Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.

Jean-Marie Galano; Emilie Mas; Anne Barden; Trevor A Mori; Cinzia Signorini; Claudio de Felice; Aaron Barrett; Catherine Opere; Edith Pinot; Edzard Schwedhelm; Ralf Benndorf; Jérôme Roy; Jean-Yves Le Guennec; Camille Oger; Thierry Durand

doi:10.1016/j.prostaglandins.2013.04.003

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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.

Journal article

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Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.

Jean-Marie Galano, Emilie Mas, Anne Barden, Trevor A Mori, Cinzia Signorini, Claudio de Felice, Aaron Barrett, Catherine Opere, Edith Pinot, Edzard Schwedhelm, …

Prostaglandins and Other Lipid Mediators, Vol.107, pp.95-102

12/2013

DOI: https://doi.org/10.1016/j.prostaglandins.2013.04.003

PMID: 23644158

Abstract

Metabolites

Biomarkers

Isoprostanes

PUFAs

Bioactive lipids

Neuroprostanes

Isoprostanes (IsoPs) and neuroprostanes (NeuroPs) are formed in vivo by a free radical non-enzymatic mechanism involving peroxidation of arachidonic acid (AA, C20:4 n-6) and docosahexaenoic acid (DHA, C22:6 n-3) respectively. This review summarises our research in the total synthesis of these lipid metabolites, as well as their biological activities and their utility as biomarkers of oxidative stress in humans.

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Title: Isoprostanes and neuroprostanes: Total synthesis, biological activity and biomarkers of oxidative stress in humans.
Creators - without role: Jean-Marie Galano - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Emilie Mas - University of Western Australia
Anne Barden - University of Western Australia
Trevor A Mori - University of Western Australia
Cinzia Signorini - University of Siena
Claudio de Felice - Azienda Ospedaliera Universitaria Senese
Aaron Barrett - CHI Health Creighton University Medical Center - Bergan Mercy
Catherine Opere - Department of Pharmacy Sciences
Edith Pinot - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Edzard Schwedhelm - University Medical Center Hamburg-Eppendorf
Ralf Benndorf - University of Würzburg
Jérôme Roy - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Jean-Yves Le Guennec - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Camille Oger - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Thierry Durand - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Prostaglandins and Other Lipid Mediators, Vol.107, pp.95-102
Identifiers: 9946610609311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp; Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-00913158