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Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells
Article de revue   Avec comité de lecture

Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells

Nathalie Dereuddre-Bosquet, Béatrice Roy, Kate Routledge, Pascal Clayette, Georges Foucault et Michel Lepoivre
Antiviral research, Vol.61(1), pp.67-70
2004
DOI: https://doi.org/10.1016/j.antiviral.2003.08.002
PMID: 14670596

Résumé

3TC CTP synthetase HIV PBMC
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.

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1 Consultations de la notice

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