Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort

Lise Cuzin; Pascal Pugliese; Christine Katlama; Firouzé Bani-Sadr; Tristan Ferry; David Rey; Jeremy Lourenco; Clotilde Allavena; Jacques Reynes; André Cabié; C Drobacheff-Thiébaut; A Foltzer; K. Bouiller; L Hustache-Mathieu; C. Chirouze; Q. Lepiller; F Bozon; O Babre; P. Muret; H. H. Laurichesse; O. Lesens; M Vidal; N Mrozek; C. Aumeran; O. Baud; V. V. Corbin; P Letertre; S. Casanova; C Jacomet; B. Hoen; I Lamaury; I Fabre; E Curlier; R Ouissa; K Schepers; C Herrmann-Storck; N Dournon; D Merrien; P. Perré; T Guimard; O Bollangier; S Leautez; M Morrier; F. Ader; F. Biron; A. Boibieux; L. Cotte; P. Miailhes; T. Perpoint; S. Roux; S Degroodt; C Brochier; F. Valour; C. Chidiac; C. Dhiver; M Saadia Mokhtari; A Ménard; H Tissot Dupont; C. Tomei; L. Meddeb; A. Belkhir; I. Ravaux; Sylvie Bregigeon; O. Zaegel-Faucher; V. Obry-Roguet; M Orticoni; M Soavi; I Luquet-Besson; E Ressiot; M Carta-Padovani; M. Ducassou; H Bertone; S Galie; A. Galinier; M Monclar; A Ritleng; A. Ivanova; C Blanco-Betancourt; C. Lions; I. Poizot-Martin; S. Abel; R. Césaire; G Dos Santos; L Fagour; M Illiaquer; F. Najioullah; D Nguyen; M Ouka; S Pierre-François; J. Pasquier; M. Pircher; B Rozé; N Atoui; V Le Moing; A. Makinson; N. Meftah; C Merle de Boever; B. Montes; a Montoya Ferrer; M. André; L. Boyer; M Bouillon; M Delestan; T. May; C Bernaud; E. Billaud; C Biron; B Bonnet; S Bouchez; D. Boutoille; C Brunet-Cartier; N. M.J. Hall; T. Jovelin; P Morineau; V. Reliquet; H Hue; S Sécher; M Cavellec; A. Soria; V. Ferre; E. André-Garnier; A. Rodallec; L Le Guen; M Lefebvre; O Grossi; P. Point; O. Aubry; L Khatchatourian; F. Raffi; S. Breaud; C Ceppi; J Courjon; E Cua; J. Cottalorda; P. Dellamonica; E Demonchy; a De Monte; J. Durant; C Etienne; S Ferrando; J Fuzibet; R Garraffo; A. Joulié; K Risso; V. Mondain; A. Naqvi; N. Oran; I Perbost; S. Pillet; B Prouvost-Keller; C Pradier; S Wehrlen-Pugliese; V Rio; E. Rosenthal; S Sausse; G Zouzou; L Hocqueloux; A Cheret; C Goujard; Y Quertainmont; E. Teicher; N. Lerolle; D. Vittecoq; O Deradji; F Fourreau; C. Pallier; A Barrail-Tran; R Landman; V Joly; C. Rioux; S Lariven; A Gervais; F. Lescure; S. Matheron; F Louni; C Godard; Z Julia; M Chansombat; D Rahli; C Mackoumbou-Nkouka; C. Charpentier; D. Descamps; G. Peytavin; Y. Yazdanpanah; P Consigny; G Cessot; P Bossi; J Goesch; J Gilquin; G Benabdelmoumen; F. Lanternier; C. Charlier; K. Amazzough; B Henry; B. Pilmis; C Rouzaud; M. Morgand; F Touam; C Louisin; C. Duvivier; O. Lortholary; R. Guery; F. Danion; P. Parize; N Etienne; M. Launay; C. Rouzioux; V Avettand Fenoel; M Valantin; P. Flandre; F. Caby; R Tubiana; R Agher; S Seang; L Schneider; R Palich; C Blanc; J. Berger; Y N’guyen; D. Lambert; D. Lebrun; I Kmiec; M. Hentzien; V Brodard; E. Botelho-Nevers; A. Gagneux-Brunon; A. Frésard; F. Lucht; P Fischer; M. Partisani; C. Cheneau; M Priester; M Batard; C Bernard-Henry; E de Mautort; M. Alvarez; N Biezunski; A. Debard; C. Delpierre; P Lansalot; L. Lelievre; Guillaume Martin-Blondel; D Metsu; M Piffaut; L. Porte; K Saune; Pierre Delobel; F Ajana; I Alcaraz; V Baclet; A. Boucher; P Choisy; T. Huleux; B. Lafon-Desmurs; H Melliez; A Meybeck; A. Pasquet; M Pradier; O Robineau; N Viget; M. Valette

doi:10.1093/jac/dky497

Article de revue

Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort

Lise Cuzin, Pascal Pugliese, Christine Katlama, Firouzé Bani-Sadr, Tristan Ferry, David Rey, Jeremy Lourenco, Clotilde Allavena, Jacques Reynes, André Cabié, …

Journal of Antimicrobial Chemotherapy, Vol.74(3), pp.754-760

01/03/2019

DOI: https://doi.org/10.1093/jac/dky497

PMID: 30534993

Résumé

Antiretroviral Therapy, Highly Active

CD4 Lymphocyte Count

HIV Integrase Inhibitors / therapeutic use

Heterocyclic Compounds, 3-Ring / adverse effects

Heterocyclic Compounds, 3-Ring / therapeutic use

Cohort Studies

Female

France / epidemiology

HIV Infections / complications*

HIV Infections / drug therapy

HIV Infections / epidemiology*

HIV Infections / virology

HIV Integrase Inhibitors / adverse effects*

Objectives: To analyse the frequency and causes of treatment discontinuation in patients who were treated with an integrase strand transfer inhibitor (INSTI), with a focus on neuropsychiatric adverse events (NPAEs).Methods: Patients in 18 HIV reference centres in France were prospectively included in the Dat'AIDS cohort. Data were collected from all patients starting an INSTI-containing regimen between 1 January 2006 and 31 December 2016. All causes of INSTI-containing regimen discontinuations were analysed, and patients' characteristics related to discontinuation due to NPAEs were sought.Results: INSTIs were prescribed to 21315 patients: 6274 received dolutegravir, 3421 received elvitegravir boosted by cobicistat, and 11620 received raltegravir. Discontinuation was observed in 12.5%, 20.2% and 50.9% of the dolutegravir-, elvitegravir- and raltegravir-treated patients, respectively (P < 0.001). Discontinuation for NPAEs occurred in 2.7%, 1.3% and 1.7% of the dolutegravir-, elvitegravir-, and raltegravir-treated patients, respectively (P < 0.001). In the multivariate analysis, discontinuation for NPAEs was related to dolutegravir versus elvitegravir (HR = 2.27; 95% CI 1.63-3.17; P < 0.0001) and versus raltegravir (HR = 2.46; 95% CI 2.00-3.40; P < 0.0001), but neither gender (HR for women = 1.19; 95% CI 0.97-1.46; P = 0.09) nor age (P = 0.12) was related. The association with abacavir was not retained in the final model.Conclusions: Although discontinuation for side effects was less frequent with dolutegravir than with boosted elvitegravir, discontinuation for NPAEs, although rare (2.7%), was more frequent with dolutegravir. No patient characteristic was found to be associated with these side effects in this very large population.

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Titre: Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort
Créateurs - sans rôle: Lise Cuzin - Centre Hospitalier Universitaire de Martinique
Pascal Pugliese - Centre Hospitalier Universitaire de Nice
Christine Katlama - Sorbonne Université
Firouzé Bani-Sadr - Centre Hospitalier Universitaire de Reims
Tristan Ferry - Inserm
David Rey - Université de Strasbourg
Jeremy Lourenco - Hôpital Necker-Enfants Malades
Clotilde Allavena - Nantes Université
Jacques Reynes - Université de Montpellier
André Cabié - Centre Hospitalier Universitaire de Martinique
C Drobacheff-Thiébaut - Inserm
A Foltzer
K. Bouiller - Laboratoire Chrono-Environnement
L Hustache-Mathieu - Inserm
C. Chirouze - Centre Hospitalier Universitaire de Besançon
Q. Lepiller - Centre Hospitalier Universitaire de Besançon
F Bozon - Inserm
O Babre
P. Muret
H. H. Laurichesse - Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand]
O. Lesens
M Vidal - Hôpital Necker-Enfants Malades
N Mrozek - Centre Hospitalier Universitaire de Martinique
C. Aumeran - Centre Hospitalier Universitaire de Martinique
O. Baud - CCLIN Sud-Est – Centre de Coordination de la Lutte contre les Infections Nosocomiales Sud-Est
V. V. Corbin - Service Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand]
P Letertre
S. Casanova - Université de Montpellier, Montpellier Recherche en Management - MRM
C Jacomet - Centre Hospitalier Universitaire de Martinique
B. Hoen - Inserm
I Lamaury
I Fabre
E Curlier - Centre Hospitalier Universitaire de Martinique
R Ouissa
K Schepers - Pitié-Salpêtrière Hospital
C Herrmann-Storck - Inserm
N Dournon - Inserm
D Merrien
P. Perré
T Guimard
O Bollangier
S Leautez
M Morrier - Assistance Publique – Hôpitaux de Paris
F. Ader - Hospices Civils de Lyon
F. Biron - Inserm
A. Boibieux - Hôpital de la Croix-Rousse
L. Cotte - HCL Technologies
P. Miailhes - Centre de Recherche en Cancérologie de Lyon
T. Perpoint - Hôpital de la Croix-Rousse
S. Roux
S Degroodt
C Brochier - Inserm
F. Valour - Hospices Civils de Lyon
C. Chidiac - Hôpital de la Croix-Rousse
C. Dhiver - Méditerranée Infection Foundation
M Saadia Mokhtari
A Ménard
H Tissot Dupont - Microbes Evolution Phylogénie et Infections
C. Tomei - Istituto Nazionale di Fisica Nucleare
L. Meddeb - Méditerranée Infection Foundation
A. Belkhir
I. Ravaux - Méditerranée Infection Foundation
Sylvie Bregigeon - Hôpital Sainte-Marguerite
O. Zaegel-Faucher - Hôpital Sainte-Marguerite
V. Obry-Roguet - Hôpital Sainte-Marguerite
M Orticoni - Assistance Publique – Hôpitaux de Paris
M Soavi
I Luquet-Besson
E Ressiot - Inserm
M Carta-Padovani - Hôpital Necker-Enfants Malades
M. Ducassou - Clinique Pasteur
H Bertone - Sorbonne Université
S Galie
A. Galinier - Neurobiologie, plasticité tissulaire et métabolisme énergétique
M Monclar - Hôpital Necker-Enfants Malades
A Ritleng
A. Ivanova
C Blanco-Betancourt - Inserm
C. Lions - DDSIS 76
I. Poizot-Martin - Hôpital Sainte-Marguerite
S. Abel - Hôpital Sainte-Marguerite
R. Césaire - Charmo University
G Dos Santos
L Fagour - Inserm
M Illiaquer - Assistance Publique – Hôpitaux de Paris
F. Najioullah - Virologie
D Nguyen
M Ouka - Hôpital Necker-Enfants Malades
S Pierre-François
J. Pasquier - Centre Hospitalier Universitaire de Montpellier
M. Pircher - Centre Hospitalier Universitaire de Martinique
B Rozé - Inserm
N Atoui - Inserm
V Le Moing
A. Makinson - Centre Hospitalier Régional Universitaire [Montpellier]
N. Meftah - Centre Hospitalier Universitaire de Martinique
C Merle de Boever
B. Montes
a Montoya Ferrer
M. André - Cliniques Universitaires UCL Mont-Godinne
L. Boyer - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
M Bouillon
M Delestan
T. May - Service des Maladies Infectieuses et Tropicales [CHRU Nancy]
C Bernaud
E. Billaud - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
C Biron
B Bonnet
S Bouchez
D. Boutoille - Service des maladies infectieuses et tropicales [CHU Nantes]
C Brunet-Cartier
N. M.J. Hall
T. Jovelin - Service de maladies infectieuses et tropicales [Nantes]
P Morineau
V. Reliquet - Service de maladies infectieuses et tropicales [Nantes]
H Hue
S Sécher
M Cavellec
A. Soria - Plant
V. Ferre - Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
E. André-Garnier - Université de Nantes
A. Rodallec - Virologie
L Le Guen
M Lefebvre
O Grossi
P. Point - Chercheur indépendant
O. Aubry
L Khatchatourian
F. Raffi - Service des maladies infectieuses et tropicales [CHU Nantes]
S. Breaud
C Ceppi
J Courjon
E Cua
J. Cottalorda - Service de chirurgie pédiatrique [Hôpital Lapeyronie-Arnaud de Villeneuve]
P. Dellamonica - Service des maladies infectieuses
E Demonchy
a De Monte
J. Durant
C Etienne
S Ferrando
J Fuzibet
R Garraffo
A. Joulié
K Risso
V. Mondain - Charmo University
A. Naqvi - Centre Hospitalier Universitaire de Nice
N. Oran - Hôpital l'Archet
I Perbost
S. Pillet
B Prouvost-Keller
C Pradier
S Wehrlen-Pugliese
V Rio
E. Rosenthal - Evelina London Children's Healthcare
S Sausse
G Zouzou
L Hocqueloux
A Cheret
C Goujard
Y Quertainmont
E. Teicher - Hôpital Bicêtre
N. Lerolle - Centre de recherche en Epidémiologie et Santé des Populations
D. Vittecoq - Service de Maladies Infectieuses et Tropicales [CHU Bicêtre]
O Deradji
F Fourreau
C. Pallier - Neuroimagerie cognitive
A Barrail-Tran
R Landman
V Joly
C. Rioux
S Lariven
A Gervais
F. Lescure
S. Matheron - Hôpital Bichat-Claude-Bernard
F Louni
C Godard
Z Julia
M Chansombat
D Rahli
C Mackoumbou-Nkouka
C. Charpentier - Registre EPIMAD
D. Descamps - Centre d'Etudes Lasers Intenses et Applications
G. Peytavin - Pharmacie de l'Hôpital Bichat
Y. Yazdanpanah - Lille - Economie et Management
P Consigny
G Cessot
P Bossi
J Goesch
J Gilquin
G Benabdelmoumen
F. Lanternier - Hôpital Necker-Enfants Malades
C. Charlier - Université Paris Descartes
K. Amazzough
B Henry
B. Pilmis
C Rouzaud
M. Morgand - Service des Maladies infectieuses et tropicales [CHU Necker]
F Touam
C Louisin
C. Duvivier
O. Lortholary
R. Guery - Université Paris Descartes
F. Danion - Service de rhumatologie [Strasbourg]
P. Parize
N Etienne
M. Launay
C. Rouzioux - Virologie
V Avettand Fenoel
M Valantin
P. Flandre - Institut Pierre Louis d'Epidémiologie et de Santé Publique
F. Caby - Charmo University
R Tubiana
R Agher
S Seang
L Schneider
R Palich
C Blanc
J. Berger
Y N’guyen
D. Lambert
D. Lebrun
I Kmiec
M. Hentzien - Hôpital universitaire Robert Debré [Reims]
V Brodard
E. Botelho-Nevers - Centre Hospitalier Universitaire de Saint-Étienne
A. Gagneux-Brunon - Centre Hospitalier Universitaire de Saint-Étienne
A. Frésard - Centre Hospitalier Universitaire de Saint-Étienne
F. Lucht - Centre Hospitalier Universitaire de Saint-Étienne
P Fischer
M. Partisani - Institut de Pharmacologie Moléculaire et Cellulaire
C. Cheneau - Centre de Recherche en Transplantation et Immunologie
M Priester
M Batard
C Bernard-Henry
E de Mautort
M. Alvarez
N Biezunski
A. Debard
C. Delpierre - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps
P Lansalot
L. Lelievre - Hôpital de la Croix-Rousse
Guillaume Martin-Blondel - Centre Hospitalier Universitaire de Toulouse
D Metsu
M Piffaut
L. Porte
K Saune
Pierre Delobel - Service Maladies infectieuses et tropicales [CHU Toulouse]
F Ajana
I Alcaraz
V Baclet
A. Boucher - Virologie
P Choisy
T. Huleux - Centre Hospitalier Tourcoing
B. Lafon-Desmurs - Charmo University
H Melliez
A Meybeck
A. Pasquet - Centre National de la Recherche Scientifique
M Pradier
O Robineau
N Viget
M. Valette - Virologie
Détails de publication: Journal of Antimicrobial Chemotherapy, Vol.74(3), pp.754-760
Identifiants: 99152893109311
Unité académique: Montpellier Recherche en Management - MRM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02559224