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Lymphotoxin alpha stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts
Journal article   Peer reviewed

Lymphotoxin alpha stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts

F. Calmon-Hamaty, B. Combe, M. Hahne and J. Morel
Cytokine, Vol.53(2), pp.207--14
2011
DOI: https://doi.org/10.1016/j.cyto.2010.10.010

Abstract

Arthritis Type II/metabolism Synovial Fluid/*cytology/drug effects p38 Mitogen-Activated Protein Kinases/metabolism Type I/metabolism Receptors Tumor Necrosis Factor Tumor Necrosis Factor Receptors Rheumatoid/*pathology Cell Nucleus/drug effects/metabolism Cell Proliferation/drug effects Cytokines/*secretion Enzyme Activation/drug effects Extracellular Signal-Regulated MAP Kinases/metabolism Fibroblasts/drug effects/enzymology/pathology/*secretion Humans Immunoglobulin G/pharmacology Inflammation Mediators/*metabolism Lymphotoxin-alpha/*pharmacology Matrix Metalloproteinase 3/secretion NF-kappa B/metabolism Protein Kinase Inhibitors/pharmacology Protein Transport/drug effects Proto-Oncogene Proteins c-akt/metabolism Receptors Member 14/metabolism Receptors
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