Letrozole and palbociclib versus chemotherapy as neoadjuvant therapy of high-risk luminal breast cancer

P Cottu; V d'Hondt; S Dureau; F Lerebours; I Desmoulins; Pe Heudel; Fp Duhoux; C Levy; Ma Mouret-Reynier; F Dalenc; Js Frenel; C Jouannaud; L Venat-Bouvet; S. Nguyen; Jm Ferrero; Jl Canon; Grenier J; C. Callens; D Gentien; J Lemonnier; A Vincent-Salomon; S Delaloge

doi:10.1093/annonc/mdy448

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Letrozole and palbociclib versus chemotherapy as neoadjuvant therapy of high-risk luminal breast cancer

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Letrozole and palbociclib versus chemotherapy as neoadjuvant therapy of high-risk luminal breast cancer

P Cottu, V d'Hondt, S Dureau, F Lerebours, I Desmoulins, Pe Heudel, Fp Duhoux, C Levy, Ma Mouret-Reynier, F Dalenc, …

Annals of Oncology

11/10/2018

DOI: https://doi.org/10.1093/annonc/mdy448

PMID: 30307466

Abstract

Palbociclib is a CDK4/6 inhibitor with demonstrated efficacy and safety in combination with endocrine therapy in advanced luminal breast cancer (LBC). We evaluated the respective efficacy and safety of chemotherapy and letrozole-palbociclib (LETPAL) combination as neoadjuvant treatment in patients with high-risk LBC.

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Title: Letrozole and palbociclib versus chemotherapy as neoadjuvant therapy of high-risk luminal breast cancer
Creators - without role: P Cottu - Institut Curie
V d'Hondt - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
S Dureau - Zimmer Biomet
F Lerebours - Institut Curie
I Desmoulins - Centre Georges François Leclerc
Pe Heudel
Fp Duhoux - Cliniques Universitaires Saint-Luc
C Levy - Centre François Baclesse
Ma Mouret-Reynier - Imagerie Moléculaire et Stratégies Théranostiques
F Dalenc - Institut Claudius Regaud
Js Frenel
C Jouannaud - Institut Jean Godinot
L Venat-Bouvet - Université de Limoges
S. Nguyen - Centre Hospitalier De Pau
Jm Ferrero - Centre Antoine Lacassagne
Jl Canon
Grenier J
C. Callens - Lille - Economie et Management
D Gentien - Institut Curie
J Lemonnier - UniCancer Group
A Vincent-Salomon - Institut Curie
S Delaloge - Institut Gustave Roussy
Publication Details: Annals of Oncology
Identifiers: 9947131809311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM
Language: English
Resource Type: Journal article
Local Fields: hal-01934672