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Inside Back Cover: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. Int. Ed. 15/2020)
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Inside Back Cover: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. Int. Ed. 15/2020)

Christian Gentzsch, Kerstin Seier, Antonios Drakopoulos, Marie‐Lise Jobin, Yann Lanoiselée, Zsombor Koszegi, Damien Maurel, Rémy Sounier, Harald Hübner, Peter Gmeiner, …
Angewandte Chemie International Edition, Vol.59(15), pp.6289-6289
06/04/2020

Résumé

fluorescent probes G-protein coupled receptor homodimerization opioid ligands single-molecule microscopy
Highly selective fluorescent ligands derived from the opium poppy were developed by D. Calebiro, M. Decker et al. in their Research Article on page 5958 to investigate whether μ‐opioid receptors (μ‐ORs) can form dimers on the plasma membrane. These compounds exhibit long residence time and high affinity. Applying these chemical tools, single‐molecule microscopy allowed detection of a small fraction of short‐lived homodimers.

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