International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Gabriel A. Brat; Griffin M. Weber; Nils Gehlenborg; Paul Avillach; Nathan P. Palmer; Luca Chiovato; James Cimino; Brett K. Beaulieu-Jones; Sehi L'Yi; Mark S. Keller; Douglas S. Bell; Robert W. Follett; Lav P. Patel; Anne Sophie Jannot; Lemuel R. Waitman; Gilbert Omenn; Alberto Malovini; Jason H. Moore; Valentina Tibollo; Shawn N Murphy; Riccardo Bellazzi; David A Hanauer; Arnaud Serret-Larmande; Alba Gutierrez-Sacristan; John J Holmes; Douglas Bell; Kenneth D. Mandl; Jeffrey G Klann; Douglas A Murad; Luigia Scudeller; Mauro Bucalo; Katie Kirchoff; Jean Craig; Jihad Obeid; Vianney Jouhet; Romain Griffier; Sébastien Cossin; Bertrand Moal; Antonio Bellasi; Hans U Prokosch; Detlef Kraska; Piotr Sliz; Amelia L.M. Tan; Kee Yuan Ngiam; Alberto Zambelli; Danielle L Mowery; Emily Schiver; Batsal Devkota; Robert Bradford; Mohamad Daniar; Christel Daniel; Vincent Benoit; Romain Bey; Nicolas Paris; Patricia Serre; Nina Orlova; Julien Dubiel; Martin Hilka; Stephane Breant; Judith Leblanc; Nicolas Griffon; Anita Burgun; Melodie Bernaux; Arnaud Sandrin; Elisa Salamanca; Sylvie Cormont; Thomas Ganslandt; Tobias Gradinger; Julien Champ; Martin Boeker; Patricia Martel; Loïc Estève; Alexandre Gramfort; Olivier Grisel; Damien Leprovost; Thomas Moreau; Gael Varoquaux; Jill-Jênn Vie; Demian Wassermann; Arthur Mensch; Charlotte Caucheteux; Christian Haverkamp; Guillaume Lemaître; Silvano Bosari; Andrew South; Tianxi Cai; Isaac Kohane

doi:10.1038/s41746-020-00308-0

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International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Journal article

Open access

International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium

Gabriel A. Brat, Griffin M. Weber, Nils Gehlenborg, Paul Avillach, Nathan P. Palmer, Luca Chiovato, James Cimino, Brett K. Beaulieu-Jones, Sehi L'Yi, Mark S. Keller, …

npj Digital Medicine, Vol.3(1)

12/2020

DOI: https://doi.org/10.1038/s41746-020-00308-0

PMID: 32864472

Abstract

Databases

Outcomes research

Viral infection

We leveraged the largely untapped resource of electronic health record data to address critical clinical and epidemiological questions about Coronavirus Disease 2019 (COVID-19). To do this, we formed an international consortium (4CE) of 96 hospitals across 5 countries (www.covidclinical.net). Contributors utilized the Informatics for Integrating Biology and the Bedside (i2b2) or Observational Medical Outcomes Partnership (OMOP) platforms to map to a common data model. The group focused on comorbidities and temporal changes in key laboratory test values. Harmonized data were analyzed locally and converted to a shared aggregate form for rapid analysis and visualization of regional differences and global commonalities. Data covered 27,584 COVID-19 cases with 187,802 laboratory tests. Case counts and laboratory trajectories were concordant with existing literature. Laboratory tests at the time of diagnosis showed hospital-level differences equivalent to country-level variation across the consortium partners. Despite the limitations of decentralized data generation, we established a framework to capture the trajectory of COVID-19 disease in patients and their response to interventions.

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Title: International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium
Creators - without role: Gabriel A. Brat - Harvard University
Griffin M. Weber - Harvard University
Nils Gehlenborg - Harvard University
Paul Avillach - Harvard University
Nathan P. Palmer - Harvard University
Luca Chiovato - University of Pavia
James Cimino - University of Alabama at Birmingham
Brett K. Beaulieu-Jones - Harvard University
Sehi L'Yi - Harvard Medical School
Mark S. Keller - Harvard University
Douglas S. Bell - David Geffen School of Medicine [Los Angeles]
Robert W. Follett - David Geffen School of Medicine [Los Angeles]
Lav P. Patel - University of Kansas
Anne Sophie Jannot - Hôpital Européen Georges-Pompidou
Lemuel R. Waitman - University of Kansas
Gilbert Omenn - University of Michigan–Ann Arbor
Alberto Malovini - Istituti Clinici Scientifici Maugeri
Jason H. Moore - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Valentina Tibollo - Istituti Clinici Scientifici Maugeri
Shawn N Murphy - Massachusetts General Hospital
Riccardo Bellazzi - Laboratory for BioMedical Informatics
David A Hanauer - University of Michigan–Ann Arbor
Arnaud Serret-Larmande - Hôpital Bichat-Claude-Bernard
Alba Gutierrez-Sacristan - Harvard University
John J Holmes - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Douglas Bell - David Geffen School of Medicine [Los Angeles]
Kenneth D. Mandl - Boston Children's Museum
Jeffrey G Klann - Massachusetts General Hospital
Douglas A Murad - David Geffen School of Medicine [Los Angeles]
Luigia Scudeller - IRCCS Ospedale San Raffaele
Mauro Bucalo - BIOMERIS [Pavia]
Katie Kirchoff - Medical University of South Carolina
Jean Craig - Medical University of South Carolina
Jihad Obeid - Medical University of South Carolina
Vianney Jouhet - Bordeaux Population Health
Romain Griffier - Centre Hospitalier Universitaire de Bordeaux
Sébastien Cossin - Bordeaux Population Health
Bertrand Moal - Laboratoire de biomécanique
Antonio Bellasi - Ospedale Papa Giovanni XXIII
Hans U Prokosch - Friedrich-Alexander-Universität Erlangen-Nürnberg
Detlef Kraska - Universitätsklinikum Erlangen
Piotr Sliz - Boston Children's Hospital
Amelia L.M. Tan - Harvard University
Kee Yuan Ngiam - National University Health System
Alberto Zambelli - Ospedale Papa Giovanni XXIII
Danielle L Mowery - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Emily Schiver - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
Batsal Devkota - Children's Hospital of Philadelphia
Robert Bradford - North Carolina Translational and Clinical Sciences [Chapel Hill]
Mohamad Daniar - Boston Children's Hospital
Christel Daniel - Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé
Vincent Benoit - Assistance Publique – Hôpitaux de Paris
Romain Bey - Assistance Publique – Hôpitaux de Paris
Nicolas Paris - Assistance Publique – Hôpitaux de Paris
Patricia Serre - Assistance Publique – Hôpitaux de Paris
Nina Orlova - Assistance Publique – Hôpitaux de Paris
Julien Dubiel - Assistance Publique – Hôpitaux de Paris
Martin Hilka - Assistance Publique – Hôpitaux de Paris
Stephane Breant - Assistance Publique – Hôpitaux de Paris
Judith Leblanc - Infection et inflammation
Nicolas Griffon - Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé
Anita Burgun - Centre de Recherche des Cordeliers
Melodie Bernaux - Assistance Publique – Hôpitaux de Paris
Arnaud Sandrin - Assistance Publique – Hôpitaux de Paris
Elisa Salamanca - Assistance Publique – Hôpitaux de Paris
Sylvie Cormont - Assistance Publique – Hôpitaux de Paris
Thomas Ganslandt - Heidelberg University
Tobias Gradinger - Heidelberg University
Julien Champ - Scientific Data Management
Martin Boeker - University of Freiburg
Patricia Martel - Assistance Publique – Hôpitaux de Paris
Loïc Estève - Modelling brain structure, function and variability based on high-field MRI data
Alexandre Gramfort - Modelling brain structure, function and variability based on high-field MRI data
Olivier Grisel - Modelling brain structure, function and variability based on high-field MRI data
Damien Leprovost - Clevy.io - Agents conversationnels à destination des grandes entreprises et du secteur public [Paris]
Thomas Moreau - Modelling brain structure, function and variability based on high-field MRI data
Gael Varoquaux - Mila - Quebec Artificial Intelligence Institute
Jill-Jênn Vie - Centre de Recherche en Informatique, Signal et Automatique de Lille
Demian Wassermann - Modelling brain structure, function and variability based on high-field MRI data
Arthur Mensch - Modelling brain structure, function and variability based on high-field MRI data
Charlotte Caucheteux - École Polytechnique
Christian Haverkamp - University of Freiburg
Guillaume Lemaître - Modelling brain structure, function and variability based on high-field MRI data
Silvano Bosari - University of Milan
Andrew South - Thomas Jefferson University
Tianxi Cai - Harvard University
Isaac Kohane - Harvard University
Publication Details: npj Digital Medicine, Vol.3(1)
Identifiers: 9940667909311
Academic Unit: Laboratoire d'Informatique de Robotique et de Microélectronique de Mtp - LIRMM
Language: English
Resource Type: Journal article
Local Fields: hal-02918344