MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Michael G. Constantinides; Verena M. Link; Samira Tamoutounour; Andrea C. Wong; P. Juliana Perez-Chaparro; Seong-Ji Han; Y. Erin Chen; Kelin Li; Sepideh Farhat; Antonin Weckel; Siddharth R. Krishnamurthy; Ivan Vujkovic-Cvijin; Jonathan L. Linehan; Nicolas Bouladoux; E. Dean Merrill; Sobhan Roy; Daniel J. Cua; Erin J. Adams; Avinash Bhandoola; Tiffany C. Scharschmidt; Jeffrey Aube; Michael A. Fischbach; Yasmine Belkaid

doi:10.1126/science.aax6624

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MAIT cells are imprinted by the microbiota in early life and promote tissue repair

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MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Michael G. Constantinides, Verena M. Link, Samira Tamoutounour, Andrea C. Wong, P. Juliana Perez-Chaparro, Seong-Ji Han, Y. Erin Chen, Kelin Li, Sepideh Farhat, Antonin Weckel, …

Science (American Association for the Advancement of Science), Vol.366(6464), pp.445-445

25/10/2019

DOI: https://doi.org/10.1126/science.aax6624

PMID: 31649166

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

How early-life colonization and subsequent exposure to the microbiota affect long-term tissue immunity remains poorly understood. Here, we show that the development of mucosal-associated invariant T (MAIT) cells relies on a specific temporal window, after which MAIT cell development is permanently impaired. This imprinting depends on early-life exposure to defined microbes that synthesize riboflavin-derived antigens. In adults, cutaneous MAIT cells are a dominant population of interleukin-17A (IL-17A)-producing lymphocytes, which display a distinct transcriptional signature and can subsequently respond to skin commensals in an IL-1-, IL-18-, and antigen-dependent manner. Consequently, local activation of cutaneous MAIT cells promotes wound healing. Together, our work uncovers a privileged interaction between defined members of the microbiota and MAIT cells, which sequentially controls both tissue-imprinting and subsequent responses to injury.

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Titre: MAIT cells are imprinted by the microbiota in early life and promote tissue repair
Créateurs - sans rôle: Michael G. Constantinides - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Verena M. Link - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Samira Tamoutounour - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Andrea C. Wong - Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA
P. Juliana Perez-Chaparro - NIAID, NIAID Microbiome Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Seong-Ji Han - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Y. Erin Chen - Stanford Univ, Dept Bioengn & ChEM H, Stanford, CA 94305 USA
Kelin Li - Univ North Carolina, UNC Eshelman Sch Pharm, Div Chem Biol & Med Chem, Chapel Hill, NC 27599 USA
Sepideh Farhat - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Antonin Weckel - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Siddharth R. Krishnamurthy - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Ivan Vujkovic-Cvijin - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Jonathan L. Linehan - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Nicolas Bouladoux - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
E. Dean Merrill - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Sobhan Roy - Univ Chicago, Dept Biochem & Mol Biol, 920 E 58Th St, Chicago, IL 60637 USA
Daniel J. Cua - Merck & Co Inc, Merck Res Labs, Palo Alto, CA 94304 USA
Erin J. Adams - University of Chicago
Avinash Bhandoola - NCI, Lab Genome Integr, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
Tiffany C. Scharschmidt - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Jeffrey Aube - Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
Michael A. Fischbach - Stanford Univ, Dept Bioengn & ChEM H, Stanford, CA 94305 USA
Yasmine Belkaid - NIAID, Metaorganism Immun Sect, Lab Immune Syst Biol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA
Détails de publication: Science (American Association for the Advancement of Science), Vol.366(6464), pp.445-445
Éditeur: Amer Assoc Advancement Science
Nombre de pages: 34
Note de subvention: Chan Zuckerberg Biohub; Chan Zuckerberg Initiative (CZI) HHMI-Simons Faculty Scholars Program ZIAAI001132; ZIAAI001115 / National Institute of Allergy and Infectious Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) ZIA-AI001115; ZIA-AI001132 / Intramural Research Program of NIAID, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U19-AI111143; R01-DK110174; DP1-DK113598; DP2-AI144968 / NIH Extramural Research Program; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ARC Foundation; Australian Research Council; University of Queensland; Australian National University Howard Hughes Medical Institute (HHMI) Hanna H. Gray Fellows Program European Molecular Biology Organization (EMBO) Long-Term Fellowship Program; European Molecular Biology Organization (EMBO) National Institute of General Medical Sciences (NIGMS) Postdoctoral Research Associate Training (PRAT) Program Cancer Research Institute Irvington Postdoctoral Fellowship Program
Identifiants: 99155738309311
Unité académique: Cell souches plasticité cellul régénérat tissulaire immuno des maladies inflamm - IRMB
Langue: English
Type de ressource: Journal article