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Linkage Mapping of the [Pro 2 ]Somatostatin-14 Gene in Zebrafish: Evolutionary Perspectives
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Linkage Mapping of the [Pro 2 ]Somatostatin-14 Gene in Zebrafish: Evolutionary Perspectives

Hervé Tostivint, Lucille Joly, Isabelle Lihrmann, J Michael Conlon, Marc Ekker et Hubert Vaudry
Annals of the New York Academy of Sciences, Vol.1040(1), pp.486-489
04/2005
PMID: 15891097

Résumé

Animals Biochemistry, Molecular Biology Cellular Biology Chromosome Mapping Evolution, Molecular Humans Life Sciences Somatostatin Subcellular Processes Zebrafish Zebrafish Proteins
Radiation hybrid mapping assigned the zebrafish [Pro(2)]somatostatin-14 (also termed somatostatin 2; SS2) gene to linkage group 23 of the zebrafish genome, close to the marker nadl1.2. Comparative genomic analysis revealed conserved syntenies of the SS2 gene locus with part of the human 1p36 region, where the cortistatin gene is located. This observation strongly suggests that the SS2 gene in nonmammalian species and the cortistatin gene in mammals are orthologous.

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