Insights into hominid evolution from the gorilla genome sequence

Aylwyn Scally; Julien Y. Dutheil; LaDeana W. Hillier; Gregory E. Jordan; Ian Goodhead; Javier Herrero; Asger Hobolth; Tuuli Lappalainen; Thomas Mailund; Tomas Marques-Bonet; Shane McCarthy; Stephen H. Montgomery; Petra C. Schwalie; Y. Amy Tang; Michelle C. Ward; Yali Xue; Bryndis Yngvadottir; Can Alkan; Lars N. Andersen; Qasim Ayub; Edward V. Ball; Kathryn Beal; Brenda J. Bradley; Yuan Chen; Chris M. Clee; Stephen Fitzgerald; Tina A. Graves; Yong Gu; Paul Heath; Andreas Heger; Emre Karakoc; Anja Kolb-Kokocinski; Gavin K. Laird; Gerton Lunter; Stephen Meader; Matthew Mort; James C. Mullikin; Kasper Munch; Timothy D. O'Connor; Andrew D. Phillips; Javier Prado-Martinez; Anthony S. Rogers; Saba Sajjadian; Dominic Schmidt; Katy Shaw; Jared T. Simpson; Peter D. Stenson; Daniel J. Turner; Linda Vigilant; Albert J. Vilella; Weldon Whitener; Baoli Zhu; David N. Cooper; Pieter de Jong; Emmanouil T. Dermitzakis; Evan E. Eichler; Paul Flicek; Nick Goldman; Nicholas I. Mundy; Zemin Ning; Duncan T. Odom; Chris P. Ponting; Michael A. Quail; Oliver A. Ryder; Stephen M. Searle; Wesley C. Warren; Richard K. Wilson; Mikkel H. Schierup; Jane Rogers; Chris Tyler-Smith; Richard Durbin

doi:10.1038/nature10842

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Insights into hominid evolution from the gorilla genome sequence

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Insights into hominid evolution from the gorilla genome sequence

Aylwyn Scally, Julien Y. Dutheil, LaDeana W. Hillier, Gregory E. Jordan, Ian Goodhead, Javier Herrero, Asger Hobolth, Tuuli Lappalainen, Thomas Mailund, Tomas Marques-Bonet, …

Nature (London), Vol.483(7388), pp.169-175

08/03/2012

DOI: https://doi.org/10.1038/nature10842

PMID: 22398555

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Gorillas are humans' closest living relatives after chimpanzees, and are of comparable importance for the study of human origins and evolution. Here we present the assembly and analysis of a genome sequence for the western lowland gorilla, and compare the whole genomes of all extant great ape genera. We propose a synthesis of genetic and fossil evidence consistent with placing the human-chimpanzee and human-chimpanzee-gorilla speciation events at approximately 6 and 10 million years ago. In 30% of the genome, gorilla is closer to human or chimpanzee than the latter are to each other; this is rarer around coding genes, indicating pervasive selection throughout great ape evolution, and has functional consequences in gene expression. A comparison of protein coding genes reveals approximately 500 genes showing accelerated evolution on each of the gorilla, human and chimpanzee lineages, and evidence for parallel acceleration, particularly of genes involved in hearing. We also compare the western and eastern gorilla species, estimating an average sequence divergence time 1.75 million years ago, but with evidence for more recent genetic exchange and a population bottleneck in the eastern species. The use of the genome sequence in these and future analyses will promote a deeper understanding of great ape biology and evolution.

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Titre: Insights into hominid evolution from the gorilla genome sequence
Créateurs - sans rôle: Aylwyn Scally - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Julien Y. Dutheil - Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
LaDeana W. Hillier - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Gregory E. Jordan - European Bioinformat Inst, Hinxton CB10 1SD, England
Ian Goodhead - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Javier Herrero - European Bioinformat Inst, Hinxton CB10 1SD, England
Asger Hobolth - Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
Tuuli Lappalainen - Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva 4, Switzerland
Thomas Mailund - Aarhus University
Tomas Marques-Bonet - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Shane McCarthy - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Stephen H. Montgomery - Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
Petra C. Schwalie - European Bioinformat Inst, Hinxton CB10 1SD, England
Y. Amy Tang - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Michelle C. Ward - Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Cambridge CB2 0XZ, England
Yali Xue - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Bryndis Yngvadottir - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Can Alkan - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Lars N. Andersen - Aarhus Univ, Bioinformat Res Ctr, DK-8000 Aarhus C, Denmark
Qasim Ayub - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Edward V. Ball - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
Kathryn Beal - European Bioinformat Inst, Hinxton CB10 1SD, England
Brenda J. Bradley - Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
Yuan Chen - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Chris M. Clee - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Stephen Fitzgerald - European Bioinformat Inst, Hinxton CB10 1SD, England
Tina A. Graves - Washington Univ, Sch Med, Genome Inst, St Louis, MO 63108 USA
Yong Gu - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Paul Heath - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Andreas Heger - Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford OX1 3QX, England
Emre Karakoc - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Anja Kolb-Kokocinski - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Gavin K. Laird - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Gerton Lunter - Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
Stephen Meader - Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford OX1 3QX, England
Matthew Mort - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
James C. Mullikin - NHGRI, Comparat Genom Unit, Genome Technol Branch, NIH, Bethesda, MD 20892 USA
Kasper Munch - Aarhus University
Timothy D. O'Connor - Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
Andrew D. Phillips - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
Javier Prado-Martinez - Inst Biol Evolut UPF CSIC, Barcelona 08003, Catalonia, Spain
Anthony S. Rogers - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Saba Sajjadian - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Dominic Schmidt - Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Cambridge CB2 0XZ, England
Katy Shaw - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
Jared T. Simpson - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Peter D. Stenson - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
Daniel J. Turner - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Linda Vigilant - Max Planck Inst Evolutionary Anthropol, Primatol Dept, D-04103 Leipzig, Germany
Albert J. Vilella - European Bioinformat Inst, Hinxton CB10 1SD, England
Weldon Whitener - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Baoli Zhu - Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
David N. Cooper - Cardiff Univ, Inst Med Genet, Cardiff CF14 4XN, S Glam, Wales
Pieter de Jong - Childrens Hosp Oakland, Res Inst, Oakland, CA 94609 USA
Emmanouil T. Dermitzakis - Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva 4, Switzerland
Evan E. Eichler - Univ Washington, Sch Med, Dept Genome Sci, Seattle, WA 98195 USA
Paul Flicek - European Bioinformat Inst, Hinxton CB10 1SD, England
Nick Goldman - European Bioinformat Inst, Hinxton CB10 1SD, England
Nicholas I. Mundy - Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England
Zemin Ning - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Duncan T. Odom - Wellcome Sanger Institute
Chris P. Ponting - Univ Oxford, Dept Physiol Anat & Genet, MRC Funct Genom Unit, Oxford OX1 3QX, England
Michael A. Quail - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Oliver A. Ryder - San Diego Zoos Inst Conservat Res, Escondido, CA 92027 USA
Stephen M. Searle - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Wesley C. Warren - Washington Univ, Sch Med, Genome Inst, St Louis, MO 63108 USA
Richard K. Wilson - Washington Univ, Sch Med, Genome Inst, St Louis, MO 63108 USA
Mikkel H. Schierup - Aarhus University
Jane Rogers - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Chris Tyler-Smith - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England
Richard Durbin - Wellcome Sanger Institute
Détails de publication: Nature (London), Vol.483(7388), pp.169-175
Éditeur: NATURE PORTFOLIO
Nombre de pages: 7
Note de subvention: Louis Jeantet Foundation Gates Cambridge Trust ICREA StG_20091118 / European Community Academy of Finlandand the Emil Aaltonen Foundation HG002385 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA WT062023; WT089066; WT077192; WT077009; WT077198; 075491/Z/04 / Wellcome Trust 09-062535 / Danish Council for Independent Research, Natural Sciences; Det Frie Forskningsrad (DFF) U54 HG003079 / NHGRI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiants: 99159346909311
Unité académique: Institut des Sciences de l'Evolution - Montpellier - ISEM
Langue: English
Type de ressource: Journal article