Is survival influenced by metastatic site in synchronous metastatic pancreatic adenocarcinoma (PDAC)? A prospective real-world BACAP study

E. Alouani; C. Canivet; B. Bournet; L. Buscail; J. Selves; B. Napoleon; L. Palazzo; N. Flori; P. Guibert; A.-C. Brunac; C. Maulat; F. Muscari; F.-Z. Mokrane; S. Gourgou; L. Roca; R. Guimbaud; N. Fares; Barbara Bournet; Cindy Canivet; Louis Buscail; Nicolas Carrere; Fabrice Muscari; Bertrand Suc; Rosine Guimbaud; Corinne Couteau; Marion Deslandres; Pascale Rivera; Anne-Pascale Laurenty; Nadim Fares; Karl Barange; Janick Selves; Anne Gomez-Brouchet; Bertrand Napoleon; Bertrand Pujol; Fabien Fumex; Jerome Desrame; Christine Lefort; Vincent Lepilliez; Rodica Gincul; Pascal Artru; Lea Clavel; Anne-Isabelle Lemaistre; Laurent Palazzo; Jerome Cros; Sarah Tubiana; Nicolas Flori; Pierre Senesse; Pierre-Emmanuel Colombo; Emmanuelle SamailScalzi; Fabienne Portales; Sophie Gourgou; Claire Honfo Ga; Carine Plassot; Julien Fraisse; Fred eric Bibeau; Marc Ychou; Pierre Guibert; Christelle de la Fouchardiere; Matthieu Sarabi; Patrice Peyrat; Severine Tabone-Eglinger; Caroline Renard; Guillaume Piessen; Stephanie Truant; Alain Saudemont; Guillaume Millet; Florence Renaud; Emmanuelle Leteurtre; Patrick Gele; Eric Assenat; Jean-Michel Fabre; Francois-Regis Souche; Marie Dupuy; Anne-Marie Gorce-Dupuy; Jeanne Ramos; Jean-Francois Seitz; Jean Hardwigsen; Emmanuelle Norguet-Monnereau; Philippe Grandval; Muriel Duluc; Dominique Figarella-Branger; Veronique Vendrely; Clement Subtil; Eric Terrebonne; Jean-Frederic Blanc; Etienne Buscail; Jean-Philippe Merlio; Dominique Farges Bancel; Jean-Marc Gornet; Daniela Geromin; Geoffroy Vanbiervliet; Anne-Claire Frin; Delphine Ouvrier; Marie-Christine SaintPaul; Philippe Berthelemy; Chelbabi Fouad; Stephane Garcia; Nathalie Lesavre; Mohamed Gasmi; Marc Barthet; Vanessa Cottet; Cyrille Delpierre; BACAP Consortium

doi:10.1016/j.esmogo.2025.100144

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Is survival influenced by metastatic site in synchronous metastatic pancreatic adenocarcinoma (PDAC)? A prospective real-world BACAP study

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Is survival influenced by metastatic site in synchronous metastatic pancreatic adenocarcinoma (PDAC)? A prospective real-world BACAP study

E. Alouani, C. Canivet, B. Bournet, L. Buscail, J. Selves, B. Napoleon, L. Palazzo, N. Flori, P. Guibert, A.-C. Brunac, …

ESMO Gastrointestinal Oncology, Vol.8, p.100144

06/2025

DOI: https://doi.org/10.1016/j.esmogo.2025.100144

Résumé

lung-only metastases

metastatic site

pancreatic cancer

survival

Advanced pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis with a 5-year survival rate of 3%. While treated as an even population, previous retrospective studies suggested significantly different survival rates for patients with lung-only metastases when compared with other patients. This study aims to explore prospectively the difference in survival outcome based on initial site of metastases in synchronous metastatic PDAC. This is a prospective observational study including all adult patients with synchronous metastatic PDAC in BACAP (national Anatomo-Clinical Database on Pancreatic Adenocarcinoma). Data regarding patients’ demographics, tumor characteristics and survival outcomes were analyzed. Overall, 559 patients were included (52.8% male, mean age 69 years) of which 26 (4.7%), 65 (11.6%), 299 (53.5%) and 169 (30.2%) patients had lung-only, peritoneal-only, liver-only and multi-site metastases at diagnosis, respectively. The median overall survival (OS) was significantly different according to metastatic site (P < 0.001) with a median OS for lung-only, peritoneum-only, liver-only and multi-site of 12.6 months [95% confidence interval (CI) 9.7-16.9 months], 8.6 months (95% CI 5.4-11.5 months), 7.9 months (95% CI 6.5-8.9 months) and 4.5 months (95% CI 3.9-5.8 months), respectively. The median progression-free survival (PFS) was also significantly different according to metastatic site (P < 0.01) with a median PFS of 6.3 months (95% CI 2.7-9.1 months), 5.1 months (95% CI 3.7-6.2 months), 4.7 months (95% CI 3.3-5.7 months) and 3.2 months (95% CI 2.6-4.1 months), respectively. Patients with lung-only metastases represented 4.7% of synchronous metastatic PDAC patients and exhibited improved survival. These results suggest that a subset of patients with synchronous metastatic PDAC could benefit from more aggressive locoregional treatments. •OS and PFS varied significantly by metastatic site in synchronous metastatic PDAC.•Lung-only metastases represented 4.7% of synchronous metastatic PDAC.•Patients with lung-only PDAC metastases exhibited the most favorable prognosis.•Age >80 years old and neutrophils <7 G/l were associated with lung-only metastases.

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Titre: Is survival influenced by metastatic site in synchronous metastatic pancreatic adenocarcinoma (PDAC)? A prospective real-world BACAP study
Créateurs - sans rôle: E. Alouani - Digestive Medical Oncology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
C. Canivet - Department of Gastroenterology and Pancreatology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
B. Bournet - Department of Gastroenterology and Pancreatology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
L. Buscail - Department of Gastroenterology and Pancreatology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
J. Selves - Centre Hospitalier Universitaire de Toulouse
B. Napoleon - Department of Gastroenterology and Pancreatology, Hôpital Privé Jean Mermoz, Lyon, France
L. Palazzo - Service de gastro-entérologie, Clinique du Trocadéro, Paris, France
N. Flori - Clinical Nutrition and Gastroenterology Department, ICM—Institut du Cancer de Montpellier, Montpellier, France
P. Guibert - Centre Léon Bérard, Endoscopy Unit, Centre Léon Bérard, Lyon, France
A.-C. Brunac - Department of Pathology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France
C. Maulat - Department of Digestive Surgery, Centre Hospitalier Universitaire de Toulouse—Hopital Rangueil, Toulouse, France
F. Muscari - Department of Digestive Surgery, Centre Hospitalier Universitaire de Toulouse—Hopital Rangueil, Toulouse, France
F.-Z. Mokrane - Department of Radiology, Centre Hospitalier Universitaire de Toulouse—Hopital Rangueil, Toulouse, France
S. Gourgou - Biostatistics unit, ICM—Institut régional du Cancer de Montpellier, Val d’Aurelle, Montpellier, France
L. Roca - Biostatistics unit, ICM—Institut régional du Cancer de Montpellier, Val d’Aurelle, Montpellier, France
R. Guimbaud - Digestive Medical Oncology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
N. Fares - Digestive Medical Oncology, Centre Hospitalier Universitaire de Toulouse—Hôpital Rangueil, Toulouse, France
Barbara Bournet - The CHU and the University of Toulouse, Toulouse, France
Cindy Canivet - The CHU and the University of Toulouse, Toulouse, France
Louis Buscail - The CHU and the University of Toulouse, Toulouse, France
Nicolas Carrere - The CHU and the University of Toulouse, Toulouse, France
Fabrice Muscari - The CHU and the University of Toulouse, Toulouse, France
Bertrand Suc - The CHU and the University of Toulouse, Toulouse, France
Rosine Guimbaud - The CHU and the University of Toulouse, Toulouse, France
Corinne Couteau - The CHU and the University of Toulouse, Toulouse, France
Marion Deslandres - The CHU and the University of Toulouse, Toulouse, France
Pascale Rivera - The CHU and the University of Toulouse, Toulouse, France
Anne-Pascale Laurenty - The CHU and the University of Toulouse, Toulouse, France
Nadim Fares - The CHU and the University of Toulouse, Toulouse, France
Karl Barange - The CHU and the University of Toulouse, Toulouse, France
Janick Selves - The CHU and the University of Toulouse, Toulouse, France
Anne Gomez-Brouchet - The CHU and the University of Toulouse, Toulouse, France
Bertrand Napoleon - Jean Mermoz Hospital, Lyon, France
Bertrand Pujol - Jean Mermoz Hospital, Lyon, France
Fabien Fumex - Jean Mermoz Hospital, Lyon, France
Jerome Desrame - Jean Mermoz Hospital, Lyon, France
Christine Lefort - Jean Mermoz Hospital, Lyon, France
Vincent Lepilliez - Jean Mermoz Hospital, Lyon, France
Rodica Gincul - Jean Mermoz Hospital, Lyon, France
Pascal Artru - Jean Mermoz Hospital, Lyon, France
Lea Clavel - Jean Mermoz Hospital, Lyon, France
Anne-Isabelle Lemaistre - Jean Mermoz Hospital, Lyon, France
Laurent Palazzo - Trocadero Clinic, Paris, France
Jerome Cros - The Department of Pathology, Beaujon Hospital and Paris 7 University, Clichy, France
Sarah Tubiana - The Biobank, Bichat Hospital and Paris 7 University, Paris, France
Nicolas Flori - The Cancer Institute and the University of Montpellier, Montpellier, France
Pierre Senesse - The Cancer Institute and the University of Montpellier, Montpellier, France
Pierre-Emmanuel Colombo - The Cancer Institute and the University of Montpellier, Montpellier, France
Emmanuelle SamailScalzi - The Cancer Institute and the University of Montpellier, Montpellier, France
Fabienne Portales - The Cancer Institute and the University of Montpellier, Montpellier, France
Sophie Gourgou - The Cancer Institute and the University of Montpellier, Montpellier, France
Claire Honfo Ga - The Cancer Institute and the University of Montpellier, Montpellier, France
Carine Plassot - The Cancer Institute and the University of Montpellier, Montpellier, France
Julien Fraisse - The Cancer Institute and the University of Montpellier, Montpellier, France
Fred eric Bibeau - The Cancer Institute and the University of Montpellier, Montpellier, France
Marc Ychou - The Cancer Institute and the University of Montpellier, Montpellier, France
Pierre Guibert - The Leon Berard Cancer centre, Lyon, France
Christelle de la Fouchardiere - The Leon Berard Cancer centre, Lyon, France
Matthieu Sarabi - The Leon Berard Cancer centre, Lyon, France
Patrice Peyrat - The Leon Berard Cancer centre, Lyon, France
Severine Tabone-Eglinger - The Leon Berard Cancer centre, Lyon, France
Caroline Renard - The Leon Berard Cancer centre, Lyon, France
Guillaume Piessen - Université de Lille
Stephanie Truant - Université de Lille
Alain Saudemont - Université de Lille
Guillaume Millet - The Department of Digestive Surgery, the CHU and the University of Lille, Lille, France
Florence Renaud - The Department of Digestive Surgery, the CHU and the University of Lille, Lille, France
Emmanuelle Leteurtre - Université de Lille
Patrick Gele - Université de Lille
Eric Assenat - The CHU and the University of Montpellier, Montpellier, France
Jean-Michel Fabre - The CHU and the University of Montpellier, Montpellier, France
Francois-Regis Souche - The CHU and the University of Montpellier, Montpellier, France
Marie Dupuy - The CHU and the University of Montpellier, Montpellier, France
Anne-Marie Gorce-Dupuy - The CHU and the University of Montpellier, Montpellier, France
Jeanne Ramos - The CHU and the University of Montpellier, Montpellier, France
Jean-Francois Seitz - La Timone Hospital and the University of Marseille, Marseille, France
Jean Hardwigsen - La Timone Hospital and the University of Marseille, Marseille, France
Emmanuelle Norguet-Monnereau - La Timone Hospital and the University of Marseille, Marseille, France
Philippe Grandval - La Timone Hospital and the University of Marseille, Marseille, France
Muriel Duluc - La Timone Hospital and the University of Marseille, Marseille, France
Dominique Figarella-Branger - La Timone Hospital and the University of Marseille, Marseille, France
Veronique Vendrely - The CHU and the University of Bordeaux, Bordeaux, France
Clement Subtil - The CHU and the University of Bordeaux, Bordeaux, France
Eric Terrebonne - The CHU and the University of Bordeaux, Bordeaux, France
Jean-Frederic Blanc - The CHU and the University of Bordeaux, Bordeaux, France
Etienne Buscail - The CHU and the University of Bordeaux, Bordeaux, France
Jean-Philippe Merlio - The CHU and the University of Bordeaux, Bordeaux, France
Dominique Farges Bancel - Saint Louis Hospital and Paris 7 Diderot University, Paris, France
Jean-Marc Gornet - Saint Louis Hospital and Paris 7 Diderot University, Paris, France
Daniela Geromin - Saint Louis Hospital and Paris 7 Diderot University, Paris, France
Geoffroy Vanbiervliet - The CHU and the University of Nice, Nice, France
Anne-Claire Frin - The CHU and the University of Nice, Nice, France
Delphine Ouvrier - The CHU and the University of Nice, Nice, France
Marie-Christine SaintPaul - The CHU and the University of Nice, Nice, France
Philippe Berthelemy - Pau Hospital, Pau, France
Chelbabi Fouad - Pau Hospital, Pau, France
Stephane Garcia - The CHU Nord Hospital and the University of Marseille, Marseille, France
Nathalie Lesavre - The CHU Nord Hospital and the University of Marseille, Marseille, France
Mohamed Gasmi - The CHU Nord Hospital and the University of Marseille, Marseille, France
Marc Barthet - The CHU Nord Hospital and the University of Marseille, Marseille, France
Vanessa Cottet - Université de Bourgogne
Cyrille Delpierre - INSERM UMR1027 and the University of Toulouse, Toulouse France
BACAP Consortium
Détails de publication: ESMO Gastrointestinal Oncology, Vol.8, p.100144
Éditeur: Elsevier Ltd
Identifiants: 99139664709311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM; Institut de Génétique Moléculaire de Montpellier - IGMM
Langue: English
Type de ressource: Journal article