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Iron-​Catalyzed Homocoupling of Aryl Halides and Derivatives in the Presence of Alkyllithiums
Journal article   Peer reviewed

Iron-​Catalyzed Homocoupling of Aryl Halides and Derivatives in the Presence of Alkyllithiums

Dounia Toummini, Fouad Ouazzani and Marc Taillefer
Organic Letters, Vol.15(18), pp.4690-4693
04/09/2013

Abstract

Direct synthesis of biaryl derivs. from aryl halides takes place under very mild temp. conditions by using a ligand-​free iron catalytic system. The procedure, which proceeds via an in situ quant. aryl halide exchange with alkyllithiums, allows for excellent control of the reactivity and is in line with the sustainable development. The method is also applicable to styryl and benzyl halides and to phenylacetylene.
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