Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?

Denis Caillot; Stéphane Valot; Ingrid Lafon; Louise Basmaciyan; Marie Lorraine Chretien; Marc Sautour; Laurence Million; Caroline Legouge; Alexandre Payssot; Frédéric Dalle

doi:10.1093/ofid/ofw190

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Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?

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Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?

Denis Caillot, Stéphane Valot, Ingrid Lafon, Louise Basmaciyan, Marie Lorraine Chretien, Marc Sautour, Laurence Million, Caroline Legouge, Alexandre Payssot and Frédéric Dalle

Open Forum Infectious Diseases, Vol.3(4)

08/11/2016

DOI: https://doi.org/10.1093/ofid/ofw190

PMCID: PMC5225907

PMID: 28101518

Abstract

Early diagnosis

Leukemia

Pulmonary mucormycosis

Quantitative polymerase chain reaction

Reversed halo sign

In 23 leukemia patients with proven (n = 17) or possible (n = 6) pulmonary mucormycosis (PM), the presence of reversed halo sign on computed tomography was strongly associated with the positivity of quantitative polymerase chain reaction assays targeting Mucorales in the serum, confirming the value of these two tools for the diagnosis of PM in this setting.

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Title: Is It Time to Include CT “Reverse Halo Sign” and qPCR Targeting Mucorales in Serum to EORTC-MSG Criteria for the Diagnosis of Pulmonary Mucormycosis in Leukemia Patients ?
Creators - without role: Denis Caillot - Maison des Sciences de l’Homme de Dijon
Stéphane Valot - Centre Hospitalier Universitaire Dijon Bourgogne
Ingrid Lafon - Maison des Sciences de l’Homme de Dijon
Louise Basmaciyan - Institut Agro Dijon
Marie Lorraine Chretien - Maison des Sciences de l’Homme de Dijon
Marc Sautour - Centre Hospitalier Universitaire Dijon Bourgogne
Laurence Million - Laboratoire Chrono-Environnement
Caroline Legouge - Maison des Sciences de l’Homme de Dijon
Alexandre Payssot - Maison des Sciences de l’Homme de Dijon
Frédéric Dalle - Centre Hospitalier Universitaire Dijon Bourgogne
Publication Details: Open Forum Infectious Diseases, Vol.3(4)
Identifiers: 9938216909311
Academic Unit: Université de Montpellier
Language: English
Resource Type: Journal article
Local Fields: hal-01484030