemical Biology, Vol.11(2), pp.134--40
Identifiers: 9937091709311
Academic Unit: Institut de Génomique Fonctionnelle - IGF
Language: English
Resource Type: Journal article
Local Fields: hal-01943326