LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky; Geneviève Almouzni; Stanislaw A Gorski; Stein Aerts; Ido Amit; Michela G Bertero; Christoph Bock; Annelien L Bredenoord; Giacomo Cavalli; Susanna Chiocca; Hans Clevers; Bart de Strooper; Angelika Eggert; Jan Ellenberg; Xosé M Fernández; Marek Figlerowicz; Susan M Gasser; Norbert Hubner; Jørgen Kjems; Jürgen A Knoblich; Grietje Krabbe; Peter Lichter; Sten Linnarsson; Jean-Christophe Marine; John C Marioni; Marc A Marti-Renom; Mihai G Netea; Dörthe Nickel; Marcelo Nollmann; Halina R Novak; Helen Parkinson; Stefano Piccolo; Inês Pinheiro; Ana Pombo; Christian Popp; Wolf Reik; Sergio Roman-Roman; Philip Rosenstiel; Joachim L Schultze; Oliver Stegle; Amos Tanay; Giuseppe Testa; Dimitris Thanos; Fabian J Theis; Maria-Elena Torres-Padilla; Alfonso Valencia; Céline Vallot; Alexander van Oudenaarden; Marie Vidal; Thierry Voet; Lavinia Alberi; Stephanie Alexander; Theodore Alexandrov; Ernest Arenas; Claudia Bagni; Robert Balderas; Andrea Bandelli; Burkhard Becher; Matthias Becker; Niko Beerenwinkel; Monsef Benkirame; Marc Beyer; Wendy Bickmore; Erik E a L Biessen; Niklas Blomberg; Ingmar Blumcke; Bernd Bodenmiller; Barbara Borroni; Dimitrios T Boumpas; Thomas Bourgeron; Sarion Bowers; Dries Braeken; Catherine Brooksbank; Nils Brose; Hilgo Bruining; Jo Bury; Nicolo Caporale; Giorgio Cattoretti; Nadia Chabane; Hervé Chneiweiss; Stuart A Cook; Paolo Curatolo; Marien I de Jonge; Bart Deplancke; Peter de Witte; Stefanie Dimmeler; Bogdan Draganski; Anna Drews; Costica Dumbrava; Stefan Engelhardt; Thomas Gasser; Evangelos J Giamarellos-Bourboulis; Caroline Graff; Dominic Grün; Ivo Gut; Oskar Hansson; David C Henshall; Anna Herland; Peter Heutink; Stephane R B Heymans; Holger Heyn; Meritxell Huch; Inge Huitinga; Paulina Jackowiak; Karin R Jongsma; Laurent Journot; Jan Philipp Junker; Shauna Katz; Jeanne Kehren; Stefan Kempa; Paulus Kirchhof; Christine Klein; Natalia Koralewska; Jan O Korbel; Malte Kühnemund; Angus I Lamond; Elsa Lauwers; Isabelle Le Ber; Ville Leinonen; Alejandro Lopez Tobon; Emma Lundberg; Astrid Lunkes; Henrike Maatz; Matthias Mann; Luca Marelli; Vera Matser; Paul M Matthews; Fatima Mechta-Grigoriou; Radhika Menon; Anne F Nielsen; Massimiliano Pagani; R Jeroen Pasterkamp; Asla Pitkänen; Valentin Popescu; Cyril Pottier; Alain Puisieux; Rosa Rademakers; Dory Reiling; Orly Reiner; Daniel Remondini; Craig Ritchie; Jonathan D Rohrer; Antoine-Emmanuel Saliba; Raquel Sanchez-Valle; Amedeo Santosuosso; Arnold Sauter; Richard A Scheltema; Philip Scheltens; Herbert B Schiller; Anja Schneider; Philip Seibler; Kelly Sheehan-Rooney; David Shields; Kristel Sleegers; August B Smit; Kenneth G C Smith; Ilse Smolders; Matthis Synofzik; Wai Long Tam; Sarah Teichmann; Maria Thom; Margherita Y Turco; Heleen M M van Beusekom; Rik Vandenberghe; Silvie van den Hoecke; Ibo van de Poel; Andre van der Ven; Julie van der Zee; Jan van Lunzen; Geert van Minnebruggen; Wim van Paesschen; John van Swieten; Remko van Vught; Matthijs Verhage; Patrik Verstreken; Carlo Emanuele Villa; Jörg Vogel; Christof von Kalle; Jörn Walter; Sarah Weckhuysen; Wilko Weichert; Louisa Wood; Anette-Gabriele Ziegler; Frauke Zipp; Monsef Benkirane; Wendy A. Bickmore; Erik E. A. L. Biessen; Dimitrios T. Boumpas; Stuart A. Cook; Marien I. De Jonge; Bart De Strooper; Peter De Witte; Evangelos J. Giamarellos-Bourboulis; Ivo G. Gut; David C. Henshall; Stephane R. B. Heymans; Karin R. Jongsma; Jan O. Korbel; Angus I. Lamond; Alejandro López-Tobón; Paul M. Matthews; Anne F. Nielsen; R. Jeroen Pasterkamp; Jonathan D. Rohrer; Richard A. Scheltema; Herbert B. Schiller; David J. Shields; August B. Smit; Kenneth G. C. Smith; Sarah A. Teichmann; Margherita Y. Turco; Heleen M. M. Van Beusekom; Silvie van Den Hoecke; Ibo van De Poel; Andre van Der Ven; Julie van Der Zee; Jan Van Lunzen; Geert Van Minnebruggen; Alexander Van Oudenaarden; Wim Van Paesschen; John C. Van Swieten; Remko Van Vught; Christof Von Kalle

doi:10.1038/s41586-020-2715-9

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LifeTime and improving European healthcare through cell-based interceptive medicine

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LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky, Geneviève Almouzni, Stanislaw A Gorski, Stein Aerts, Ido Amit, Michela G Bertero, Christoph Bock, Annelien L Bredenoord, Giacomo Cavalli, Susanna Chiocca, …

Nature, Vol.587(7834), pp.377-386

07/09/2020

DOI: https://doi.org/10.1038/s41586-020-2715-9

PMCID: PMC7656507

PMID: 32894860

Abstract

Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell resolution. This mission will be implemented through the development, integration and application of single-cell multi-omics and imaging, artificial intelligence and patient-derived experimental disease models during the progression from health to disease. The analysis of large molecular and clinical datasets will identify molecular mechanisms, create predictive computational models of disease progression, and reveal new drug targets and therapies. The timely detection and interception of disease embedded in an ethical and patient-centred vision will be achieved through interactions across academia, hospitals, patient associations, health data management systems and industry. The application of this strategy to key medical challenges in cancer, neurological and neuropsychiatric disorders, and infectious, chronic inflammatory and cardiovascular diseases at the single-cell level will usher in cell-based interceptive medicine in Europe over the next decade.

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Title: LifeTime and improving European healthcare through cell-based interceptive medicine
Creators - without role: Nikolaus Rajewsky - Max Delbrück Center
Geneviève Almouzni - Institut Curie
Stanislaw A Gorski - Max Delbrück Center
Stein Aerts - VIB-KU Leuven Center for Brain & Disease Research
Ido Amit - Weizmann Institute of Science
Michela G Bertero - Centre for Genomic Regulation
Christoph Bock - CeMM Research Center for Molecular Medicine
Annelien L Bredenoord - University Medical Center Utrecht
Giacomo Cavalli - Université de Montpellier, Institut de Génétique Humaine - IGH
Susanna Chiocca - European Institute of Oncology
Hans Clevers - Royal Netherlands Academy of Arts and Sciences
Bart de Strooper - VIB-KU Leuven Center for Brain & Disease Research
Angelika Eggert - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Jan Ellenberg - European Molecular Biology Laboratory
Xosé M Fernández - Institut Curie
Marek Figlerowicz - Poznań University of Technology
Susan M Gasser - University of Basel
Norbert Hubner - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Jørgen Kjems - Aarhus University
Jürgen A Knoblich - Austrian Academy of Sciences
Grietje Krabbe - Max Delbrück Center
Peter Lichter - Heidelberg University
Sten Linnarsson - Karolinska Institutet
Jean-Christophe Marine
John C Marioni - European Bioinformatics Institute
Marc A Marti-Renom
Mihai G Netea - Radboud University Medical Center
Dörthe Nickel - Université Paris Sciences et Lettres
Marcelo Nollmann - Université de Montpellier, Centre de Biologie Structurale - CBS
Halina R Novak
Helen Parkinson - European Bioinformatics Institute
Stefano Piccolo - IFOM
Inês Pinheiro - Université Paris Sciences et Lettres
Ana Pombo - Max Delbrück Center
Christian Popp - Max Delbrück Center
Wolf Reik - Wellcome Sanger Institute
Sergio Roman-Roman - Institut Curie
Philip Rosenstiel - University Hospital Schleswig-Holstein
Joachim L Schultze - University of Bonn
Oliver Stegle - European Bioinformatics Institute
Amos Tanay - Weizmann Institute of Science
Giuseppe Testa - European Institute of Oncology
Dimitris Thanos - Academy of Athens
Fabian J Theis - Helmholtz Zentrum München
Maria-Elena Torres-Padilla
Alfonso Valencia - Institució Catalana de Recerca i Estudis Avançats
Céline Vallot - Université Paris Sciences et Lettres
Alexander van Oudenaarden - Oncode Institute
Marie Vidal - Max Delbrück Center
Thierry Voet - Wellcome Sanger Institute
Lavinia Alberi - Swiss Integrative Center for Human Health
Stephanie Alexander - European Molecular Biology Laboratory
Theodore Alexandrov - European Molecular Biology Laboratory
Ernest Arenas - Karolinska Institutet
Claudia Bagni - University of Rome Tor Vergata
Robert Balderas - Becton Dickinson
Andrea Bandelli - Science Gallery International
Burkhard Becher - University of Zurich
Matthias Becker - German Center for Neurodegenerative Diseases
Niko Beerenwinkel - ETH Zurich
Monsef Benkirame - Institut de Génétique Moléculaire de Montpellier
Marc Beyer - German Center for Neurodegenerative Diseases
Wendy Bickmore - MRC Institute of Genetics and Molecular Medicine
Erik E a L Biessen - Maastricht University
Niklas Blomberg
Ingmar Blumcke - Universitätsklinikum Erlangen
Bernd Bodenmiller - University of Zurich
Barbara Borroni - University of Brescia
Dimitrios T Boumpas - Academy of Athens
Thomas Bourgeron - Université Paris Cité
Sarion Bowers - Wellcome Sanger Institute
Dries Braeken - IMEC
Catherine Brooksbank
Nils Brose - Max Planck Institute of Experimental Medicine
Hilgo Bruining - Amsterdam University Medical Centers
Jo Bury - Vlaams Instituut voor Biotechnologie
Nicolo Caporale - European Institute of Oncology
Giorgio Cattoretti - University of Milano-Bicocca
Nadia Chabane
Hervé Chneiweiss - Centre National de la Recherche Scientifique
Stuart A Cook - Imperial College London
Paolo Curatolo - University of Rome Tor Vergata
Marien I de Jonge - Radboud Institute for Molecular Life Sciences
Bart Deplancke
Bart de Strooper - VIB-KU Leuven Center for Brain & Disease Research
Peter de Witte - KU Leuven
Stefanie Dimmeler - Goethe University Frankfurt
Bogdan Draganski - Max Planck Institute for Human Cognitive and Brain Sciences
Anna Drews - German Center for Neurodegenerative Diseases
Costica Dumbrava - Directorate General for Communications Networks, Content and Technology
Stefan Engelhardt - Technical University of Munich
Thomas Gasser - Hertie Institute for Clinical Brain Research
Evangelos J Giamarellos-Bourboulis - National and Kapodistrian University of Athens
Caroline Graff - Karolinska University Hospital
Dominic Grün - University of Freiburg
Ivo Gut
Oskar Hansson - Lund University
David C Henshall - Royal College of Surgeons in Ireland
Anna Herland - KTH Royal Institute of Technology
Peter Heutink - German Center for Neurodegenerative Diseases
Stephane R B Heymans
Holger Heyn - Pompeu Fabra University
Meritxell Huch - Max Planck Institute of Molecular Cell Biology and Genetics
Inge Huitinga - Netherlands Institute for Neuroscience
Paulina Jackowiak - Institute of Bioorganic Chemistry, Polish Academy of Sciences
Karin R Jongsma - University Medical Center Utrecht
Laurent Journot - Institut de Génomique Fonctionnelle
Jan Philipp Junker - Max Delbrück Center
Shauna Katz - Université Paris Sciences et Lettres
Jeanne Kehren - Bayer
Stefan Kempa - Max Delbrück Center
Paulus Kirchhof - University of Birmingham
Christine Klein - University of Lübeck
Natalia Koralewska - Institute of Bioorganic Chemistry, Polish Academy of Sciences
Jan O Korbel - European Molecular Biology Laboratory
Malte Kühnemund
Angus I Lamond - University of Dundee
Elsa Lauwers - VIB-KU Leuven Center for Brain & Disease Research
Isabelle Le Ber - Sorbonne Université
Ville Leinonen - Oulu University Hospital
Alejandro Lopez Tobon - Human Technopole
Emma Lundberg - KTH Royal Institute of Technology
Astrid Lunkes - Helmholtz Zentrum München
Henrike Maatz - Max Delbrück Center
Matthias Mann - Novo Nordisk Foundation
Luca Marelli - KU Leuven
Vera Matser - European Bioinformatics Institute
Paul M Matthews - Imperial College London
Fatima Mechta-Grigoriou - Institut Curie
Radhika Menon - Mimetas (Netherlands)
Anne F Nielsen - Aarhus University
Massimiliano Pagani - University of Milan
R Jeroen Pasterkamp - University Medical Center Utrecht
Asla Pitkänen - University of Eastern Finland
Valentin Popescu - Max Delbrück Center
Cyril Pottier - VIB-UAntwerp Center for Molecular Neurology
Alain Puisieux - Université Paris Sciences et Lettres
Rosa Rademakers - VIB-UAntwerp Center for Molecular Neurology
Dory Reiling
Orly Reiner - Weizmann Institute of Science
Daniel Remondini
Craig Ritchie - University of Edinburgh
Jonathan D Rohrer - UK Dementia Research Institute
Antoine-Emmanuel Saliba - Helmholtz Institute for RNA-based Infection Research
Raquel Sanchez-Valle - Fundació Clínic per a la Recerca Biomèdica
Amedeo Santosuosso - University of Pavia
Arnold Sauter
Richard A Scheltema - Utrecht University
Philip Scheltens - Amsterdam University Medical Centers
Herbert B Schiller - German Center for Lung Research
Anja Schneider
Philip Seibler - University of Lübeck
Kelly Sheehan-Rooney - European Molecular Biology Laboratory
David Shields - Pfizer
Kristel Sleegers - VIB-UAntwerp Center for Molecular Neurology
August B Smit - Amsterdam Neuroscience
Kenneth G C Smith - University of Cambridge
Ilse Smolders - Vrije Universiteit Brussel
Matthis Synofzik - Hertie Institute for Clinical Brain Research
Wai Long Tam
Sarah Teichmann - Cavendish Hospital
Maria Thom - National Hospital for Neurology and Neurosurgery
Margherita Y Turco - University of Cambridge
Heleen M M van Beusekom - Erasmus MC
Rik Vandenberghe - KU Leuven
Silvie van den Hoecke
Ibo van de Poel - Delft University of Technology
Andre van der Ven - Radboud University Nijmegen
Julie van der Zee - VIB-UAntwerp Center for Molecular Neurology
Jan van Lunzen - Universität Hamburg
Geert van Minnebruggen - Vlaams Instituut voor Biotechnologie
Alexander van Oudenaarden - Oncode Institute
Wim van Paesschen - KU Leuven
John van Swieten - Erasmus MC
Remko van Vught - Mimetas (Netherlands)
Matthijs Verhage - Vrije Universiteit Amsterdam
Patrik Verstreken - VIB-KU Leuven Center for Brain & Disease Research
Carlo Emanuele Villa - European Institute of Oncology
Jörg Vogel - Helmholtz Institute for RNA-based Infection Research
Christof von Kalle - Berlin Institute of Health at Charité - Universitätsmedizin Berlin
Jörn Walter - Saarland University
Sarah Weckhuysen - VIB-UAntwerp Center for Molecular Neurology
Wilko Weichert - Technical University of Munich
Louisa Wood - Babraham Institute
Anette-Gabriele Ziegler
Frauke Zipp - Johannes Gutenberg University Mainz
Lavinia Alberi - Swiss Integrative Center for Human Health
Stephanie Alexander - European Molecular Biology Laboratory
Theodore Alexandrov - European Molecular Biology Laboratory
Ernest Arenas - Karolinska Institutet
Claudia Bagni - University of Rome Tor Vergata
Robert Balderas - Becton Dickinson
Andrea Bandelli - Science Gallery International
Burkhard Becher - University of Zurich
Matthias Becker - German Center for Neurodegenerative Diseases
Niko Beerenwinkel - ETH Zurich
Monsef Benkirane
Marc Beyer - German Center for Neurodegenerative Diseases
Wendy A. Bickmore - MRC Institute of Genetics and Molecular Medicine
Erik E. A. L. Biessen - Maastricht University
Niklas Blomberg
Ingmar Blumcke - Universitätsklinikum Erlangen
Bernd Bodenmiller - University of Zurich
Barbara Borroni - University of Brescia
Dimitrios T. Boumpas - Academy of Athens
Thomas Bourgeron - Université Paris Cité
Sarion Bowers - Wellcome Sanger Institute
Dries Braeken - IMEC
Catherine Brooksbank
Nils Brose - Max Planck Institute of Experimental Medicine
Hilgo Bruining - Amsterdam University Medical Centers
Jo Bury - Vlaams Instituut voor Biotechnologie
Nicolo Caporale - European Institute of Oncology
Giorgio Cattoretti - University of Milano-Bicocca
Nadia Chabane
Hervé Chneiweiss - Centre National de la Recherche Scientifique
Stuart A. Cook - Imperial College London
Paolo Curatolo - University of Rome Tor Vergata
Marien I. De Jonge
Bart Deplancke
Bart De Strooper
Peter De Witte
Stefanie Dimmeler - Goethe University Frankfurt
Bogdan Draganski - Max Planck Institute for Human Cognitive and Brain Sciences
Anna Drews - German Center for Neurodegenerative Diseases
Costica Dumbrava - Directorate General for Communications Networks, Content and Technology
Stefan Engelhardt - Technical University of Munich
Thomas Gasser - Hertie Institute for Clinical Brain Research
Evangelos J. Giamarellos-Bourboulis - National and Kapodistrian University of Athens
Caroline Graff - Karolinska University Hospital
Dominic Grün - University of Freiburg
Ivo G. Gut
Oskar Hansson - Lund University
David C. Henshall - Royal College of Surgeons in Ireland
Peter Heutink - German Center for Neurodegenerative Diseases
Stephane R. B. Heymans
Holger Heyn - Pompeu Fabra University
Meritxell Huch - Max Planck Institute of Molecular Cell Biology and Genetics
Inge Huitinga - Netherlands Institute for Neuroscience
Paulina Jackowiak - Institute of Bioorganic Chemistry, Polish Academy of Sciences
Karin R. Jongsma - University Medical Center Utrecht
Laurent Journot - Institut de Génomique Fonctionnelle
Jan Philipp Junker - Max Delbrück Center
Shauna Katz - Université Paris Sciences et Lettres
Jeanne Kehren - Bayer
Stefan Kempa - Max Delbrück Center
Paulus Kirchhof - University of Birmingham
Christine Klein - University of Lübeck
Natalia Koralewska - Institute of Bioorganic Chemistry, Polish Academy of Sciences
Jan O. Korbel - European Molecular Biology Laboratory
Malte Kühnemund
Angus I. Lamond - University of Dundee
Elsa Lauwers - VIB-KU Leuven Center for Brain & Disease Research
Isabelle Le Ber
Ville Leinonen - Oulu University Hospital
Alejandro López-Tobón
Emma Lundberg - KTH Royal Institute of Technology
Astrid Lunkes - Helmholtz Zentrum München
Henrike Maatz - Max Delbrück Center
Matthias Mann - Novo Nordisk Foundation
Luca Marelli - KU Leuven
Vera Matser - European Bioinformatics Institute
Paul M. Matthews - Imperial College London
Fatima Mechta-Grigoriou - Institut Curie
Radhika Menon - Mimetas (Netherlands)
Anne F. Nielsen - Aarhus University
Massimiliano Pagani - University of Milan
R. Jeroen Pasterkamp - University Medical Center Utrecht
Asla Pitkänen - University of Eastern Finland
Valentin Popescu - Max Delbrück Center
Cyril Pottier - VIB-UAntwerp Center for Molecular Neurology
Alain Puisieux - Université Paris Sciences et Lettres
Rosa Rademakers - VIB-UAntwerp Center for Molecular Neurology
Dory Reiling
Orly Reiner - Weizmann Institute of Science
Daniel Remondini
Craig Ritchie - University of Edinburgh
Jonathan D. Rohrer - UK Dementia Research Institute
Antoine-Emmanuel Saliba - Helmholtz Institute for RNA-based Infection Research
Raquel Sanchez-Valle - Fundació Clínic per a la Recerca Biomèdica
Amedeo Santosuosso - University of Pavia
Richard A. Scheltema - Utrecht University
Philip Scheltens - Amsterdam University Medical Centers
Herbert B. Schiller - German Center for Lung Research
Anja Schneider
Philip Seibler - University of Lübeck
Kelly Sheehan-Rooney - European Molecular Biology Laboratory
David J. Shields - Pfizer
Kristel Sleegers - VIB-UAntwerp Center for Molecular Neurology
August B. Smit - Amsterdam Neuroscience
Kenneth G. C. Smith - University of Cambridge
Ilse Smolders - Vrije Universiteit Brussel
Matthis Synofzik - Hertie Institute for Clinical Brain Research
Wai Long Tam
Sarah A. Teichmann - Cavendish Hospital
Maria Thom - National Hospital for Neurology and Neurosurgery
Margherita Y. Turco - University of Cambridge
Heleen M. M. Van Beusekom
Rik Vandenberghe - KU Leuven
Silvie van Den Hoecke
Ibo van De Poel
Andre van Der Ven
Julie van Der Zee
Jan Van Lunzen
Geert Van Minnebruggen
Alexander Van Oudenaarden
Wim Van Paesschen
John C. Van Swieten
Remko Van Vught
Matthijs Verhage - Vrije Universiteit Amsterdam
Patrik Verstreken - VIB-KU Leuven Center for Brain & Disease Research
Carlo Emanuele Villa - European Institute of Oncology
Jörg Vogel - Helmholtz Institute for RNA-based Infection Research
Christof Von Kalle
Jörn Walter - Saarland University
Sarah Weckhuysen - VIB-UAntwerp Center for Molecular Neurology
Wilko Weichert - Technical University of Munich
Louisa Wood - Babraham Institute
Anette-Gabriele Ziegler
Frauke Zipp - Johannes Gutenberg University Mainz
Publication Details: Nature, Vol.587(7834), pp.377-386
Identifiers: 9941891409311
Academic Unit: Institut de Génomique Fonctionnelle - IGF; Institut de Génétique Humaine - IGH; Centre de Biologie Structurale - CBS
Language: English
Resource Type: Journal article
Local Fields: hal-04023884