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Interest of major serum protein removal for Surface-Enhanced Laser Desorption/Ionization - Time Of Flight (SELDI-TOF) proteomic blood profiling.
Journal article   Open access   Peer reviewed

Interest of major serum protein removal for Surface-Enhanced Laser Desorption/Ionization - Time Of Flight (SELDI-TOF) proteomic blood profiling.

S. Roche, Laurent Tiers, Monique Provansal, Marie-Thérèse Piva and Sylvain Lehmann
Proteome Science, Vol.4(1)
2006
DOI: https://doi.org/10.1186/1477-5956-4-20

Abstract

mass spectrometry SELDI-TOF serum proteomics clinical profiling Biomarker 2D-PAGE
Background: Surface-Enhanced Laser Desorption/Ionization – Time Of Flight (SELDI-TOF) has been proposed as new approach for blood biomarker discovery. However, results obtained so far have been often disappointing as this technique still has difficulties to detect low-abundant plasma and serum proteins.
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