Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N'Djamena: Insights Into Chad's COVID-19 Epicenter

Mathiew Hota; Andrillene L D Wondeu; Mahamat F Abakar; Koutaya Dezoumbe; Fatima Abdelrazakh; Sabrina Atturo; Nathan Naïbeï; Giulia Cappelli; Franck Mennechet; Fissou H Yandai; Djamal H Abdallah; Zongo R F Edgard; Abdoulaye Boukar; Choroma A Moussa; Issa M Yaya; Mahamat I Hamad; Nontegyol Armand; Netalar Honorine; Kayanlengar Frederic; Adam A Moustapha; Yanda M Daniel; Adam M Alim; Mahamat Grene; Oumaima Djarma; Noubaramadji Y Suitombaye; Amine Akouya; Ouchemi Choua; Guy R T Dzomo; Djallaye Djimtoïbaye; Vittorio Colizzi; Mahamat A Moussa; Marta Giovanetti

doi:10.1002/jmv.70234

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Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N'Djamena: Insights Into Chad's COVID-19 Epicenter

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Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N'Djamena: Insights Into Chad's COVID-19 Epicenter

Mathiew Hota, Andrillene L D Wondeu, Mahamat F Abakar, Koutaya Dezoumbe, Fatima Abdelrazakh, Sabrina Atturo, Nathan Naïbeï, Giulia Cappelli, Franck Mennechet, Fissou H Yandai, …

Journal of medical virology, Vol.97(2), p.e70234

02/2025

DOI: https://doi.org/10.1002/jmv.70234

PMID: 39967351

Résumé

Adolescent

Adult

Aged

Antibodies, Viral - blood

Chad - epidemiology

COVID-19 - epidemiology

COVID-19 - immunology

COVID-19 - transmission

COVID-19 - virology

Female

Genetic Variation

Genome, Viral

Humans

Male

Middle Aged

SARS-CoV-2 - classification

SARS-CoV-2 - genetics

SARS-CoV-2 - immunology

SARS-CoV-2 - isolation & purification

Seroepidemiologic Studies

Whole Genome Sequencing

Young Adult

The COVID-19 epidemic has shown regional variations in transmission and outcomes. As a primary hotspot in Chad, N'Djamena is crucial for comprehensive epidemiological investigation. Our study employed two methodologies: seroprevalence data collection and whole-genome sequencing of SARS-CoV-2 strains. This dual approach assessed population exposure and virus genetic diversity. Seroprevalence data indicated broader exposure than confirmed cases suggested, and genome sequencing identified multiple strains, including globally recognized variants of concern. Integrating these data provided insights into transmission dynamics, potential herd immunity thresholds, and the impact of specific variants on disease progression. Our findings underscore the importance of integrated, multidisciplinary research in infectious disease epidemiology and inform targeted public health strategies, including social measures and vaccination, to combat infectious diseases in N'Djamena.

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Détails

Titre: Integrated Seroprevalence and Genome-Based Study of SARS-CoV-2 Viral Strains in N'Djamena: Insights Into Chad's COVID-19 Epicenter
Créateurs - sans rôle: Mathiew Hota - Department of Laboratories, Ministry of Public Health, N'Djamena, Chad
Andrillene L D Wondeu - Evangelical University of Cameroon, Bandjoun, Cameroon
Mahamat F Abakar - Institut de Recherche en Elevage pour le Développement (IRED), N'Djamena, Chad
Koutaya Dezoumbe - LAGET Major Tropical Epidemics Laboratory, Bon Samaritain University Hospital, N'Djamena, Chad
Fatima Abdelrazakh - Institut de Recherche en Elevage pour le Développement (IRED), N'Djamena, Chad
Sabrina Atturo - MAGIS Foundation, N'Djamena, Chad
Nathan Naïbeï - Community of Friends of Computing for Development "CAID-Tchad, N'Djamena, Chad
Giulia Cappelli - Institute for Biological Systems (ISB)-CNR, Monterotondo, Italy
Franck Mennechet - Inserm
Fissou H Yandai - Department of Laboratories, Ministry of Public Health, N'Djamena, Chad
Djamal H Abdallah - Department of Laboratories, Ministry of Public Health, N'Djamena, Chad
Zongo R F Edgard - OMS Tchad, Assistant Laboratoire COVID -19, N'Djamena, Chad
Abdoulaye Boukar - King Faycal Hospital N'Djamena, N'Djamena, Chad
Choroma A Moussa - Abeché University Hospital Laboratory, Abeché, Chad
Issa M Yaya - PMTCT/HIV Bol Health District, N'Djamena, Chad
Mahamat I Hamad - Biltine Provincial Hospital, Biltine, Chad
Nontegyol Armand - Doba Provincial Hospital, Doba, Chad
Netalar Honorine - Moundou Provincial Hospital, Moundou, Chad
Kayanlengar Frederic - Sarh Provincial Hospital, Sarh, Chad
Adam A Moustapha - Ati Provincial Hospital, Ati, Chad
Yanda M Daniel - Bongor Provincial Hospital, Bongor, Chad
Adam M Alim - Pala Provincial Hospital, Pala, Chad
Mahamat Grene - Mongo Provincial Hospital, Mongo, Chad
Oumaima Djarma - Department of Infectious Diseases/National University Hospital of Reference, Université Bon Samaritain, N'Djamena, Chad
Noubaramadji Y Suitombaye - LAGET Major Tropical Epidemics Laboratory, Bon Samaritain University Hospital, N'Djamena, Chad
Amine Akouya - LAGET Major Tropical Epidemics Laboratory, Bon Samaritain University Hospital, N'Djamena, Chad
Ouchemi Choua - National University Hospital of Reference, N'Djamena, Chad
Guy R T Dzomo - Le Bon Samaritain University Hospital Complex, N'Djamena, Chad
Djallaye Djimtoïbaye - LAGET Major Tropical Epidemics Laboratory, Bon Samaritain University Hospital, N'Djamena, Chad
Vittorio Colizzi - University of Rome "Tor Vergata", Rome, Italy
Mahamat A Moussa - National University Hospital of Reference, N'Djamena, Chad
Marta Giovanetti - Climate Amplified Diseases And Epidemics (CLIMADE), Belo Horizonte, Brazil
Détails de publication: Journal of medical virology, Vol.97(2), p.e70234
Note de subvention: The study was funded by the MAGIS foundation through the Italian Agency for Development Cooperation AID 04/Ciad/12022/202. Marta Giovanetti's funding is provided by PON "Ricerca e Innovazione" 2014-2020 and by the CRP-ICGEB RESEARCH GRANT 2020 Project CRP/BRA20-03, Contract CRP/20/03.
Identifiants: 99156958609311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article