Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats

Rita Malpique; Hugo Figueiredo; Yaiza Esteban; Sandra Rebuffat; Felicia Hanzu; Maria Vinaixa; Oscar Yanes; Xavier Correig; Sílvia Barceló-Batllori; Rosa Gasa; Susana Kalko; Ramon Gomis

doi:10.1007/s00125-014-3205-0

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Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats

Journal article

Peer reviewed

Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats

Rita Malpique, Hugo Figueiredo, Yaiza Esteban, Sandra Rebuffat, Felicia Hanzu, Maria Vinaixa, Oscar Yanes, Xavier Correig, Sílvia Barceló-Batllori, Rosa Gasa, …

Diabetologia, Vol.57(6), pp.1219-1231

06/2014

DOI: https://doi.org/10.1007/s00125-014-3205-0

PMID: 24633677

Abstract

Comprehensive characterisation of the interrelation between the peripancreatic adipose tissue and the pancreatic islets promises novel insights into the mechanisms that regulate beta cell adaptation to obesity. Here, we sought to determine the main pathways and key molecules mediating the crosstalk between these two tissues during adaptation to obesity by the way of an integrated inter-tissue, multi-platform analysis.

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Title: Integrative analysis reveals novel pathways mediating the interaction between adipose tissue and pancreatic islets in obesity in rats
Creators - without role: Rita Malpique - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Hugo Figueiredo - Pi
Yaiza Esteban - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Sandra Rebuffat - Université de Montpellier, Biocommunication en Cardio-Métabolique - BC2M
Felicia Hanzu - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Maria Vinaixa - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Oscar Yanes - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Xavier Correig - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Sílvia Barceló-Batllori - Institut d'Investigació Biomédica de Bellvitge
Rosa Gasa - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Susana Kalko - Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Ramon Gomis - Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
Publication Details: Diabetologia, Vol.57(6), pp.1219-1231
Identifiers: 9946683709311
Academic Unit: Biocommunication en Cardio-Métabolique - BC2M
Language: English
Resource Type: Journal article
Local Fields: hal-02103076