Résumé
Combinatorial chemists need building block libraries where molecular diversity is taken into account. For this purpose, we describe the synthesis of a library of 2-alkyl and 2-alkoxypropanediamines for which a large scale of lipophilicity is investigated.
Library of 1,3-propanediamines is described: 1,3-diaminopropan-2-ol, correctly N-protected to avoid oxazolidinone formation, leads to 2-alkoxypropanediamines and malonic synthesis leads to 2-alkylpropanediamines.