Low-level viral loads and virological failure in the integrase strand transfer era

Lise Cuzin; Philippe Flandre; Clotilde Allavena; Romain Palich; Claudine Duvivier; Agathe Becker; Hélène Laroche; Pascal Pugliese; André Cabie; C Chirouze; O Babre; K Bouiller; F Bozon; A Brunel; E Chevalier; L Hustache-Mathieu; J Lagoutte; Q Lepiller; S Marty-Quinternet; P Muret; B Rosolen; N Tissot; S Jaffuel; C Jacomet; C Aumeran; O Baud; A Brebion; V Corbin; E Goncalvez; C Henquell; H Laurichesse; O Lesens; D Mazzocolin; A Mirand; N Mrozek; C Theis; M Vidal; I Lamaury; F Bissuel; F Boulard; E Curlier; I Fabre; E Halley; C Herrmann-Storck; C Le Guillou; S Markowicz; M Marquet; R Ouissa; M Receveur; J Reltien; P Roger; B Tressieres; D Merrien; O Bollangier; D Boucher; T Guimard; L Laine; S Leautez; M Morrier; P Perré; P Point; J Faucher; A Cypierre; S Ducroix-Roubertou; H Durox; C Genet-Villeger; J Pascual; P Pinet; S Rogez; J Woillard; L Cotte; F Ader; D Alfaiate; A Boibieux; C Brochier; F Brunel-Dalmas; O Cannesson; P Chiarello; C Chidiac; A Conrad; S Degroodt; T Ferry; M Godinot; V Icard; J Livrozet; D Makhloufi; T Perpoint; M Perry; C Pouderoux; S Roux; M Trabaud; C Triffault-Fillit; F Valour; I Ravaux; A Ménard; S Aherfi; S Amrane; A Belkhir; P Colson; C Dhiver; M Martin-Degioanni; L Meddeb; M Mokhtari; A Motte; H Tissot-Dupont; C Toméi; I Poizot-Martin; S Brégigeon; M Ducassou; S Galie; A Ivanova; I Jaquet; V Obry-Roguet; M Orticoni; E Ressiot; A Ritleng; T Rojas-Rojas; O Zaegel-Faucher; S Abel; J Bavay; B Bigeard; O Cabras; R Dupin de Majoubert; L Fagour; K Guitteaud; M Lehoux; C Montagnac; S Pierre-François; K Rome; J Turmel; J Reynes; N Atoui; M Bistoquet; E Delaporte; V Le Moing; J Lejeune; A Makinson; N Meftah; C Merle de Boever; B Montes; A Montoya Ferrer; E Tuaillon; B Lefèvre; M André; G Baronnet; S Bevilacqua; L Boyer; M Bouillon; A Charmillon; M Delestan; E Frentiu; F Goehringer; S Hénard; E Jeanmaire; C Rabaud; A Radjabaly-Mandjee; F Raffi; E André-Garnier; A Asquier-Khati; E Billaud; C Biron; B Bonnet; S Bouchez; D Boutoille; C Brunet-Cartier; M Cavellec; C Deschanvres; V Ferré; B Gaborit; A Grégoire; M Grégoire; T Jovelin; M Lefebvre; R Lecomte; R Mahot; P Morineau; E Paredes; V Reliquet; S Sécher; A Soria; S Bréaud; M Buscot; M Carles; D Chirio; E Cua; P Dellamonica; E Demonchy; A de Monte; J Durant; S Ferrando; R Garraffo; C Michelangeli; A Naqvi; I Perbost; C Pradier; B Prouvost-Keller; K Risso; I Touitou; A Viot; S Wehrlen-Pugliese; L Hocqueloux; C Gubavu; V Legros; F Peira; T Prazuck; V Rzepecki; A Sève; A Cheret; A Barrail-Tran; A Castro; R Colarino; C Goujard; S Jaureguiberry; Y Quertainmont; E Teicher; V Joly; C Charpentier; D Descamps; M Digumber; A Gervais; J Ghosn; Z Julia; R Landman; S Lariven; S Le Gac; F Louni; G Peytavin; C Rioux; Y Yazdanpanah; K Amazzough; G Benabdelmoumen; P Bossi; G Cessot; C Charlier; P Consigny; E Gomes-Pires; K Jidar; E Lafont; F Lanternier; O Lortholary; C Louisin; J Lourenco; C Melenotte; P Parize; A Pouvaret; C Rouzaud; A Serris; F Touam; C Katlama; R Agher; C Blanc; Y Dudoit; N Hamani; N Qatib; I Qzaibri; L Lenclume; L Schneider; S Seang; R Tubiana; M Valantin; F Bani-Sadr; M Bermejo; J Berger; S Demotier; M Hentzien; G Julien; I Kmiec; D Lambert; H Marty; Y N’guyen; J Romaru; C Arvieux; M Baldeyrou; F Benezit; J Chapplain; M Dupont; J Duthé; A Lebot; F Lemaitre; A Maillard; C Morlat; S Patrat-Delon; M Poisson-Vannier; C Pronier; M Revest; J Sinteff; F Souala; P Tattevin; A Gagneux-Brunon; E Botelho-Nevers; A Frésard; F Lucht; V Ronat; D Rey; C Cheneau; C Bernard-Henry; E de Mautort; S Fafi-Kremer; P Fischer; P Gantner; C Mélounou; M Partisani; P Delobel; M Alvarez; N Biezunski; A Debard; C Delpierre; C Garnier; G Gaube; L Lelièvre; M Marcel; G Martin-Blondel; M Piffaut; L Porte; K Saune; O Robineau; E Aïssi; F Ajana; I Alcaraz; E Alidjinou; V Baclet; L Bocket; A Boucher; V Derdour; M Gilbert; T Huleux; B Lafon-Desmurs; A Meybeck; M Pradier; M Tetart; P Thill; M Valette; N Viget; G Corvaisier

doi:10.1093/jac/dkad056

Article de revue

Low-level viral loads and virological failure in the integrase strand transfer era

Lise Cuzin, Philippe Flandre, Clotilde Allavena, Romain Palich, Claudine Duvivier, Agathe Becker, Hélène Laroche, Pascal Pugliese, André Cabie, C Chirouze, …

Journal of Antimicrobial Chemotherapy, Vol.78(4), pp.1111-1116

03/04/2023

DOI: https://doi.org/10.1093/jac/dkad056

PMID: 36879512

Résumé

Anti-HIV Agents* / therapeutic use

HIV Infections*

Humans

Integrases

Proportional Hazards Models

Treatment Failure

Viral Load

Objectives: To analyse the occurrence of virological failure (VF) in patients starting ART with an integrase strand transfer inhibitor (INSTI)-based regimen in recent years, in relation with previous episodes of low-level viral load (LLVL).Patients and methods: Patients starting a first ART between 1 January 2015 and 31 December 2020 based on two NRTIs and one INSTI were included if after virological control (two measures of VL < 50 copies/mL) they had a minimum of two additional VL measurements. Cox models adjusted for sex, age, acquisition group, hepatitis B or C coinfection, place of birth, year of ART initiation, CD4+ T cells and VL at ART initiation, duration of known HIV infection and of ART regimen were used to assess the association between the time to VF and the occurrence of LLVL. ART regimen was evaluated as time-varying covariate.Results: LLVL was described in 13.7% and VF in 11% of the 3302 patients. LLVL was associated with VF [adjusted HR (aHR) 1.76, 95% CI 1.28-2.41], as well as age (aHR 0.97/year, 95% CI 0.96-0.98), CD4+ T cell count at ART initiation (aHR 0.93, 95% CI 0.87-0.98), heterosexual transmission (aHR 1.76, 95% CI 1.30-2.37) and being born abroad (aHR 1.50, 95% CI 1.17-1.93).Conclusions: LLVL was related to VF. Even in the absence of subsequent failure, LLV episodes have a cost. Thus any VL value above 50 copies/mL should lead to enhanced adherence counselling.

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Détails

Titre: Low-level viral loads and virological failure in the integrase strand transfer era
Créateurs - sans rôle: Lise Cuzin - Centre Hospitalier Universitaire de Martinique
Philippe Flandre - Inserm
Clotilde Allavena - Centre d'Investigation Clinique de Nantes
Romain Palich - Assistance Publique – Hôpitaux de Paris
Claudine Duvivier - Institut Cochin
Agathe Becker - Hospices Civils de Lyon
Hélène Laroche - Hôpital Sainte-Marguerite
Pascal Pugliese - Centre Hospitalier Universitaire de Nice
André Cabie - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
C Chirouze
O Babre
K Bouiller
F Bozon
A Brunel
E Chevalier
L Hustache-Mathieu
J Lagoutte
Q Lepiller
S Marty-Quinternet
P Muret
B Rosolen
N Tissot
S Jaffuel
C Jacomet
C Aumeran - Université Clermont Auvergne
O Baud
A Brebion
V Corbin
E Goncalvez
C Henquell
H Laurichesse
O Lesens
D Mazzocolin
A Mirand
N Mrozek
C Theis
M Vidal
I Lamaury
F Bissuel
F Boulard
E Curlier
I Fabre
E Halley
C Herrmann-Storck
C Le Guillou
S Markowicz
M Marquet
R Ouissa
M Receveur
J Reltien
P Roger
B Tressieres
D Merrien
O Bollangier
D Boucher
T Guimard
L Laine
S Leautez
M Morrier
P Perré
P Point
J Faucher
A Cypierre
S Ducroix-Roubertou
H Durox
C Genet-Villeger
J Pascual
P Pinet
S Rogez
J Woillard
L Cotte
F Ader
D Alfaiate
Agathe Becker - Hospices Civils de Lyon
A Boibieux - Hospices Civils de Lyon
C Brochier
F Brunel-Dalmas
O Cannesson
P Chiarello
C Chidiac
A Conrad
S Degroodt
T Ferry
M Godinot
V Icard
J Livrozet
D Makhloufi
T Perpoint
M Perry
C Pouderoux
S Roux
M Trabaud
C Triffault-Fillit
F Valour
I Ravaux
A Ménard
S Aherfi
S Amrane
A Belkhir
P Colson
C Dhiver
M Martin-Degioanni
L Meddeb
M Mokhtari
A Motte
H Tissot-Dupont
C Toméi
I Poizot-Martin
S Brégigeon
M Ducassou
S Galie
A Ivanova
I Jaquet
Hélène Laroche - Hôpital Sainte-Marguerite
V Obry-Roguet
M Orticoni
E Ressiot
A Ritleng
T Rojas-Rojas
O Zaegel-Faucher
André Cabie - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
S Abel - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
J Bavay
B Bigeard
O Cabras - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Lise Cuzin - Centre Hospitalier Universitaire de Martinique
R Dupin de Majoubert
L Fagour - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
K Guitteaud
M Lehoux
C Montagnac
S Pierre-François
K Rome
J Turmel
J Reynes
N Atoui
M Bistoquet
E Delaporte
V Le Moing
J Lejeune
A Makinson
N Meftah
C Merle de Boever
B Montes
A Montoya Ferrer - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
E Tuaillon - Université de Montpellier, Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
B Lefèvre
M André
G Baronnet
S Bevilacqua
L Boyer
M Bouillon
A Charmillon
M Delestan
E Frentiu
F Goehringer
S Hénard
E Jeanmaire
C Rabaud
A Radjabaly-Mandjee
F Raffi
Clotilde Allavena - Centre d'Investigation Clinique de Nantes
E André-Garnier
A Asquier-Khati
E Billaud
C Biron
B Bonnet
S Bouchez
D Boutoille
C Brunet-Cartier
M Cavellec
C Deschanvres
V Ferré
B Gaborit
A Grégoire
M Grégoire
T Jovelin
M Lefebvre
R Lecomte
R Mahot
P Morineau
E Paredes
V Reliquet
E André-Garnier
S Sécher
A Soria
Pascal Pugliese - Centre Hospitalier Universitaire de Nice
S Bréaud
M Buscot
M Carles
D Chirio
E Cua
P Dellamonica
E Demonchy
A de Monte
J Durant
S Ferrando
R Garraffo
C Michelangeli
A Naqvi
I Perbost
C Pradier
B Prouvost-Keller
K Risso
I Touitou
A Viot
S Wehrlen-Pugliese
L Hocqueloux
C Gubavu
V Legros
F Peira
T Prazuck
V Rzepecki
A Sève
A Cheret
A Barrail-Tran
A Castro
R Colarino
C Goujard
S Jaureguiberry
Y Quertainmont
E Teicher
V Joly
C Charpentier
D Descamps
M Digumber
A Gervais
J Ghosn
Z Julia
R Landman
S Lariven
S Le Gac
F Louni
G Peytavin
C Rioux
Y Yazdanpanah
Claudine Duvivier - Institut Cochin
K Amazzough
G Benabdelmoumen
P Bossi
G Cessot
C Charlier
P Consigny
E Gomes-Pires
K Jidar
E Lafont
F Lanternier
O Lortholary
C Louisin
J Lourenco
C Melenotte
P Parize
A Pouvaret
C Rouzaud
A Serris
F Touam
C Katlama
R Agher
C Blanc
Y Dudoit
N Hamani
N Qatib
I Qzaibri
L Lenclume
Romain Palich - Assistance Publique – Hôpitaux de Paris
L Schneider
S Seang
R Tubiana
M Valantin
F Bani-Sadr
M Bermejo
J Berger
S Demotier
M Hentzien
G Julien
I Kmiec
D Lambert
H Marty
Y N’guyen
J Romaru
C Arvieux
M Baldeyrou
F Benezit
J Chapplain
M Dupont
J Duthé
T Jovelin
A Lebot
F Lemaitre
A Maillard
C Morlat
S Patrat-Delon
M Poisson-Vannier
C Pronier
M Revest
J Sinteff
F Souala
P Tattevin
A Gagneux-Brunon
E Botelho-Nevers
A Frésard
F Lucht
V Ronat
D Rey
C Cheneau
C Bernard-Henry
E de Mautort
S Fafi-Kremer
P Fischer
P Gantner
C Mélounou
M Partisani
P Delobel
M Alvarez
N Biezunski
A Debard
C Delpierre
C Garnier
G Gaube
L Lelièvre
M Marcel
G Martin-Blondel
M Piffaut
L Porte
K Saune
O Robineau
E Aïssi
F Ajana
I Alcaraz
E Alidjinou
V Baclet
L Bocket
A Boucher
V Derdour
M Gilbert
T Huleux
B Lafon-Desmurs
A Meybeck
M Pradier
M Tetart
P Thill
M Valette
N Viget
G Corvaisier
Détails de publication: Journal of Antimicrobial Chemotherapy, Vol.78(4), pp.1111-1116
Identifiants: 99150309809311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article
Champs locaux: hal-04028835