Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems

Assala Al Samad; Audrey Bethry; Olga Janouskova; Jéremie Ciccione; Christiane Wenk; Jean-Luc Coll; Gilles Subra; Tomáš Etrych; Fawaz El Omar; Youssef Bakkour; Jean Coudane; Benjamin Nottelet

doi:10.1002/marc.201700502

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Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems

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Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems

Assala Al Samad, Audrey Bethry, Olga Janouskova, Jéremie Ciccione, Christiane Wenk, Jean-Luc Coll, Gilles Subra, Tomáš Etrych, Fawaz El Omar, Youssef Bakkour, …

Macromolecular Rapid Communications, Vol.39(3)

01/02/2018

DOI: https://doi.org/10.1002/marc.201700502

PMID: 29094415

Résumé

Stimuli-responsive polymers

Polyesters

Photochemistry

Functionalization of polymers

Drug delivery systems

Alkynes

Antineoplastic Agents

Photochemical Processes

Polyethylene Glycols

Sulfhydryl Compounds

Celle Line, Tumor

Cell Survival

Curcumin

Drug Delivery Systems

HEK293 Cells

Humans

Nanostructures

Advanced drug delivery systems (DDS) are easily designed following a photoiterative strategy. Multifunctional polymers are obtained by coupling building blocks of interest to an alkynated PCL platform via an efficient thiol-yne photoaddition. Fine tuning over the design is achieved as illustrated with targeting and enzyme-responsive DDS.

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Titre: Iterative Photoinduced Chain Functionalization as a Generic Platform for Advanced Polymeric Drug Delivery Systems
Créateurs - sans rôle: Assala Al Samad - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Audrey Bethry - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Olga Janouskova - Czech Academy of Sciences, Institute of Macromolecular Chemistry
Jéremie Ciccione - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Christiane Wenk - Institut pour l'avancée des biosciences
Jean-Luc Coll - Institut pour l'avancée des biosciences
Gilles Subra - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Tomáš Etrych - Czech Academy of Sciences, Institute of Macromolecular Chemistry
Fawaz El Omar - Lebanese University
Youssef Bakkour - Lebanese University
Jean Coudane - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Benjamin Nottelet - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Détails de publication: Macromolecular Rapid Communications, Vol.39(3)
Identifiants: 99153085109311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02387415